Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (<scp>HA</scp>122) in infantile colic: An open randomized controlled trial

Martinelli, Massimo; Ummarino, Dario; Giugliano, Francesca Paola; Sciorio, Elisa; Tortora, Chiara; Bruzzese, Dario; Giovanni, Donatella De; Rutigliano, Irene; Valenti, S; Romano, Claudio; Campanozzi, Angelo; Miele, Erasmo; Staiano, Annamaria

doi:10.1111/nmo.13145

Cited by 36 publications

(32 citation statements)

References 37 publications

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“…All included studies were double-blind randomized placebo-controlled trials of high quality. Lower-quality studies were excluded, such as the 2015 Mi et al 37 study, which was single-blind, and the 2015 Ashraf et al 38 and 2017 Martinelli et al 39 studies, which were nonblinded.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis

et al. 2018

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“…This meta-analysis of 16 clinical trials and 1319 newborns exclusively investigated the impact of solely-probiotic interventions to reduce excessive crying in newborns manifesting symptoms of infantile colic, with no limitations on the age of study participants, and also gives a report on microbiota-related parameters affected by probiotics. Studies in which lactase, simethicone/herbal preparations or hydrolyzed formulas were utilized as probiotic comparators were not analyzed, as these interventions have their own evidence-based efficacy [59][60][61][62][63][64]. We also did not evaluate trials conducted with newborns who were not delivered at term, as premature newborns have been found to present immaturity in their digestive motility and interstitial Cajal cells [65] and are thus more prone to manifest behavioral perturbations [66].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Skonieczna-Żydecka

Janda

Kaczmarczyk

et al. 2020

JCM

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Immaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a clinical trials registry (ClinicalTrials.gov) were searched from inception until 12/02/2020. Random-effects meta-analyses were used to derive standardized mean differences/differences in means and risk ratios. We included 16 studies, which involved 1319 newborns aged up to 6 months. Lactobacillus reuteri strain DSM17938 was administered predominantly (n = 10). Probiotic intervention reduced the duration of crying (standardized mean difference = −2.012, 95% confidence interval: −2.763 to −1.261, z = −5.25, p < 0.0001). The probability of at least a 50% reduction in crying duration was at least 1.98 times higher in the intervention group than in controls (Z = 4.80, p < 0.0001). The effects of the intervention were not significantly affected by the risk of bias assessment, percentage of breastfed infants, and duration of the study. In 11 studies, data concerning gut microbiota composition and function and/or immunological markers were given. Probiotics significantly shortened the crying duration, but a causal relationship between the modulatory effect of probiotics on microbiota and the immune system has not been confirmed.

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“…However due to dissatisfaction with the conventional therapeutic methods to control the infantile colic, the mothers are currently interested in herbal medicines to calm their babies colic (13). Also, herbal medicines used in the treatment of infantile colic are associated with fewer side effects.…”

Section: Contextmentioning

confidence: 99%

“…open-label, randomized, and controlled trial (13). Diagnosis was made according to the Rome III criteria.…”

Section: Martinelli Et Al Performed a Prospective Multicentermentioning

confidence: 99%

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Effectiveness of Herbal Medicines Containing Phytoestrogens to Treat Infantile Colic: A Meta-analysis Review

Mohammadi

Ghazanfarpour

Kargarfard

et al. 2018

JPR

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Context: Due to the dissatisfaction with the conventional therapeutic methods to control the infantile colic, the mothers are developing interest in herbal medicines. Objectives: The present study is a systematic review with meta-analysis which was conducted to evaluate the effect of herbal medicines in the treatment of infantile colic. Data Sources: A systematic electronic search was performed on the databases of the MEDLINE, Scopus and the Cochrane Central Register Trials inception up to July 2018 to assess the effectiveness of herbal medicines in the treatment of infantile colic. No determined limitation was considered and the measured outcome was the duration of crying time. Study Selection: Six studies assessed the effect of herbal medicine on colic infantile Data Extraction: The data extraction and quality assessment of the trials were performed by two separate individuals based on standardized predefined checklist. Results: Five studies investigated the effect of prepared herbal medicines containing phytoestrogens on the infantile colic, the colic improvement score, and the number of night waking times. The compounds containing phytoestrogens decreased the duration of crying time compared to placebo (SMD=-0.536; 95% CI=-0.848 to 0.224; P=0.001). Heterogeneity was moderate but not statistically significant (I2=56%; P=0.07). Moreover, one study measured the colic improvement score and the number of night wakings whose results showed a significant decrease in the parameters. To sum up, the phytoestrogens could significantly improve the infantile colic. Four trials studied the effect of compounds containing fennel, as their results indicated a significant improvement in the duration of crying time compared to control group (SMD=O.712; 95% CI=-1.005 to 0.420; P<0.001). Heterogeneity was 0% among the studies. The SMD of compounds containing fennel alone reduced the duration of crying time to less than-0.6 (95% CI=-0.940 to-0.456; P<0.001). Heterogeneity was moderate but not statistically significant (I2=0%; P=0.669). Conclusions: Fennel and compounds containing phytoestrogens had a significant positive effect on the duration of crying time. Mentha piperita was shown to possess higher efficacy than simethicone in reducing daily colic duration. Further trials should be conducted with larger sample size and longer treatment duration.

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Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial

Cited by 36 publications

References 37 publications

Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis

Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis

The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Effectiveness of Herbal Medicines Containing Phytoestrogens to Treat Infantile Colic: A Meta-analysis Review

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