Pre‐Dialysis Neutrophil‐Lymphocyte Ratio, a Novel and Strong Short‐Term Predictor of All‐Cause Mortality in Patients With Diabetic Nephropathy: Results From a Single‐Center Study

Sato, Hiroyuki; Takeuchi, Yoichi; Matsuda, Ken; Kagaya, Saeko; Saito, Ayako; Fukami, Hirotaka; Ojima, Yoshie; Nagasawa, Tasuku

doi:10.1111/1744-9987.12533

Cited by 13 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pre-dialysis neutrophil-lymphocyte ratio (NLR) is a novel and strong short-term predictor for all-cause mortality in HD patients[ 27 ]. NLR has been shown to have predictive utility in numerous disease states, including acute myocardial infarction and autoimmune disease[ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

“…NLR represents systemic inflammation, nutritional status, and atherosclerosis, which are all prevalent in CKD patients[ 76 , 77 ]. One single-center Japanese cohort revealed that NLR is superior to other generic biomarkers for 1-year survival among patients with ESKD due to diabetic nephropathy[ 27 ]. Although the usefulness of NLR has been widely studied in CKD patients, more data on its accuracy in diverse CKD patients are needed.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of mortality among patients with chronic kidney disease: A systematic review

Hansrivijit

Chen

Lnu

et al. 2021

WJN

View full text Add to dashboard Cite

BACKGROUND Chronic kidney disease (CKD) is a common medical condition that is increasing in prevalence. Existing published evidence has revealed through regression analyses that several clinical characteristics are associated with mortality in CKD patients. However, the predictive accuracies of these risk factors for mortality have not been clearly demonstrated. AIM To demonstrate the accuracy of mortality predictive factors in CKD patients by utilizing the area under the receiver operating characteristic (ROC) curve (AUC) analysis. METHODS We searched Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible articles through January 2021. Studies were included based on the following criteria: (1) Study nature was observational or conference abstract; (2) Study populations involved patients with non-transplant CKD at any CKD stage severity; and (3) Predictive factors for mortality were presented with AUC analysis and its associated 95% confidence interval (CI). AUC of 0.70-0.79 is considered acceptable, 0.80-0.89 is considered excellent, and more than 0.90 is considered outstanding. RESULTS Of 1759 citations, a total of 18 studies ( n = 14579) were included in this systematic review. Eight hundred thirty two patients had non-dialysis CKD, and 13747 patients had dialysis-dependent CKD (2160 patients on hemodialysis, 370 patients on peritoneal dialysis, and 11217 patients on non-differentiated dialysis modality). Of 24 mortality predictive factors, none were deemed outstanding for mortality prediction. A total of seven predictive factors [N-terminal pro-brain natriuretic peptide (NT-proBNP), BNP, soluble urokinase plasminogen activator receptor (suPAR), augmentation index, left atrial reservoir strain, C-reactive protein, and systolic pulmonary artery pressure] were identified as excellent. Seventeen predictive factors were in the acceptable range, which we classified into the following subgroups: predictors for the non-dialysis population, echocardiographic factors, comorbidities, and miscellaneous. CONCLUSION Several factors were found to predict mortality in CKD patients. Echocardiography is an important tool for mortality prognostication in CKD patients by evaluating left atrial reservoir strain, systolic pulmonary artery pressure, diastolic function, and left ventricular mass index.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prediction of mortality among patients with chronic kidney disease: A systematic review

Hansrivijit

Chen

Lnu

et al. 2021

WJN

View full text Add to dashboard Cite

show abstract

“…A total of 1048 potentially relevant studies were obtained from electronic databases and citations of reference lists, out of which 10 cohort studies [12,[21][22][23][24][25][26][27][28][29] from 5 countries met the inclusion criteria. Three of the studies were conducted in China.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio in relation to the risk of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis

2020

View full text Add to dashboard Cite

show abstract

“…In patients with CKD, the NLR and PLR predict disease progression and the presence of albuminuria (19,20). Although several studies have suggested that both markers also predict mortality in patients with CKD, there are contradictory results (21), they are studies done in dialysis patients (22,23), or patients with CKD in stages 1-5, but in Asian population (24). Because mortality and associated factors differ according to the stage of the disease and in Hispanic population (25)(26)(27), this study aims to assess the association between NLR and PLR with all-cause mortality in Peruvian patients with CKD who was attending tertiary hospital.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a risk factor for mortality in peruvian adults with chronic kidney disease.

Umeres-Francia

Rojas-Fernández

Herrera-Añazco

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: To assess the association between NLR and PLR with all-cause mortality in Peruvian patients with CKD Methods: We conducted a retrospective cohort study in adults with CKD in stages 1 to 5. The outcome variable was mortality and as variables of exposure to NLR and PLR. Both ratios were categorized as high with a cut-off point of 3.5 and 232.5; respectively. We carried out a Cox regression model and calculated crude and adjusted hazard ratios (HR) with their 95% confidence interval (95%CI). Results: We analyzed 343 participants with a median follow-up time of 2.45 years (2.08-3.08). The frequency of deaths was 17.5% (n=60). In the crude analysis, the high NLR and PLR were significantly associated with all-cause mortality (HR=2.01; 95% CI:1.11-3.66) and (HR=2.58; 95% CI:1.31-5.20). In the multivariate model, after adjusting for age, sex, serum creatinine, CKD stage, albumin and hemoglobin, the high NLR and PLR remained as an independent risk factor for all-cause mortality, (HR=2.10; 95% CI:1.11-3.95) and (HR=2.71; 95% CI:1.28-5.72). Conclusion: Our study suggests the relationship between high NLR and PLR with all-cause mortality in patients with CKD.

show abstract

Pre‐Dialysis Neutrophil‐Lymphocyte Ratio, a Novel and Strong Short‐Term Predictor of All‐Cause Mortality in Patients With Diabetic Nephropathy: Results From a Single‐Center Study

Cited by 13 publications

References 27 publications

Prediction of mortality among patients with chronic kidney disease: A systematic review

Prediction of mortality among patients with chronic kidney disease: A systematic review

Neutrophil-to-lymphocyte ratio in relation to the risk of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a risk factor for mortality in peruvian adults with chronic kidney disease.

Contact Info

Product

Resources

About