Serum IL-10, IL-17 and IL-23 levels as “bioumoral bridges” between dyslipidemia and atopy

Manti, Sara; Leonardi, ﻿Salvatore; Panasiti, Ilenia; Arrigo, Teresa; Salpietro, Carmelo; Cuppari, Caterina

doi:10.1016/j.cyto.2017.07.002

Cited by 30 publications

(26 citation statements)

References 25 publications

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“…IL-10 gene is a key gene for regulating immune response during infections (Couper, Blount, & Riley, 2008). It is also a gene that associated with other cytokines, such as TNF-∂ (Qin, Wang, Liang, et al, 2013), IL-17, IL-23 (Manti et al, 2017), and IL-4 (Makita, Hizukuri, Yamashiro, Murakawa, & Hayashi, 2015). Thus, by editing IL-10, the whole IL-10 related pathway can be influenced, and it might cause significant phenotype changes.…”

Section: Inspired By How the Microbiota And Vitamins C And B 3 Can Inmentioning

confidence: 99%

Vitamin C and B₃ as new biomaterials to alter intestinal stem cells

Lohman

Bratlie

et al. 2019

J Biomedical Materials Res

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Vitamin C (ascorbic acid) and vitamin B3 (niacin) have been extensively studied since the 20th century. In the area of stem cell biology, vitamin C has shown its direct impact toward homeostasis and epigenetic changes (D'Aniello et al., Stem Cells International, 2017, 1–16). Vitamin B3 aids in maintaining healthy intestinal homeostasis and reducing gut inflammation by participating in the rapamycin signaling pathway (Kumar et al., The American Journal of Physiology‐Gastrointestinal and Liver Physiology, 2013). In this study, vitamin C and vitamin B3 (600 and 1,200 μg/mL) have been explored as potential new biomaterials to study their effects on four types of intestinal stem cells which are isolated from mice bearing different microbiota. We observed that C3H ASF and 129 ASF IL‐10 are more sensitive towardB7 600 μg/mL vitamin B3 and 1,200 μg/mL vitamin C. The lowest growth rate and viability for all types of organoids was with 1,200 μg/mL vitamin C. From quantitative polymerase chain reaction analysis (qPCR analysis), MUC2 was upregulated for 129 ASF and C3H Conv when exposed to 600 μg/mL and 1,200 μg/mL vitamin C. It suggests that large amounts of glycoprotein may be produced after adding high concentrations of vitamin C. Since inflammatory bowel disease has low level of MUC2, this finding may be helpful in restoring mucosal health by upregulating the MUC2 gene while altering patient's microbiota (Sibila et al., Annals of the American Thoracic Society, 2016). These results are expected to have a positive translational impact because this bottom‐up strategy would be instrumental in developing Vitamin C and B3 based orally available therapeutic strategies and formula for advancing the fields of gastrointestinal regenerative medicine.

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Section: Inspired By How the Microbiota And Vitamins C And B 3 Can Inmentioning

confidence: 99%

Vitamin C and B₃ as new biomaterials to alter intestinal stem cells

Lohman

Bratlie

et al. 2019

J Biomedical Materials Res

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“…26 In particular, elevated TG and LDL-C lead to increased pro-inflammatory signaling and increased expression of TNF-α and interleukin (IL)-6. 26,27 In contrast, HDL-C has an anti-inflammatory effect, in that it modulates Tcell activation. 26,27 This supports the interpretation that the presence of a chronic inflammatory state (as indicated by dyslipidemia) is responsible for chronic skin inflammation, and provides a possible mechanism for the relationship between atopic dermatitis and hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

Association of serum lipid parameters with the severity and onset of atopic dermatitis in children

Kim

Lee

Yon

et al. 2020

Preprint

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Background The association between dyslipidemia and atopic dermatitis in children is unclear. This study investigated the association between dyslipidemia and atopic dermatitis in children by analysis of disease onset, risk factors, and disease severity. Methods Subset I examined 7 year-old children in elementary school (n = 248) and Subset II was a retrospective long-term follow-up hospital based-study (n = 52,725) conducted from 1986 to 2016 that used propensity score matching. In the Subset I Study, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) were determined, and the severity of atopic dermatitis was determined using SCORing Atopic Dermatitis (SCORAD). In the Subset II Study, the time of atopic dermatitis onset was determined for asymptomatic subjects whose TC levels were below or above 170 mg/dL. Results Our Subset I Study indicated that children with atopic dermatitis (n = 69, 27.8%) had significantly higher levels of TC and TG, and that disease severity had significant associations with high levels of TC and TG, and a low level of HDL-C. Our Subset II Study (1,722 with high TC and 6,735 with normal TC after propensity score matching) indicated the high TC group had a greater hazard ratio (HR) for the onset of atopic dermatitis (consensus-based HR: 2.47; 95% CI: 1.23, 5.06, P = 0.012) during 5 years. Conclusion An abnormal blood lipid profile in children is associated with the presence and severity of atopic dermatitis. The risk of atopic dermatitis onset was significantly greater with high levels of TC. Association of serum lipid parameters with the severity and onset of atopic dermatitis in children Conclusion An abnormal blood lipid profile in children is associated with the presence and severity of atopic dermatitis. The risk of atopic dermatitis onset was significantly greater with high levels of TC.

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“…Conversely, Teague et al [81] reported that children with pauci-granulocytic asthma (with no evidence of increased numbers of eosinophils or neutrophils in sputum or blood and in whom antiinflammatory therapies are ineffective at controlling symptoms) experienced a lower post-bronchodilator airflow limitation, less blood eosinophilia, fewer doses of prednisone, and fewer infectious species than children with mixed granulocytic BAL [81]. Moreover, a strong relationship between sputum and blood neutrophils, as well as with asthma severity, was also reported, suggesting neutrophilic lung inflammation as a risk factor for poorly controlled asthma [82,83].…”

Section: Biomarkers Of the Nontype 2 Asthma Endotype Neutrophilsmentioning

confidence: 99%

Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice

Licari

Manti

Leonardi

2020

Breathe

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Severe asthma in children is a highly heterogeneous disorder, encompassing different clinical characteristics (phenotypes) and immunopathological pathways (endotypes). Research is focusing on the identification of noninvasive biomarkers able to predict treatment response and assist in designing personalised therapies for severe asthma. Blood and sputum eosinophils, serum IgE and exhaled nitric oxide fraction mostly reflect type 2 airway inflammation in children. However, in the absence of available point-of-care biomarkers, the diagnosis of non-type 2 asthma is still reached by exclusion. In this review, we present the most recent evidence on biomarkers for severe asthma and discuss their implementation in clinical practice. We address the methods for guiding treatment decisions and patient identification, focusing on the paediatric age group.Key pointsSevere asthma in children is a highly heterogeneous disorder, encompassing different clinical characteristics (phenotypes) and immunopathological pathways (endotypes).Research is focusing on the identification of noninvasive biomarkers able to predict treatment response and assist in designing personalised therapies for severe asthma.Blood and sputum eosinophils, serum IgE and exhaled nitric oxide fraction mostly reflect type 2 airway inflammation in children. However, knowledge regarding non-type 2 inflammation and related biomarkers is still lacking.Educational aimsTo summarise the most recent evidence on biomarkers for severe asthma in children.To discuss their implementation in clinical practice through guiding patient identification and treatment decisions.

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Serum IL-10, IL-17 and IL-23 levels as “bioumoral bridges” between dyslipidemia and atopy

Cited by 30 publications

References 25 publications

Vitamin C and B₃ as new biomaterials to alter intestinal stem cells

Vitamin C and B₃ as new biomaterials to alter intestinal stem cells

Association of serum lipid parameters with the severity and onset of atopic dermatitis in children

Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice

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Serum IL-10, IL-17 and IL-23 levels as “bioumoral bridges” between dyslipidemia and atopy

Cited by 30 publications

References 25 publications

Vitamin C and B3 as new biomaterials to alter intestinal stem cells

Vitamin C and B3 as new biomaterials to alter intestinal stem cells

Association of serum lipid parameters with the severity and onset of atopic dermatitis in children

Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice

Contact Info

Product

Resources

About

Vitamin C and B₃ as new biomaterials to alter intestinal stem cells

Vitamin C and B₃ as new biomaterials to alter intestinal stem cells