Nodular cutaneous amyloidoma of the extremity secondary to chronic granulomatous inflammation in setting of sarcoidosis

Billero, Victoria; Jacobsen, Audrey A.; Miteva, Mariya; Wulkan, Adam; Marasca, Claudio; Romanelli, Paolo

doi:10.1111/cup.12988

Cited by 2 publications

(7 citation statements)

References 10 publications

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“…A sparse perivascular infiltrate consisting of lymphocytes and plasma cells, which are usually monotypic, is also visible in cutaneous AL amyloidoma [3,[17][18][19]. Lesions are indistinguishable from cutaneous nodular deposits in systemic AL amyloidosis [16]. These features were also present in both of our cases, although monotypic expression of immunoglobulin light chains on plasma cells was absent in case 2.…”

Section: Discussionsupporting

confidence: 52%

“…Histopathological features of the nodules of both of our patients were also similar to those observed in cutaneous amyloidomas. Histopathology of cutaneous amyloidoma shows a nodular deposit of eosinophilic material in the dermis and/or subcutaneous tissue staining with Congo red and showing apple-green birefringence under polarized light and corresponds to the amyloid deposits [16,17]. Tissue architecture is usually preserved [18], but it can also be replaced by the tumoral deposits of amyloid [16].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, long-term follow-up is recommended [14,15,17,21]. There is also a well-documented association between cutaneous AL amyloidoma and autoimmune diseases, especially Sjögren syndrome and systemic sclerosis, but also primary biliary cirrhosis, systemic lupus erythematous, and rheumatoid arthritis [15][16][17]20]. The continuous stimulation of the immune system in these conditions probably plays a role in the cutaneous plasma cell dysregulation associated with amyloidoma [14,17].…”

Section: Discussionmentioning

confidence: 99%

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Nail Amyloidoma: Two Case Reports of a New Entity

Bonito¹,

Kolivras²,

Saß³

et al. 2023

Skin Appendage Disord

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Introduction: Amyloidosis is a group of diseases characterized by extracellular deposits of abnormal insoluble proteins in different tissues. Amyloidoma is a localized tumoral deposit of amyloid in the absence of systemic amyloidosis, and it has been described in different anatomic sites. We report two cases of amyloidoma in the nail unit and provide insights into this recently described entity. Case Presentation: Both cases presented as an asymptomatic, slowly growing nodule underneath the distal nail bed of a toe with associated onycholysis. Histopathology was characterized in both patients by the presence of deposits of Congo red-positive, homogeneous, amorphous, and eosinophilic material within the dermis and subcutaneous tissue admixed with aggregates of plasma cells. In both cases, an extensive workup excluded systemic amyloidosis. Treatment was based on local excision, and no local recurrence or progression to systemic amyloidosis was observed at 1 year of follow-up. Conclusion: These are the first reports of amyloidomas of the nail unit. The clinical and histopathological presentations parallel those of an amyloidoma affecting the skin. Local excision seems to be an efficient treatment modality, but long-term follow-up is warranted in order to exclude recurrence, an associated marginal B-cell lymphoma, or progression to systemic amyloid L amyloidosis.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nail Amyloidoma: Two Case Reports of a New Entity

Bonito¹,

Kolivras²,

Saß³

et al. 2023

Skin Appendage Disord

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“…13 by combined PMI and pathological examination. Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities . There have been only a handful of case reports since 1998.…”

Section: Discussionmentioning

confidence: 99%

“…Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities. [30][31][32] There have been only a handful of case reports since 1998. We were able to see an interesting case by doing a pathological analysis using PMI of cadavers for anatomical dissection.…”

Section: Discussionmentioning

confidence: 99%

Pathological analysis of cadavers for educational dissection by using postmortem imaging

Noriki

Iino

Kinoshita

et al. 2019

Pathology International

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This study was performed primarily to clarify whether pathological analysis of cadavers for anatomical dissection is possible using postmortem imaging (PMI), and whether this is worthwhile. A total of 33 cadavers that underwent systematic anatomical dissection at our medical school also underwent PMI. Fixative solution was injected into the corpus 3–4 days after death. PMI was then performed using an 8‐slice multi‐detector CT scanner 3 months before dissection. Before dissection, a conference was held to discuss the findings of the PMI. First, two radiologists read the postmortem images without any medical information and deduced the immediate cause of death. Then, the anatomy instructor revealed the medical information available. Based on this information, the radiologist, anatomy instructor, and pathologists suggested candidate sampling sites for pathological examination. On the last day of the dissection period, the pathologists resected the sample tissues and processed them for pathological examination. In 12 of 33 cases, the presumed causes of death could be determined based on PMI alone, and revision of the cause of death described in the death certificate was considered in five (15.2%) cases, based on PMI and pathological analysis. This article presents a novel method of pathological analysis of cadavers for anatomical dissection using PMI without disturbing the anatomy education of medical students.

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Nodular cutaneous amyloidoma of the extremity secondary to chronic granulomatous inflammation in setting of sarcoidosis

Cited by 2 publications

References 10 publications

Nail Amyloidoma: Two Case Reports of a New Entity

Nail Amyloidoma: Two Case Reports of a New Entity

Pathological analysis of cadavers for educational dissection by using postmortem imaging

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