Guideline-concordant Care Improves Overall Survival for Locally Advanced Non–Small-cell Lung Carcinoma Patients: A National Cancer Database Analysis

Ahmed, Hiba; Liu, Yuan; OʼConnell, Kelli; Ahmed, M.; Cassidy, Richard J.; Gillespie, Theresa W.; Patel, Pretesh; Pillai, Rathi N.; Behera, Madhusmita; Steuer, Conor E.; Owonikoko, Taofeek K.; Ramalingam, Suresh S.; Higgins, Kristin

doi:10.1016/j.cllc.2017.04.009

Cited by 30 publications

(25 citation statements)

References 33 publications

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“…3 ). BRAF and ROS-1 were investigated according to the guidelines, however; the gene expression was negative for both [ 6 ]. Three days after the second nivolumab administration the patient started to have severe clinical findings of peeling in both upper and lower limbs ( Fig.…”

Section: Case Presentationmentioning

confidence: 99%

Psoriatic arthritis due to nivolumab administration a case report and review of the literature

Sapalidis

Kosmidis

Michalopoulos

et al. 2018

Respiratory Medicine Case Reports

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Nowadays we have novel equipment for lung cancer diagnosis, however; due to lack of symptoms, lung cancer is still diagnosed at a late stage. Currently we have the following therapies for non-small cell lung cancer: a) non-specific cytotoxic agents, b) targeted therapies and c) immunotherapy. Each therapy has its own advantages and adverse effects. In the current case we will present a rare case of psoriacic arthritis that was presented after two cycles of nivolumab administration and we will also present a review of the literature.

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Section: Case Presentationmentioning

confidence: 99%

Psoriatic arthritis due to nivolumab administration a case report and review of the literature

Sapalidis

Kosmidis

Michalopoulos

et al. 2018

Respiratory Medicine Case Reports

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“…2,3 With the improved diag-nostic capabilities of modern imaging and advanced guidelines, the incidence of early stage lung cancer will become more prevalent and this trend will only become more extreme. [4][5][6] If lung cancer screening is introduced, then this effect will be compounded. 7 Respiratory complications postoperatively have traditionally been the main causative factor of mortality in lung cancer surgery.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Observational Study into the Early Causes of Death Following Surgery for NSCLC

Smelt

Martin

Al-Sahaf

et al. 2018

Thorac Cardiovasc Surg

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Introduction Respiratory failure has historically been the major cause of mortality after elective lung resections. With improved intubation using fiber-optic scopes, better preoperative respiratory risk assessment, more advanced anesthetic single lung ventilation, and minimally invasive surgical technique, this may have changed. Our objective was to assess the main causes of mortality over the past 10 years in patients undergoing elective lung surgery in a major UK center. Materials and Methods A retrospective unit data search was made for all deaths during the 10-year period between January 2007 and December 2016 inclusive. All inpatient deaths within 30 days of an elective anatomical lung resection for lung malignancies were included. Results Three-thousand three-hundred sixteen lung resections for malignancy were performed in the 10-year period. There were 44 (1.3%) deaths during this period, 27 (61.4%) after open lobectomies, 8 (18.2%) after video-assisted thoracoscopic surgery lobectomies, 5 (11.4%) after sleeve lobectomies, and 4 (9%) after pneumonectomies. Causes of death included 24 (54.5%) respiratory failure, 10 (22.7%) ischemic bowel, 4 (9%) coronary events, 2 (4.5%) strokes, 2 (4.5%) on table hemorrhage, 1 (2.3%) massive pulmonary embolus, and 1 (2.3%) postoperative hemorrhage. Conclusion Although respiratory failure is still a major cause of mortality in the postoperative patient, bowel ischemia has been found to be the second greatest cause of death. This study highlights the need to identify those at risk of this fatal complication during preoperative assessment and their postoperative management.

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“…1 Furthermore, the increasing longevity of the Western population means patients with a more advanced age are being diagnosed with resectable disease and referred for surgery. 2 Improvements in imaging and diagnostic capabilities and with the possibility of lung cancer staging, this trend is likely to develop further. 3 There is a paucity of evidence to guide surgical decision making in the elderly, particularly in thoracic surgery, due to underrepresentation in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Elective Lung Resections in the Elderly: Where Do We Draw the Line?

Smelt

Lovejoy

Thakker

et al. 2020

Thorac Cardiovasc Surg

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Introduction The increasing longevity of the Western population means patients with a more advanced age are being diagnosed with resectable disease. With improvements in imaging and diagnostic capabilities, this trend is likely to develop further. As a unit operating on a higher proportion of older patients and with limited literature regarding the population of older than 85 years, we retrospectively compared the outcomes of patients older than 85 years in our unit treated with elective lung resection for non-small cell lung cancer (NSCLC) with those between the age of 80 and 84 years inclusive. Methods All patients who underwent elective lung cancer resection between the years 2012 and 2015 were identified from the National Thoracic Surgical Database. Results A total of 701 elective lung resections were performed during this time frame; 76 patients between the ages of 80 and 84 years and 18 patients older than 85 years. The follow-up period was 3 to 7 years. There was a significant increase in the Thoracic Surgery Scoring System (2.04; 2.96%, p = 0.0015) and a significant reduction in the transfer factor (94.7; 69.5%, p = 0.0001) between the younger and older groups. There were three (3.9%) in-hospital deaths in the 80 to 84 years age group and no in-hospital deaths in the 85 years and older age group. Conclusion This study demonstrates that surgery for early NSCLC can be safely performed in 85 years and older population. This is a higher risk population and parenchymal-sparing procedures should be considered.

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Guideline-concordant Care Improves Overall Survival for Locally Advanced Non–Small-cell Lung Carcinoma Patients: A National Cancer Database Analysis

Cited by 30 publications

References 33 publications

Psoriatic arthritis due to nivolumab administration a case report and review of the literature

Psoriatic arthritis due to nivolumab administration a case report and review of the literature

Retrospective Observational Study into the Early Causes of Death Following Surgery for NSCLC

Elective Lung Resections in the Elderly: Where Do We Draw the Line?

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