Markedly increased incidence of critical illness in adults with Type 1 diabetes

Abstract

Compared with the general population, the risk of intensive care unit admission was higher in adults with paediatric-onset Type 1 diabetes, and mortality after admission was also higher.

Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1

“…The above findings underscore the need to further investigate the treatment of the metabolic imbalance in DMT1 patients admitted to the ICU. In contrast to the general population adults with DMT1 have a higher admission and increased mortality in the ICU (62). Furthermore, the unexpected findings by Liou et al ( 63) that a higher mortality rate after moderate to serious trauma is associated with DMT1 but not with DMT2 suggests a need to taper patient care specifically to the DMT1 trauma patients: early ICU admission, rapid hyperglycemia and related insulin therapy especially after moderate to severe trauma in an effort to increase survival (63).…”

Nanotechnology's application in Type 1 diabetes

“…But, generally, the estimated number of children and adolescents with T1D continues to increase compared to the eighth edition IDF Diabetes Atlas (Patterson et al, 2019). And due to the improvement of diagnostic methods, more and more adults are diagnosed with T1D, and they also have higher annual and cumulative rates of critical illness (Marrie et al, 2017;Thomas et al, 2018).Regarding the pathogenesis of T1D, a conceptual model developed by George Eisenbarth in 1984 is now commonly used, but with the in-depth study of T1D, the scientists (Atkinson et al, 2014) made some modifications based on the George Eisenbat model ( Figure 2). In the development of T1D, heterogeneity exists at every stage and complex interactions between environmental factors, metabolism, the immune system, the genome, and the microbiome may affect the progress of T1D (DiMeglio, Evans-Molina, & Oram, 2018).…”

Management of Type 1 diabetes should be different from Type 2 diabetes at hospital admission

“…Med. Inpatient mortality is higher in patients with Type 1 diabetes [3]. There are certain differences in the pathophysiology of the two types of diabetes that need to be considered during diabetes care at hospitals.…”

“…Patients with Type 1 diabetes have higher glucose variability than those with Type 2 diabetes during the hospital stay [2]. Inpatient mortality is higher in patients with Type 1 diabetes [3]. Patients with Type 1 diabetes require insulin to prevent ketosis, despite being able to eat [4].…”