Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta‐analysis of randomised placebo‐control human clinical trials

AbuMweis, Suhad S.; Jew, Stephanie; Tayyem, Reema; Agraib, Lana M.

doi:10.1111/jhn.12493

Cited by 97 publications

(68 citation statements)

References 179 publications

(19 reference statements)

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“…There is good evidence that VLC n-3 PUFAs can favourably modify several biological processes which play a role in promoting atherosclerosis [11], including inflammation [12,13]. These beneficial modifications, which would result in preventing the initiation and slowing the progress of atherosclerosis, include a reduction in endothelium-leukocyte interactions.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions

Baker

Yusof

Yaqoob

et al. 2018

Molecular Aspects of Medicine

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Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel wall. Here, monocytes differentiate into macrophages and may become foam cells, contributing to the initiation and progression of an atherosclerotic plaque. The ability of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) to influence the expression of adhesion molecules by ECs and to modulate leukocyte-endothelial adhesion has been studied in cell culture using various types of ECs, in animal feeding studies and in human trials; the latter have tended to evaluate soluble forms of adhesion molecules that circulate in the bloodstream. These studies indicate that n-3 PUFAs (both eicosapentaenoic acid and docosahexaenoic acid) can decrease the expression of key adhesion molecules, such as vascular cell adhesion molecule 1, by ECs and that this results in decreased adhesive interactions between leukocytes and ECs. These findings suggest that n-3 PUFAs may lower leukocyte infiltration into the vascular wall, which could contribute to reduced atherosclerosis and lowered risk of cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions

Baker

Yusof

Yaqoob

et al. 2018

Molecular Aspects of Medicine

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“…Hypotensive effect has also been documented with regard to DHA and EPA. Intake of n-3 PUFAs at a dose of over 3 g per day resulted in systolic BP (SBP) decrease of 5.5 mmHg on average and diastolic BP (DBP) drop of 3.5 mmHg on av-erage, and the hypotensive effect of DHA was stronger than one achieved with EPA [11]. The antihypertensive effect of n-3 fatty acids would not be unexpected because one of the concepts possibly explaining pathogenesis of hypertension is the membrane hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Linseed oil increases HDL3 cholesterol and decreases blood pressure in patients diagnosed with mild hypercholesterolaemia

et al. 2018

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A b s t r a c tBackground: Linseed oil has cardio-protective effects. However, its antihypertensive action has not yet been well characterised. Aim:The primary purpose of the study was to evaluate the effect of short-term dietary supplementation with linseed oil on blood pressure (BP) and lipid metabolism in patients with mild hypercholesterolaemia. The secondary aim was to assess the effect of linseed oil on nitric oxide pathway and selected serum trace metals.Methods: 150 volunteers: 43 men (49.9 ± 11.5 years) and 107 women (53.2 ± 10.3 years), diagnosed with mild hypercholesterolaemia, were assessed prospectively for BP and lipid levels, before and after lipid-lowering diet plus linseed oil supplementation at a dose of 15 mL daily for four weeks (study groups) or four-weekly lipid-lowering diet (control group). Multivariate logistic regression analysis was used to determine the effect of linseed oil on BP after adjustment for age, sex, height, body weight, body mass index, smoking status, and alcohol consumption.Results: Supplementation with linseed oil significantly decreased low-density lipoprotein (LDL)-and non-high-density lipoprotein (HDL) cholesterol, and increased HDL-and HDL 3 -cholesterol levels. Additionally, linseed oil decreased diastolic BP in men (95% confidence interval [CI]: -6.0 to -1.1, p < 0.006), whereas in women linseed oil reduced (p < 0.001) systolic BP (-3.6 mmHg; 95% CI: -5.8 to -1.5) as well as diastolic BP (-4 mmHg; 95% CI: -5.8 to -2.1). Women with higher BP displayed an increase in serum L-arginine level (p < 0.01). In the logistic regression model oil consumption was associated with a decrease in mean BP (adjusted odds ratio 3.85; 95% CI 1.32-11.33). Conclusions:Our findings confirm the benefit of short-term linseed oil use in mild hypercholesterolaemia, particularly in patients with increased blood pressure.

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“…Eine Erhöhung des Omega-3-Index senkt den Blutdruck und die Herzfrequenz, Triglyzeride und zahlreiche Biomarker der Inflammation, erhöht die Herzfrequenzvariabilität und verbessert die Endothelfunktion; das heißt, mehrere Surrogatparameter bzw. Risikofaktoren für kardiovaskuläre Erkrankungen werden verbessert [2,36]. Auch Intermediärparameter, wie Regression und Progression koronarer Läsionen, oder Parameter der linksventrikulären Struktur und Funktion werden so positiv beeinflusst [19,36].…”

Section: Kardiovaskuläre Präventionunclassified

Verwirrung um die Wirkung von Omega-3-Fettsäuren

Schacky

2019

Internist

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Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta‐analysis of randomised placebo‐control human clinical trials

Cited by 97 publications

References 179 publications

Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions

Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions

Linseed oil increases HDL3 cholesterol and decreases blood pressure in patients diagnosed with mild hypercholesterolaemia

Verwirrung um die Wirkung von Omega-3-Fettsäuren

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