Clinical outcome and risk factors of neonatal sepsis among neonates in Felege Hiwot referral Hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a retrospective chart review

Abstract

BackgroundSepsis remains a major cause of morbidity and mortality among neonates. The risk factors and clinical outcomes of sepsis are poorly understood. Most cases of sepsis occurred mostly within the first week of newborns life related to perinatal risk factors. Late onset sepsis is related to hospital acquired infections which is seen after seven days of age. The purpose of this study was to assess clinical outcome and risk factors of neonatal sepsis in Felege Hiwot referral hospital Bahir Dar, North West Ethiopia.ResultsAmong the total 225 neonatal charts reviewed; 164 (72.9%) were age less than or equal to 7 days, and 144 (64%) were males. About 29 (12.9%) neonates were with irregular respiratory signs and 40 (17.8%) had meconium aspiration syndrome. Regarding the clinical outcome of neonatal sepsis: 189 (84%) were improved after treatment, 9 (4%) were died and 13 (5.8%) referred to other organizations for further treatment. Respiratory distress syndrome [AOR = 0.258 (0.072–0.930)] and meconium aspiration syndrome [AOR = 0.1989 (0.059–0.664)] were the determinant factors for poor outcome of neonatal sepsis.ConclusionThe clinical outcome of neonatal sepsis in Felege Hiwot referral hospital was not satisfactory. The significant risk factors for poor outcome of neonatal sepsis were respiratory distress syndrome and meconium aspiration syndrome. Recommendations to improve neonatal outcome are: performing essential newborn care for all newborns and arranging appropriate follow up until the end of neonatal period, increasing antenatal care and early detection and management of neonatal infections or problems.

A Five Years Retrospective Study on Etiology and Clinical Analysis of Meningitis in St. Paul’s Hospital Millennium Medical College Pediatric Ward from 2012-2016

“…The study conducted in Ethiopia indicated that around 15% of meningitis clients might end up with unwanted outs comes of which death is one of it. This finding is relatively lower than the current study result [26]. The difference might be because the study in Bahr Dar, Ethiopia was done for a short period of time that might be associated with difficulties in estimating the exact number within a short time.…”

Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

“…CSF sample collection after prior antimicrobial treatment could obviously contribute to culture negative results. The overall prevalence of bacterial meningitis of the current study was also lower than study conducted in Bahr Dar that reported a prevalence of 69.8% (33). This difference could be due to difference diagnostic method.…”

Prevalence and factors associated with neonatal sepsis in a tertiary hospital, North West Nigeria

“… 46 However, contrasting findings were observed in earlier studies conducted in different parts of the world. 9 44 47 48 49 Early rupture of membrane and prolonged labor increases the chance of ascending microorganisms from the birth canal into the amniotic sac and fetal compromise as well as asphyxia which frequently leads to sepsis in the neonatal period. 50 This finding could serve as justification for prophylactic antibiotic therapy for neonates born to mothers with a history of PROM during pregnancy.…”