Microcystic Adnexal Carcinoma: A Review of the Literature

Abstract

Microcystic adnexal carcinoma is a locally aggressive disease with histological margins that often far surpass what is clinically suspected. Mohs micrographic surgery is the standard of care for removal of these lesions. Patients with a history of MAC should be examined at least every 6 months for recurrence, metastasis, and development of additional skin cancers.

Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple

“…With respect to malignant skin adnexal tumours the most closely related tumours are syringoid carcinoma and microcystic adnexal carcinoma [15]. These tumours morphologically resemble SyT since they have features of both eccrine and follicular differentiation [16], but the presence of keratinous cysts and perineural growth pattern are more dominant in these lesions as compared to SyT. Syringoid carcinoma and microcystic adnexal carcinoma have the capacity to metastasize and follow-up is mandatory after local resection.…”

Axillary and elbow lymph node metastasis arising after complete excision of microcystic adnexal carcinoma of a hand: A rare presentation

“…A plausible explanation for the recurrence in this patient might be that the complex structure of a hand, the malignant cells could also spread via tendon, sheath or palmar bursa that may require wider excision than that in the head and neck regions. In addition, Mohs micrographic surgery, a precise form of tissue sparing with microscopically controlled surgery, was reported to have much lower recurrent rate (0–12%) [11,12]. This may be due to the technique of surgery that requires examination of all margins of the tumor.…”

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

“…MAC presents as an asymptomatic, smooth, non-ulcerated, white or yellowish papule, plaque, or nodule. The lesion typically occurs in the head and neck region [ 42 , 45 ]. Histologically, MAC is typically well-differentiated and deeply penetrating, although it may exhibit subclinical lateral spread.…”