An analysis of genetic association in opioid dependence susceptibility

Abstract

The results indicate that SNPs rs1042114 and rs910080 contribute to vulnerability to opioid dependence in the Malaysian Malay population. These results will help us to understand the effect of the SNPs and the SNP-SNP interaction on opioid dependence and may assist in efforts to screen vulnerable individuals and match them with individually tailored prevention and treatment strategies.

Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

“…Data synthesis for rs910080 was available on six studies [12][13][14][15][16][17] with seven independent cohorts including 3092 cases and 3136 controls. Due to considerable heterogeneity, random-effect model was employed with the exception of heterozygous model.…”

“…Another 4 ineligible articles were erased after comprehensive assessment according to inclusion and exclusion criteria. Ultimately, 7 articles [12][13][14][15][16][17][18] were included in qualitative synthesis and meta-analysis. The process was displayed in Fig.…”

“…A total of seven case-control studies [12][13][14][15][16][17][18] with 3129 cases and 3289 controls were included in the meta-analysis. Of the included studies, six [12][13][14][15][16]18] were published in English and one [17] was in Chinese. It should be noted that Clarke et al's study [15] published in 2012 consisted of two different cohorts.…”

“…Since Zimprich et al [11] initially reported the correlation between PDYN gene polymorphisms and OD, several researchers have subsequently replicated with inconsistent results [12][13][14][15][16][17][18]. The lack of convergent findings might ascribe to weak statistical power to ascertain a significant effect, population structure or betweenstudy heterogeneity.…”

Pharmacogenetics of Opioid Use and Implications for Pain Management—Are We Ready?

“…OPRD1 and PDYN variants (9). Regardless of these pharmacogenetics associations, there are numerous studies that demonstrate changes in gene expression, and epigenetic modifications are important to the pathogenesis and persistence of addiction (10).…”