Reference values of lithium in postmortem femoral blood

Söderberg, Carl; Wernvik, Emma; Jönsson, Anna K.; Druid, Henrik

doi:10.1016/j.forsciint.2017.06.007

Cited by 7 publications

(4 citation statements)

References 131 publications

(165 reference statements)

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“…Table shows the comparison of selected concentration percentiles in PM femoral venous blood between the present study, involving all causes of death ( N = 144 034), and the five Swedish studies ( N = 9436), employing grouping according to the cause of death . A moderate correspondence was obtained between Swedish group C and our median concentration, both representing a “normal” PM concentration.…”

Section: Resultsmentioning

confidence: 62%

“…Comparison to the PM concentrations from the Swedish investigators' studies was based on the following concentration percentile ratios obtained from the two databases (Swedish/Finnish): median/median, 90th percentile/median, 90th/90th percentile, and 90th/97.5th percentile. First, the concentration percentile ratios were calculated for individual drugs, and second, the medians of these ratios were calculated and presented in Table .…”

Section: Methodsmentioning

confidence: 99%

“…Grouping of cases in Swedish studies: A, poisonings by one specific substance only, B, multi‐substance poisonings, C, PM controls consisting of deaths not involving incapacitation by substances…”

Section: Methodsmentioning

confidence: 99%

“…In most cases, the C plasma values represented the upper limit of plasma/serum concentrations (in general, trough concentration at steady state) observed following therapeutically effective doses. 43 Comparison to the PM concentrations from the Swedish investigators' studies [44][45][46][47][48] was based on the following concentration percentile ratios obtained from the two databases (Swedish/Finnish):…”

Section: Comparison To Literature Reference Concentrationsmentioning

confidence: 99%

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Summary statistics for drug concentrations in post‐mortem femoral blood representing all causes of death

Ketola

Ojanperä

2019

Drug Testing and Analysis

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Concentration distributions for 183 drugs and metabolites frequently found in post‐mortem (PM) femoral venous blood were statistically characterized based on an extensive database of 122 234 autopsy cases investigated during an 18‐year period in a centralized laboratory. The cases represented all causes of death, with fatal drug poisonings accounting for 8%. The proportion of males was 74% with a median age of 58 years compared with 26% females with a median age of 64 years. In 36% of these cases, blood alcohol concentration was higher than or equal to 0.2‰, the median being 1.6‰. The mean, median, and upper percentile (90th, 95th, 97.5th) drug concentrations were established, as the median PM concentrations give an idea of the “normal” PM concentration level, and the upper percentile concentrations indicate possible overdose levels. A correspondence was found between subsets of the present and the previously published PM drug concentrations from another laboratory that grouped cases according to the cause of death. Our results add to the knowledge for evidence‐based interpretation of drug‐related deaths.

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Section: Resultsmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Comparison To Literature Reference Concentrationsmentioning

confidence: 99%

See 2 more Smart Citations

Summary statistics for drug concentrations in post‐mortem femoral blood representing all causes of death

Ketola

Ojanperä

2019

Drug Testing and Analysis

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Pharmacokinetics

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Drug level monitoring, when appropriately used, is of considerable help in optimising treatment and assuring adherence. In psychiatry, target ranges for psychotropic drug concentrations should be treated with some caution. Plasma levels of olanzapine are linearly related to daily dose, but there is substantial variation, with higher levels seen in women, non‐smokers and those on enzyme inhibiting drugs. Postmortem redistribution tends to be greater with drugs with a large volume of distribution especially when given over a long period during life. In most developed countries, clozapine blood concentration monitoring is widely used. Information on the effect of drugs on cytochrome function helps predict or confirm suspected interactions which may not have been uncovered in regulatory trials or in clinical use. The effects of polymorphism and pharmacokinetic interaction are difficult to predict because some drugs are metabolised by more than one enzyme and an alternative pathway(s) may compensate if other enzyme pathways are inhibited.

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Multiple drugs

2017

Reactions Weekly

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Reference values of lithium in postmortem femoral blood

Cited by 7 publications

References 131 publications

Summary statistics for drug concentrations in post‐mortem femoral blood representing all causes of death

Summary statistics for drug concentrations in post‐mortem femoral blood representing all causes of death

Pharmacokinetics

Multiple drugs

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