Effects of Copaiba Oil Topical Administration on Oral Wound Healing

Abstract

The effects of topical copaiba oil extract and topical corticosteroid were assessed on oral wound healing in an in vivo model using 96 male Wistar rats. Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool. The animals were divided into: Control; Corticosteroid; Placebo and Copaiba oil Group. The animals received two daily applications of the products. The control group received only daily handling. Six rats in each group were euthanized at days 3, 5, 10 and 14. The animals were monitored daily to determine wound status. The weigh was assessed at day 0 and euthanasia day. The percentage of repair was calculated, and histopathological aspects were analyzed. The Kruskal-Wallis test was used to compare the results between groups and times of evaluation. Closing time was assessed through the log-rank test. The corticosteroid group lost more weight at days 10 and 14 than the control group (p < 0.05). Moreover, the healing time of corticosteroid group was longer than the control group (p = 0.007). No differences were observed between the copaiba oil group and the control group. We concluded that topical copaiba oil, in spite of being safe, did not accelerate the process of oral wound healing. Copyright © 2017 John Wiley & Sons, Ltd.

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

“…These numbers initially demonstrate the potential of copaiba oil in the aid of the healing process. 11,12 Because of the benefits of applying copaiba oil as a topical use based on empirical evidence in the past, it is probable that the scientific community was influenced in researching the use of copaiba oil in the form most used by local Amazonian people, who used copaiba oil on the skin. According to Brito et al, 13 the practice of using medicinal plants is common in developing countries.…”

Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib

“…However, studies on commercial product safety reveal that this substance is not genotoxic or mutagenic [55,63] and has shown to be safe after topical application. [64] Altogether, the results obtained with formulation F4, composed of 2% Cxb and 25% C.O in PEG-400/PG, indicate that it is suitable for the treatment of superficial inflammation of the skin (including skin cancer induced by UVB) and inflammation process from rheumatoid arthritis. This formulation suppressed ear oedema more effectively than (1) those composed of other adjuvants to increase the cutaneous permeability of Cxb, such as 5% oleic acid and 5% monoolein, which inhibited ear oedema by 48.0 and 53.5%, respectively, and protein extravasation by 35.5 and 61.5%, respectively; [30] (2) microemulsions for topical application of Cxb, which suppressed ear oedema formation by 55.71 [65] or 61.43%.…”

“…To date, there are few reports in the literature related to the use of C.O as P.E (Quiñones et al ., 2017, epub ahead of print). However, studies on commercial product safety reveal that this substance is not genotoxic or mutagenic and has shown to be safe after topical application …”

Natural actives for wound healing: A review

“…Moreover, those actives were well known in folk culture, stimulating use. Nevertheless these are not the only actives being researched, and there are recent papers on Polygonum aviculare L. (Seo et al, ), Hancornia speciose (Geller et al, ), Caesalpinia sappan (Tewtrakul et al, ), Morus alba (Kim et al, ), and Copaiba oil (Wagner et al, ), for example.…”