Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

Azizi, Hossein; Hwang, Jeng Jong; Suen, Vivian M.M.; Kang, Nan; Somvanshi, Rishi K.; Tadavarty, Ramakrishna; Kumar, Ujendra; Sastry, B.R.

doi:10.1016/j.neulet.2017.06.053

Cited by 13 publications

(14 citation statements)

References 37 publications

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“…However, fluctuations also vary with factors such as sex, age, BMI, genetic status, temperature, season, and humidity [145146147]. Several mechanisms could be involved, and evidence is present for sleep-related changes in monoamine synthesis [148149], degradation [150151152153154], receptors and transporters [148155] and binding [156157].…”

Section: Discussionmentioning

confidence: 99%

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Menon¹,

Nolten²,

Achterberg³

et al. 2019

Journal of Circadian Rhythms

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Disruption of the monoaminergic system, e.g. by sleep deprivation (SD), seems to promote certain diseases. Assessment of monoamine levels over the circadian cycle, during different sleep stages and during SD is instrumental to understand the molecular dynamics during and after SD. To provide a complete overview of all available evidence, we performed a systematic review. A comprehensive search was performed for microdialysis and certain monoamines (dopamine, serotonin, noradrenaline, adrenaline), certain monoamine metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5-HIAA)) and a precursor (5-hydroxytryptophan (5-HTP)) in PubMed and EMBASE. After screening of the search results by two independent reviewers, 94 publications were included. All results were tabulated and described qualitatively. Network-meta analyses (NMAs) were performed to compare noradrenaline and serotonin concentrations between sleep stages. We further present experimental monoamine data from the medial prefrontal cortical (mPFC). Monoamine levels varied with brain region and circadian cycle. During sleep, monoamine levels generally decreased compared to wake. These qualitative observations were supported by the NMAs: noradrenaline and serotonin levels decreased from wakefulness to slow wave sleep and decreased further during Rapid Eye Movement sleep. In contrast, monoamine levels generally increased during SD, and sometimes remained high even during subsequent recovery. Decreases during or after SD were only reported for serotonin. In our experiment, SD did not affect any of the mPFC monoamine levels. Concluding, monoamine levels vary over the light-dark cycle and between sleep stages. SD modifies the patterns, with effects sometimes lasting beyond the SD period.

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Section: Discussionmentioning

confidence: 99%

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Menon¹,

Nolten²,

Achterberg³

et al. 2019

Journal of Circadian Rhythms

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“…The specificity of glycine antibody used is known from previous studies in the lamprey (Cinelli et al., 2016; Mahmood, Restrepo, & El Manira, 2009) and is consistent with the finding of glycine immunonegative areas, such as that corresponding to the anterior rhombencephalic reticular nucleus (see Figure 5b). The mouse monoclonal antibody against 5‐HT 1A Rs has been used in the mammalian central nervous system (Azizi et al., 2017; Iovino et al., 2019; Li et al., 2018; Millon et al., 2016). It has not been previously used in the lamprey.…”

Section: Methodsmentioning

confidence: 99%

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Cinelli

Mutolo

Iovino

et al. 2020

Eur J of Neuroscience

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In mammals, 5-HTexcitatory respiratory effects imply 5-HT 1A receptor-mediated disinhibition of pre-Bötzinger complex neurons. In the lamprey, 5-HT 1A receptors are involved in the neural control of locomotion, but their role in the respiratory regulation, particularly at the level of the putative respiratory rhythm generator, the paratrigeminal respiratory group (pTRG), is not known. We here investigate the respiratory function of inhibitory 5-HT 1A receptors within the pTRG of the isolated brainstem of the adult lamprey. The 5-HT 1A receptor agonists either bath applied or microinjected into the pTRG did not cause significant effects. However, the selective 5-HT 1A receptor antagonist (S)-WAY 100135 bath applied or microinjected into the pTRG induced depressing respiratory effects or even apnoea, thus revealing that 5-HT exerts a 5-HT 1A receptor-mediated potent tonic influence on respiration and contributes to maintain baseline levels of respiratory activity. Microinjections of strychnine or bicuculline, either alone or in combination, into the pTRG prevented (S)-WAY 100135-induced apnoea. In addition, immunohistochemical studies corroborate the present findings suggesting that 5-HT 1A receptors are widely expressed in close apposition to the soma of glycine-immunoreactive cells located within the pTRG region. The results show that in the lamprey respiratory network, 5-HT exerts a tonic influence on respiration by a potent inhibitory control on both GABAergic and glycinergic mechanisms. The observed disinhibitory effects resemble the excitatory respiratory modulation exerted by 5-HT 1A receptor-mediated inhibition of glycinergic and/or GABAergic neurons present in mammals, supporting the notion 3904 | CINELLI Et aL.

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“…In many studies related to SD, a close correlation between SD and depression has been established. Some researches demonstrated a positive connection, saying that SD could weaken depressive symptoms [ 28 , 29 ], while others are on the opposite [ 30 , 31 ]. Here, we applied the FST and TST to evaluate depressive symptoms of the rats.…”

Section: Discussionmentioning

confidence: 99%

Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chronic Sleep Deprivation Using Gas Chromatography-Mass Spectrometry

Zhou

Gou

et al. 2018

International Journal of Genomics

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The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform group (BP), sleep deprivation group (SD), and the CGA (model + CGA), and CGA group was much closer to the BP group by showing a tendency of recovering towards BP group. Thirty-six significantly changed metabolites related to antidepressant by CGA were identified and used to explore the potential mechanism. Combined with the result of the classic behavioral tests and biochemical indices, CGA has significant antidepressant effects in a rat model of SD, suggesting that the mechanism of action of CGA might be involved in regulating the abnormal pathway of nicotinate and nicotinamide metabolism; glyoxylate and dicarboxylate metabolism; glycine, serine, and threonine metabolism; and arginine and proline metabolism. Our results also show that metabolomics analysis based on GC-MS is a useful tool for exploring biomarkers involved in depression and elucidating the potential therapeutic mechanisms of Chinese medicine.

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Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

Cited by 13 publications

References 37 publications

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chronic Sleep Deprivation Using Gas Chromatography-Mass Spectrometry

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Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

Cited by 13 publications

References 37 publications

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Key role of 5‐HT1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chronic Sleep Deprivation Using Gas Chromatography-Mass Spectrometry

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Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys