Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications

Senfter, Daniel; Erkan, Erdoğan Pekcan; Özer, Erdener; Jungwirth, Gerhard; Madlener, Sibylle; Kool, Marcel; Ströbel, Thomas; Saydam, Nurten; Saydam, Okay

doi:10.1002/pbc.26670

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…MCM10 is a replication initiation factor that plays functions together with the MCM2‐7 helicase and the DNA polymerase alpha/primase complex . Previous studies have observed MCM10 is overexpressed in different types of human cancers, such as medulloblastoma, cervical cancer, and esophageal cancer . Furthermore, Li et al demonstrated that MCM2 and MCM10 were the two most significantly upregulated genes in urothelial carcinoma progression among the MCM gene family .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies show MCM10 is often dysregulated under pathological conditions . Genetic amplification and/or overexpression of MCM10 were also observed in different types of human cancers . For instance, Cheng et al found a series of replicative helicase proteins, such as MCM10, MCM2, MCM4, MCM5, and MCM6 were overexpressed in cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer

Cui

Ning

et al. 2018

The Prostate

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BackgroundProstate cancer (PCa) is one of the most malignant tumors of the male urogenital system. There is an urgent need to identify novel biomarkers for PCa.MethodsIn this study, we evaluated the expression levels of MCM10 in prostate cancer by analyzing public datasets (including The Cancer Genome Atlas and GSE21032). Furthermore, loss of function assays was performed to evaluate the effects of MCM10 on cell proliferation, apoptosis, and colony formation. Furthermore, we performed microarray and bioinformatics analyses to explore the potential mechanisms of MCM10.ResultsIn the present study, we for the first time revealed MCM10 was significantly upregulated in PCa. Moreover, we found increased MCM10 expression was significantly associated with advanced clinical stage and high Gleason score PCa. Kaplan‐Meier analysis demonstrated higher MCM10 expression was associated with a poorer patient prognosis in PCa. Furthermore, loss of function assays showed that MCM10 knockdown inhibited cell proliferation and colony formation, but promoted cell apoptosis. Additionally, we performed microarray and bioinformatics analysis and found MCM10 regulated PCa progression by regulating a series of biological processes including cancer, cell death, and apoptosis.ConclusionsThese results suggest that MCM10 may be a potential diagnostic and therapeutic target for PCa.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer

Cui

Ning

et al. 2018

The Prostate

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“…MCM10 was increased in medulloblastoma, urothelial carcinomas, prostate cancer and breast cancer [41][42][43][44] and finally, AUNIP was overexpressed in various brain tumors [45]. Conversely, respective expression of the 6 selected genes was downregulated by the three treatments in this study.…”

Section: Gene Expression Changes Related To Cancer Progressionmentioning

confidence: 61%

Predictive early gene signature during mouse Bhas 42 cell transformation induced by synthetic amorphous silica nanoparticles

Kirsch

Dubois-Pot-Schneider

Fontana

et al. 2020

Chemico-Biological Interactions

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“…MCM10, along with CDC45-MCM2-7 complex, is a subtype of the MCM family relating to initiating DNA replication and regulating cell proliferation in late G1 or early S phase of cell cycle [16][17][18] . Accumulating studies have shown that MCM10 expression tended to be higher in a variety of malignancies [19][20][21][22][23] . Over-expression of MCM10 in some cancers had a close relationship with tumor progression and dismal clinical outcomes [19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Transcriptional Expression of Minichromosome Maintenance 10 as an Independent Negative Predictor of Survival in Hepatocellular Carcinoma

Chen¹,

Li²,

Chen³

et al. 2020

Preprint

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Background: The minichromosome maintenance protein 10 (MCM10) is a replication licensing factor that initiates eukaryotic genome replication by interacting with CDC45-MCM2-7 complex, thereby mediating cellular proliferation. Recent studies have found that MCM10 is involved in tumorigenesis and cancer development. However, research on the role of MCM10 in hepatocellular carcinoma (HCC) is scarce.Methods: In this study, the transcriptional expression, prognostic efficacy and function of MCM10 in HCC were explored through the public dadabases and bioinformatic tools, including ONCOMINE, Kaplan-Meier plotter, cBioPortal, TIMER and GEPIA. Statistical significance was inferred at a P-value < 0.05.Results: It was found that MCM10 expression was commonly overexpressed in cancer specimens compared to match normal tissues. Up-regulation of MCM10 gene in HCC had a close relationship with patients’ survival time. A higher level of MCM10 expression was correlated with shorter overall survival (OS) and progression-free survival (PFS) in HCC patients, especially at early stages (grade 2 or stage 1+2). MCM10 was also demonstrated to be an independent negative predictor of OS and disease-free survival (DFS) in patients with HCC by multivariate Cox regression. Additionally, according to the levels of marker genes for different immune cells in HCC, MCM10 expression was markedly positively correlated with the numbers of tumor-infiltrating B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells, indicating its potential immunogenic role in HCC. Conclusions: MCM10 could be exploited as a potential independent prognostic indicator as well as therapeutic target for HCC patients.

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Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications

Abstract: Taken together, our study reveals that the pre-RC is dysregulated in MB. In addition, MCM10, a member of this complex, is significantly overexpressed in MB and is required for tumor cell proliferation.

Cited by 11 publications

References 35 publications

Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer

Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer

Predictive early gene signature during mouse Bhas 42 cell transformation induced by synthetic amorphous silica nanoparticles

Transcriptional Expression of Minichromosome Maintenance 10 as an Independent Negative Predictor of Survival in Hepatocellular Carcinoma

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