Controlled release of Doxycycline from gum acacia/poly(sodium acrylate) microparticles for oral drug delivery

Bajpai, S. K.; Jadaun, Mamta; Bajpai, M.; Jyotishi, Pooja; Shah, Farhan Ferooz; Tiwari, Seema

doi:10.1016/j.ijbiomac.2017.06.108

Cited by 25 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52−54 In the PNIPAM-SA (PNS) hydrogel spectrum, the absorption peak at 1720 cm −1 was ascribed to C�O stretching of SA. 55,56 In the PNIPAM-SA/ALG (PNSA) hydrogel spectrum, the broad absorption peak at 3400 cm −1 was assigned to O−H stretching from the hydroxy group of ALG, and the absorption peak at 1040 cm −1 was assigned to C−O antisymmetric vibration from the C−O−C group of ALG. 57 Notably, the introduction of ALG resulted in the formation of hydrogen bonds between PNIPAM and ALG; thus, the C�O stretching peak from the amido group of PNIPAM shifted from 1650 to 1637 cm −1 in the PNSA hydrogel spectrum.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Multistimuli-Responsive PNIPAM-Based Double Cross-Linked Conductive Hydrogel with Self-Recovery Ability for Ionic Skin and Smart Sensor

et al. 2022

View full text Add to dashboard Cite

Multistimuli-responsive conductive hydrogels have been appealing candidates for multifunctional ionic skin. However, the fabrication of the multistimuli-responsive conductive hydrogels with satisfactory mechanical property to meet the practical applications is still a great challenge. In this study, a novel poly(N-isopropylacrylamide-co-sodium acrylate)/alginate/hectorite clay Laponite XLS (PNIPAM-SA/ALG/XLS) double cross-linked hydrogel with excellent mechanical property, self-recovery ability, temperature/pH-responsive ability, and strain/temperature-sensitive conductivity was fabricated. The PNSAX hydrogel possessed a moderate tensile strength of 290 kPa at a large elongation rate of 1120% and an excellent compression strength of 2.72 MPa at 90%. The hydrogel also possessed excellent mechanical repeatability and self-recovery ability. Thus, the hydrogel could withstand repetitive deformations for long time periods. Additionally, the hydrogel could change its transparency and volume once at a temperature of 44 °C and change its volume at different pHs. Thus, the visual temperature/pH-responsive ability allowed the hydrogel to qualitatively harvest environmental information. Moreover, the hydrogel possessed an excellent conductivity of 0.43 S/m, and the hydrogel could transform large/subtle deformation and temperature information into electrical signal change. Thus, the ultrafast strain/temperature-sensitive conductivity allowed the hydrogel to quantitatively detect large/small-scale human motions as well as environmental temperature. A cytotoxicity test confirmed the good cytocompatibility. Taken together, the hydrogel was suitable for human motion detecting and environmental information harvesting for long time periods. Therefore, the hydrogel has a great application potential as a multifunctional ionic skin and smart sensor.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Multistimuli-Responsive PNIPAM-Based Double Cross-Linked Conductive Hydrogel with Self-Recovery Ability for Ionic Skin and Smart Sensor

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The band at 1083 cm −1 and 3696 cm −1 can be assigned to Mg\ \O stretching vibration. The MCT-DC composite scaffolds presented the characteristic peaks of DC at 3388, 3000, and 2950 cm − 1 which are related to OH, N\ \H, and C\ \H stretching vibrations, respectively [37,38]. The bands at 1745 and 1451 cm −1 are attributed to the amide (N\ \H) bending and aromatic N\ \H bending vibrations, respectively.…”

Section: Resultsmentioning

confidence: 98%

“…The bands at 1745 and 1451 cm −1 are attributed to the amide (N\ \H) bending and aromatic N\ \H bending vibrations, respectively. Multiple peaks between 1400 and 1700 cm − 1 are related to aromatic C_O and C_C stretching [37,38]. Furthermore strong peak at 1557 cm −1 related to the aromatic N\ \H bending.…”

Section: Resultsmentioning

confidence: 99%

Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO2 composite scaffold

et al. 2018

View full text Add to dashboard Cite

Mg-Ca-TiO 2 composite scaffold loaded with different concentrations of doxycycline were prepared by space holder method. • Mg-based scaffold containing doxycycline possesses compressive strength of 5 MPa with porosities of 65%. • Antimicrobial activity of the composite scaffold increased with increasing doxycycline concentration. • Mg-based composite scaffolds containing low concentrations of doxycycline showed good biocompatibility. • These composite scaffolds showed good biological properties and desired drug release trend for bone infection treatment.

show abstract

“…Melt granulation using a twin-screw extruder emerged as a robust technology for the development of modified-release oral formulations for high-dose and highly water-soluble actives. Although natural polymers such as guar gum [36,37]; gum acacia [38], etc. ; and waxy binders such as polyethylene glycol [39] were conventionally used for controlled-release formulations, polymeric binders provide a better control over granule properties in twin-screw melt granulation [10].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride: Effect of Rheological Properties of Polymer on Melt Granulation and Granule Properties

et al. 2021

View full text Add to dashboard Cite

High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt granulation due to processability difficulties at low operating temperatures and potential drug degradation if high processing temperatures are used. Conversely, high-molecular-weight grade HPC (Klucel®) can be used in melt granulation processes. The purpose of this study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. Powder blends were prepared with 75% w/w metformin HCl and 25% w/w polymeric binder. Blends were granulated at processing temperatures of 160, 140, 120 and 100 °C. HPMC HME 4M (Affinisol® 4M) provided a fine powder, indicating minimum granulation at processing temperatures lower than 160 °C, and the tablets obtained with these granules capped during tableting. In contrast, acceptable tablets could be obtained with HPC GXF at all processing temperatures. Rheological studies including capillary rheometry to measure steady shear rate viscosity, and rotational rheometry to obtain time and temperature superposition data, showed that HPC GXF had a greater thermoplasticity than HPMC HME 4M, which made granulation possible with HPC GXF at low temperatures. Tablets compressed with granules obtained at 160 °C with both binders showed comparable dissolution profiles. High-molecular-weight HPC GXF provided a better processability at low temperatures and adequate tablet strength for the melt granulation of metformin HCl.

show abstract

Controlled release of Doxycycline from gum acacia/poly(sodium acrylate) microparticles for oral drug delivery

Cited by 25 publications

References 19 publications

Multistimuli-Responsive PNIPAM-Based Double Cross-Linked Conductive Hydrogel with Self-Recovery Ability for Ionic Skin and Smart Sensor

Multistimuli-Responsive PNIPAM-Based Double Cross-Linked Conductive Hydrogel with Self-Recovery Ability for Ionic Skin and Smart Sensor

Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO2 composite scaffold

Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride: Effect of Rheological Properties of Polymer on Melt Granulation and Granule Properties

Contact Info

Product

Resources

About