Physical function and 25-hydroxyvitamin D in dialysis patients – lessons learned from the Slovenian DIAGIB study

Pajek, Maja BuÄar; Äuk, Ivan; Mlinšek, Gregor; Osredkar, Joško; Pajek, Jernej

doi:10.5414/cnp88fx12

Cited by 3 publications

(2 citation statements)

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“…Among the healthy adult population, three research clusters ( 20 , 21 , 22 ) were composed of healthy individuals, one cluster of presumably healthy individuals ( 23 ) (as the data collection was carried out retrospectively in a laboratory with self-pay service), and another three research clusters ( 24 , 25 , 26 , 27 ) of healthy individuals from control groups. A nationally representative study sample (adults 18-64 years) was only used in one study ( 20 ), which was conducted in 2017-2018, and covered all calendar seasons.…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen research clusters included data from adult patient populations: five research clusters included chronic kidney disease patients ( 24 , 25 , 45 , 46 , 47 , 48 , 49 , 50 ), three research clusters included type 2 diabetics ( 26 , 51 , 52 ), two clusters included patients with bone metabolism disorder or trauma ( 53 , 54 ), two clusters included mixed data from University Medical Centre Ljubljana laboratories ( 55 , 56 ), and single-cluster studies included patients after heart transplant ( 57 ), HIV patients ( 58 ), chronic intestinal failure patients on long-term home parenteral nutrition ( 59 ), and patients treated with antiepileptic drugs ( 27 ).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of vitamin D status and dietary intake in various Slovenian populations

Hribar

Benedik

Gregorič

et al. 2022

Slovenian Journal of Public Health

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Aim Vitamin D (VitD) is involved in calcium and phosphate homeostasis, bone health, and normal functioning of the immune system. VitD status is monitored using serum 25-hydroxy-vitamin D (25(OH)D) as a biomarker. Serum 25(OH)D concentrations below 30 nmol/L indicate VitD deficiency and below 50 nmol/L indicate insufficiency. VitD can be synthesised endogenously in human skin when exposed to ultraviolet B (UVB) radiation. In the absence of sufficient UVB-light exposure, VitD intake becomes the main source of VitD, with a recommended daily intake of 20 μg. The aim of this study was to conduct a review and meta-analysis on the abovementioned topics, focusing on scientific studies in various Slovenian populations. Methods We conducted a systematic review and meta-analysis of published scientific papers, academic theses, or conference contributions reporting serum 25(OH)D status and VitD intake across various Slovenian populations. A search was carried out using Web of Science, Scopus, Medline, and the Slovenian library database. Results We identified 43 pertinent studies that addressed 25(OH)D status and 16 that addressed VitD intake. Serum 25(OH)D status was generally low across all populations, and notable seasonal variability was observed. VitD intakes were below 5 μg in all studies. Conclusions A general observation is that various population groups across Slovenia are at high risk of vitamin D insufficiency and deficiency, particularly during wintertime. Regarding vitamin D intake, all included studies reported daily intakes below the recommended level. We also identified key research gaps that need to be addressed to support further public health decision-making.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A systematic review of vitamin D status and dietary intake in various Slovenian populations

Hribar

Benedik

Gregorič

et al. 2022

Slovenian Journal of Public Health

View full text Add to dashboard Cite

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Association between Vitamin D Level and Muscle Strength in Patients Undergoing Hemodialysis

Kang

Young

Cho

et al. 2020

Kidney Blood Press Res

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Introduction: Identification of the risk factors and treatment of the decrease in muscle mass or strength are important to improve the prognosis of patients undergoing hemodialysis (HD). Previous studies have investigated the association between vitamin D level and muscle mass or strength in patients undergoing HD. However, there are conflicting results regarding this association. Objective: To evaluate the association between vitamin D level and muscle mass indices, strength, or physical performance in patients undergoing HD. Methods: This study was performed in a tertiary medical center. We included patients undergoing HD aged ≥20 years. A total of 84 patients were enrolled. The patients were divided into tertiles based on the 25-hydroxy (25-OH) vitamin D level as follows: lowest tertile (Lowest T, n = 28), middle tertile (Middle T, n = 28), and highest tertile (Highest T, n = 28). We evaluated the association between the tertiles and clinical outcomes including nutritional status, muscle mass, muscle function, handgrip strength (HGS), physical performance, and health-related quality of life (HRQoL) scales. Results: There were no significant differences in the muscle mass indices and nutritional markers according to tertiles of 25-OH vitamin D level. However, 25-OH vitamin D level as a continuous variable or the tertile of 25-OH vitamin D level as a categorical variable was positively associated with HGS. Logistic and linear regression analyses showed a consis-

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Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

Chen

et al. 2022

BMC Nephrol

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Background Muscle dysfunction is prevalent in dialysis patients. Gait speed and handgrip strength are simple and reliable methods of assessing muscle function. Numerous observational studies have linked 25-hydroxy vitamin D[25(OH)D] status with gait speed and handgrip strength in populations without kidney diseases. This study aimed to evaluate the potential associations of 25(OH)D status with gait speed and handgrip strength in patients on hemodialysis. Methods In this observational cross-sectional study, demographic data, biological data, and dialysis parameters were collected. Gait speed and handgrip strength were measured. Multiple linear regression and logistic regression analysis were used to investigate the relationship of 25(OH)D status with gait speed and handgrip strength after adjusting for potential confounders. Results Overall, a total of 118 participants undergoing hemodialysis were included. Seventy-one (60.2%) participants were male. The median 25(OH)D status in participants was 11.58 (interquartile range: 8.51 to 15.41) ng/ml. When controlling for age, gender, dialysis vintage, and other confounders with a p-value < 0.15 in univariate analyses, 25(OH)D was significantly positively associated with gait speed (β = 0.16, 95% CI 0.05 to 0.28, p = 0.006) and handgrip strength (β = 3.83, 95% CI 1.09 to 6.56, p = 0.007). Conclusion Our study showed that 25(OH)D status seemed to be associated with gait speed and handgrip strength in patients on hemodialysis. However, these results were not robust. The relationships between 25(OH)D status and gait speed and handgrip should be further explored.

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Physical function and 25-hydroxyvitamin D in dialysis patients – lessons learned from the Slovenian DIAGIB study

Abstract: Serum 25-hydroxyvitamin D levels are significantly positively associated with submaximal aerobic physical performance and habitual activity level in dialysis patients. .

Cited by 3 publications

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A systematic review of vitamin D status and dietary intake in various Slovenian populations

A systematic review of vitamin D status and dietary intake in various Slovenian populations

Association between Vitamin D Level and Muscle Strength in Patients Undergoing Hemodialysis

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

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Physical function and 25-hydroxyvitamin D in dialysis patients – lessons learned from the Slovenian DIAGIB study

Abstract: Serum 25-hydroxyvitamin D levels are significantly positively associated with submaximal aerobic physical performance and habitual activity level in dialysis patients. .

Cited by 3 publications

References 0 publications

A systematic review of vitamin D status and dietary intake in various Slovenian populations

A systematic review of vitamin D status and dietary intake in various Slovenian populations

Association between Vitamin D Level and Muscle Strength in Patients Undergoing Hemodialysis

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

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Abstract: Serum 25-hydroxyvitamin D levels are significantly positively associated with submaximal aerobic physical performance and habitual activity level in dialysis patients. .