Immature granulocytes predict severe acute pancreatitis independently of systemic inflammatory response syndrome

Lipiński, Michał; Rydzewska, Grażyna

doi:10.5114/pg.2017.68116

Cited by 21 publications

(30 citation statements)

References 21 publications

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“…[14][15][16] Recent studies have demonstrated that IG can be used as an effective inflammatory marker. [15,17,18,[25][26][27] Studies on the use of IG measurements in AA diagnosis and the discrimination between SA and CA are limited. [22,28,29] Mathews et al [28] found that an increased IG% was significant in the discrimination of acute and perforated appendicitis in the pediatric age group, but it did not bring any additional benefit to this discrimination when compared with an increased CRP level and shift to left.…”

Section: Discussionmentioning

confidence: 99%

A New And Early Marker In Diagnosis Of Acute Complicated Appendicitis: Immature Granulocyte

Ünal

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The aim of this study was to investigate the effectiveness of the immature granulocyte (IG) count (IGC) and percentage (IG%) in both diagnosing acute appendicitis (AA) and discriminating between simple appendicitis (SA) and complicated appendicitis (CA). METHODS:This study was carried out using the data of 438 adult patients who underwent an appendectomy. Demographic details, the preoperative white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), IGC and IG%, operation findings, and pathology results were assessed retrospectively. The patients were grouped as AA and normal appendix (NA) according to the pathology reports, and the AA cases were subdivided into SA and CA groups according to the intraoperative findings. RESULTS: WBC, NLR, IGC, and IG% were significant parameters in the diagnosis of AA. The area under the receiver operating characteristic curve (AUROC: 0.795), sensitivity (55.5%) and specificity (96.1%) values of IGC were higher than the other parameters. All of the parameters were also significant for a CA diagnosis; however, the value of IG% in a CA diagnosis was stronger than the other parameters (IG% AUROC: 0.979, sensitivity: 94.4%, specificity: 97.9%). CONCLUSION:The IG value is a fast, easily available, and reliable parameter in both diagnosing AA and discriminating between SA and CA.

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Section: Discussionmentioning

confidence: 99%

A New And Early Marker In Diagnosis Of Acute Complicated Appendicitis: Immature Granulocyte

Ünal

2018

Ulus Travma Acil Cerrahi Derg

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“…Patients’ age, gender, etiology of AP, laboratory parameters, Ranson score, revised Atlanta classification, duration of hospital stay and mortality rates were recorded. The revised Atlanta classification (mild: no organ failure and no local or systemic complications; moderately severe: transient organ failure (< 48 h) and/or local or systemic complications without persistent organ failure (> 48 h); severe: persistent organ failure (> 48 h): single organ failure or multiple organ failures) was used to diagnose the severity of AP [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…As the elderly population increasing, it is important to determine the prognosis of AP in the geriatric population. There are many scoring systems and laboratory parameters to determine the prognosis [ 3 – 6 ]. Ranson Criteria, Modified Glasgow Score, Acute Physiology and Chronic Health Evaluation II (APACHE II) are widely used scores.…”

Section: Introductionmentioning

confidence: 99%

Update on the effect of age on acute pancreatitis morbidity: a retrospective, single-center study

Kara¹,

Ölmez²,

Yalçın³

et al. 2018

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IntroductionAcute pancreatitis (AP) is one of the urgent diseases of gastroenterology. Due to the growth of the elderly population, the frequency of the disease in the elderly population is also increasing.AimTo evaluate the contributing factors of mortality in geriatric patients (age ≥ 65 years) and non-geriatric (age < 65 years) patients.Material and methodsWe retrospectively analyzed data of consecutive patients with AP, in the Adana Numune Education and Research Hospital between March 2013 and September 2015.ResultsOf the 602 patients studied, 405 were female and 197 were male and their mean age was 55.2 ±19.5 years. The most common etiological factors were biliary stone, hyperlipidemia and alcohol, respectively. Two hundred and four patients were in the geriatric group and 394 patients were in the non-geriatric group. 84.4% of patients had mild AP, and 15.6% of patients had moderate to severe AP according to the revised Atlanta classification. 91.7% of non-geriatric patients had mild AP while 70.7% of geriatric patients had mild AP (p < 0.001). 29.4% of geriatric patients had moderate-to-severe AP while 8.4% of non-geriatric patients had moderate-severe AP. Duration of hospital stay was 6.2 ±3 days and 5.3 ±2.3 days in geriatric and non-geriatric groups respectively (p < 0.001). Mortality was higher in the geriatric group than the non-geriatric group (9.6% vs. 0.5%, respectively) (p < 0.001).ConclusionsAcute pancreatitis in the geriatric population shows a more severe course than the non-geriatric population. Geriatric patients have longer duration of hospital stay and higher mortality than non-geriatric patients.

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“…Acute pancreatitis is a relatively common disease and severe acute pancreatitis (SAP) is associated with a high mortality rate, ranging from 15–40% ( 1 ). SAP starts as a local inflammation of pancreatic tissue and is characterized by the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction ( 2 , 3 ). Unfortunately, despite several years of experimental and clinical research, the precise pathophysiology of SAP, particularly in the clinical context remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone inhibits NF‑кBp65 and HMGB1 expression in the pancreas of rats with severe acute pancreatitis

et al. 2018

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Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extra-pancreatic organ dysfunction; however, the underlying mechanisms remain unclear. The present study was designed to evaluate the effect of dexamethasone (DXM) on pancreatic damage and to investigate the role of high-mobility group box-1 (HMGB1) and nuclear factor-κB (NF-κBp65) in the development of SAP in animal and cell models. For the in vivo experiment, 35 Sprague-Dawley rats were randomly assigned to three groups: The sham-operation control group, the SAP group and the DXM treatment group. Histological analysis revealed that, when DXM was infused into SAP rats, edema formation and structural alterations with necrosis were reduced, and the number of apoptotic cells was markedly reduced. In addition, compared with the SAP group, the expression level of HMGB1 was significantly decreased in the nucleus and the expression level of NF-κBp65 was significantly decreased in the cytoplasm from rats treated with DXM. In vitro, DXM was able to suppress the apoptosis and cell death induced by caerulein (CAE), and DXM could suppress the expression of NF-κBp65 and HMGB1 induced by CAE, as demonstrated by western blotting and immunofluorescence analysis. Therefore, these results provide an experimental basis for investigating the underlying therapeutic mechanisms of DXM treatment for SAP.

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Immature granulocytes predict severe acute pancreatitis independently of systemic inflammatory response syndrome

Cited by 21 publications

References 21 publications

A New And Early Marker In Diagnosis Of Acute Complicated Appendicitis: Immature Granulocyte

A New And Early Marker In Diagnosis Of Acute Complicated Appendicitis: Immature Granulocyte

Update on the effect of age on acute pancreatitis morbidity: a retrospective, single-center study

Dexamethasone inhibits NF‑кBp65 and HMGB1 expression in the pancreas of rats with severe acute pancreatitis

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