Screening for Syphilis and Other Sexually Transmitted Infections in Pregnant Women — Guam, 2014

Cha, Susan; Malik, Tasneem; Abara, Winston E.; DeSimone, Mia S.; Schumann, Bernadette; Mallada, Esther; Klemme, Michael; Aguon, Vince; Santos, Anne Marie; Peterman, Thomas A.; Bolan, Gail; Kamb, Mary L.

doi:10.15585/mmwr.mm6624a4

Cited by 9 publications

(16 citation statements)

References 7 publications

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“…However, not all pregnant women in the study reported for a prenatal check early in pregnancy; therefore, complete treatment for syphilis could not be given to all women who were affected. This trend has been reported in other regions of the world . Failure of pregnant women to report for prenatal care early in pregnancy is a pitfall of the current strategy to eradicate congenital syphilis.…”

Section: Discussionmentioning

confidence: 63%

“…A comparison of the present results with those of Mathai et al., who reported a prevalence of 0.98% and 0.38% for VDRL positivity and syphilis, respectively, in 2001, indicates that there has been small reduction in the prevalence of syphilis in pregnancy among patients at the Christian Medical College Hospital over the past decade. This trend is reassuring because a very significant increase in the prevalence of syphilis in women (as high as 473%) was recorded between 2009 and 2013 in other parts of the world …”

Section: Discussionmentioning

confidence: 93%

“…WHO have suggested that screening 90% of pregnant women for syphilis and treating 90% of those affected would help to eradicate congenital syphilis . Although screening for syphilis in pregnancy is mandated by law in some countries, universal screening has not been successfully introduced . Universal screening for syphilis is performed at the present study center, thereby fulfilling the first criterion of the WHO outline.…”

Section: Discussionmentioning

confidence: 99%

“…This trend is reassuring because a very significant increase in the prevalence of syphilis in women (as high as 473%) was recorded between 2009 and 2013 in other parts of the world. 5,10 It is generally accepted that congenital syphilis can be prevented by screening prenatally for syphilis and promptly treating affected women with penicillin as early in pregnancy as possible. 1 WHO have suggested that screening 90% of pregnant women for syphilis and treating 90% of those affected would help to eradicate congenital syphilis.…”

Section: Discussionmentioning

confidence: 99%

“…11 Although screening for syphilis in pregnancy is mandated by law in some countries, universal screening has not been successfully introduced. 10 Universal screening for syphilis is performed at the present study center, thereby fulfilling the first criterion of the WHO outline. However, not all pregnant women in the study reported for a prenatal check early in pregnancy; therefore, complete treatment for syphilis could not be given to all women who were affected.…”

Section: Discussionmentioning

confidence: 99%

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A retrospective study of the prevalence and outcomes of syphilis in pregnancy in a 5‐year period

Ebenezer

Benjamin

Sahni

et al. 2017

Intl J Gynecology & Obste

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Objective: To determine the prevalence of syphilis in pregnancy and to assess the effect of syphilis on maternal and perinatal outcomes. Methods:In a retrospective study, data were reviewed for pregnant women who Results: Among 51 164 pregnant women who underwent VDRL testing during the study period, 343 women were VDRL-positive (seropositivity rate 0.7%) and 18 were both VDRL-and TPHA-positive and were considered to have syphilis (seropositivity rate <0.1%). Among these 18 women, there were two stillbirths, four preterm births, and five small-for-gestational-age neonates. Conclusion:Although the prevalence of syphilis was low in the study population, women who were affected had adverse perinatal outcomes. Routine screening of all pregnant women for syphilis as early as possible in pregnancy, with appropriate treatment and follow-up of affected women and newborns, should be done to reduce adverse pregnancy outcomes. K E Y W O R D S

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A retrospective study of the prevalence and outcomes of syphilis in pregnancy in a 5‐year period

Ebenezer

Benjamin

Sahni

et al. 2017

Intl J Gynecology & Obste

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show abstract

Progress towards triple elimination of mother-to-child transmission of HIV, hepatitis B and syphilis in Pacific Island Countries and Territories: a systematic review

Bell¹,

Gemert²,

Allard³

et al. 2023

The Lancet Regional Health - Western Pacific

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Biological feasibility and importance of a gonorrhea vaccine for global public health

Vincent

Jerse

2019

Vaccine

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There is a growing public health interest in controlling sexually transmitted infections (STIs) through vaccination due to increasing recognition of the global disease burden of STIs and the role of STIs in women's reproductive health, adverse pregnancy outcomes, and the health and well-being of neonates. Neisseria gonorrhoeae has historically challenged vaccine development through the expression of phase and antigenically variable surface molecules and its capacity to cause repeated infections without inducing protective immunity. An estimated 78 million new N. gonorrhoeae infections occur annually and the greatest disease burden is carried by low- and middle-income countries (LMIC). Current control measures are clearly inadequate and threatened by the rapid emergence of antibiotic resistance. The gonococcus now holds the status of "super-bug" as there is currently no single reliable monotherapy for empirical treatment of gonorrhea. The problem of antibiotic resistance has elevated treatment costs and necessitated the establishment of large surveillance programs to track the spread of resistant strains. Here we review the need for a gonorrhea vaccine with respect to global disease burden and related socioeconomic and treatment costs, with an emphasis on the impact of gonorrhea on women and newborns. We also highlight the challenge of estimating the impact of a gonorrhea vaccine due to the need for more data on the burden of gonococcal pelvic inflammatory disease and related sequelae and of gonorrhea-associated adverse pregnancy outcomes and the problem of empirical diagnosis and treatment of STIs in LMIC. There is also a lack of clinical and basic science research in the area of gonococcal/chlamydia coinfection, which occurs in a high percentage of individuals with gonorrhea and should be considered when testing the efficacy of gonorrhea vaccines. Finally, we review recent research that suggests a gonorrhea vaccine is feasible and discuss challenges and research gaps in gonorrhea vaccine development.

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Screening for Syphilis and Other Sexually Transmitted Infections in Pregnant Women — Guam, 2014

Cited by 9 publications

References 7 publications

A retrospective study of the prevalence and outcomes of syphilis in pregnancy in a 5‐year period

A retrospective study of the prevalence and outcomes of syphilis in pregnancy in a 5‐year period

Progress towards triple elimination of mother-to-child transmission of HIV, hepatitis B and syphilis in Pacific Island Countries and Territories: a systematic review

Biological feasibility and importance of a gonorrhea vaccine for global public health

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