<i>Retracted:</i> microRNA‐145‐3p inhibits non‐small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway

Chen, Guimin; Zheng, A-Juan; Cai, Jing; Han, Ping; Ji, Hongbo; Wang, Lele

doi:10.1002/jcb.26252

Cited by 26 publications

(24 citation statements)

References 35 publications

(72 reference statements)

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“…Among them, miR-145 plays a suppressive role in tumor progression and is involved in tumorigenesis. Furthermore, miR-145 with anticancer effect was identified in ovarian carcinoma ( 23 ), colorectal carcinoma ( 24 ) and non-small cell lung cancer ( 25 ). The same conclusion for BC was obtained in this study.…”

Section: Discussionmentioning

confidence: 99%

miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

et al. 2018

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MicroRNA-145-5p (miR-145-5p) is found to be involved in tumor development and progression. However, there are few studies on the effects of miR-145-5p on bladder cancer (BC). The role of miR-145-5p in BC was predicted by analysis of cell proliferation and migration in this study. The miR-145-5p and transgelin-2 (TAGLN2) expressions were evaluated via reverse transcription-quantitative PCR (RT-qPCR) or western blot analysis. The MTT and Transwell assay assessed cell proliferation and migration. TAGLN2 targeted to miR-145-5p was determined using luciferase assays. The results showed that the miR-145-5p downregulation was found in BC. miR-145-5p overexpression inhibited cell proliferation and migration in BC. Moreover, miR-145-5p directly targeted TAGLN2, and TAGLN2 expression was increased in BC. In addition, the high expression of TAGLN2 promoted cell proliferation and migration in BC. miR-145-5p appeared to regulate TAGLN2 in BC, and it also inhibited the cell proliferation and migration. The novel miR-145-5p/TAGLN2 axis may provide new therapeutic implications for BC.

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Section: Discussionmentioning

confidence: 99%

miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

et al. 2018

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“…Our previous studies demonstrated that antitumor miR-145-3p directly targeted oncogenes, e.g., MTDH in lung adenocarcinoma, UHRF1 in bladder cancer, MYO1B in head and neck cancer and MELK, NCAPG, BUB1 and CDK1 in prostate cancer (17)(18)(19)(20). Another group demonstrated that miR-145-3p inhibited cell growth, motility and chemotaxis in non-small cell lung cancer by targeting pyruvate dehydrogenase kinase 1 through suppressing the mechanistic target of rapamycin pathway (37). These findings indicated that antitumor miR-145-3p is associated with cancer pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation

et al. 2018

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Although miR-145-5p (the guide strand of the miR-145 duplex) is established as a tumor suppressive microRNA (miRNA or miR), the functional significance of miR-145-3p (the passenger strand of the miR-145 duplex) in cancer cells and its targets remains obscure. In our continuing analysis of esophageal squamous cell carcinoma (ESCC) pathogenesis, the aim of the present study was to identify important oncogenes and proteins that are controlled by miR-145-3p. Overexpression of miR-145-3p significantly reduced cancer cell proliferation, migration and invasive abilities, and further increased apoptotic abilities. In ESCC cells, 30 possible oncogenic targets were identified that might be regulated by miR-145-3p. Among these targets, dehydrogenase/reductase member 2 (DHRS2) and myosin IB (MYO1B) were focused on to investigate their functional roles in ESCC cells. DHRS2 and MYO1B were directly regulated by miR-145-3p in ESCC cells by dual luciferase reporter assays. Aberrantly expressed DHRS2 and MYOIB were detected in ESCC clinical specimens, and their overexpression enhanced cancer cell aggressiveness. Genes regulated by antitumor miR-145-3p were closely associated with the molecular pathogenesis of ESCC. The approach based on antitumor miRNAs may contribute to the understanding of ESCC molecular pathogenesis.

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“…miRNAs have been reported to modulate cancer progression and are considered as potential biomarkers for diagnosis, pathogenesis and progression prediction, as well as therapy in numerous cancers, including lung cancer, breast cancer, thyroid carcinoma and colorectal cancer (13)(14)(15)(16). Particularly, miRNA-145 exerts a regulatory effect on multiple types of human tumors, including colorectal cancer, non-small cell lung cancer, pancreatic cancer and oral cancer (17)(18)(19)(20). Nevertheless, the underlying mechanism of miRNA-145-mediated modulation of migration and invasion of BC cells remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin

Zhang

Chang

et al. 2018

Mol Med Report

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MicroRNA (miRNA)‑145 has been demonstrated to serve a role in several types of tumors, however, the potential molecular mechanism of action of miRNA‑145 in bladder cancer metastasis remains to be elucidated. This study aimed to investigate the potential modulation of miRNA‑145 in bladder carcinoma and elucidate the underlying molecular mechanism. The expression of miRNA‑145 in bladder adenocarcinoma tissues and bladder cancer cells was measured by reverse transcription‑quantitative polymerase chain reaction. miRNA‑145 mimics and inhibitor were transfected into bladder cancer (BC) cells to determine the role of miRNA‑145 on cell motility and invasion measured by wound healing and transwell assays. Luciferase assay was performed to confirm whether N‑cadherin was the direct target of miRNA‑145. Subsequently, expression of N‑cadherin and matrix metalloproteinase‑9 (MMP9) in BC cells were detected by western blot analysis. miRNA‑145 was significantly downregulated cells and tissues from patients with BC, compared with healthy controls. miRNA‑145 markedly inhibited the ability of BC cells to migrate and invade. Furthermore, N‑cadherin was identified as a target of miRNA‑145 in BC cells. MMP9, acting downstream of N‑cadherin, was downregulated in BC cells by miRNA‑145. In the present study, miRNA‑145 suppressed the migration and invasion of BC cells by regulating N‑cadherin. The results of the present study indicated that miRNA‑145 may function as a tumor suppressor and may have a potential to be a diagnostic and predictive biomarker, and a therapeutic target for treatment of BC.

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Retracted: microRNA‐145‐3p inhibits non‐small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway

Cited by 26 publications

References 35 publications

miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation

microRNA‑145 modulates migration and invasion of bladder cancer cells by targeting N‑cadherin

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