How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ?

Abernethy, Julia; Johnson, Alan P.; Hope, Russell

doi:10.1099/jmm.0.000489

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Hamdy et al also demonstrated that foci such as OM (31%), catheter-related infection (22%), SSTI (16%) and pneumonia (9%) are predominant 31 in a cohort of children with bacteremia caused by MRSA. Abernethy et al, in turn, reported that most bacteremia cases caused by MSSA originated from SSTI 33 ; this is similar to what has been reported in this study.…”

Section: Discussionsupporting

confidence: 91%

“… 31 In children, community-based S. aureus bacteremia is more frequent and is associated with concomitant foci of infection 30 , 32 while healthcare-associated bacteremia is more commonly observed in neonates under the age of one and usually related to intravascular devices. 33 Significant risk factors were found based on the origin of secondary bacteremia; osteoarticular and pulmonary foci are at increased risk of secondary bacteremia due to MRSA. Hamdy et al also demonstrated that foci such as OM (31%), catheter-related infection (22%), SSTI (16%) and pneumonia (9%) are predominant 31 in a cohort of children with bacteremia caused by MRSA.…”

Section: Discussionmentioning

confidence: 99%

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Differences Between Methicillin-susceptible Versus Methicillin-resistant Staphylococcus aureus Infections in Pediatrics

Camacho-Cruz

Gutiérrez

Brand-López

et al. 2021

Pediatric Infectious Disease Journal

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Background: The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) has changed in recent years. The present article is intended to establish differences between clinical, laboratory and imaging findings and outcomes of MSSA and MRSA infections, as well as among subgroups of infection such as skin and soft tissue infection, osteoarticular, bacteremia or pneumonia in a pediatric population from Bogota, Colombia. Methods: Retrospective cohort study using clinical records of patients under 18 years of age treated at the participating centers in Bogota, Colombia, between 2014 and 2018. The first positive S. aureus culture was studied. MSSA and MRSA were compared. The χ 2 test, Fisher exact test, and Kruskal-Wallis test were calculated, and the statistical significance was presented using the difference and its 95% CI. Results: Five hundred fifty-one patients were included; 211 (38%) corresponded to MRSA and 340 (62%) to MSSA for a total of 703 cultures. A significantly higher probability of having an MSSA infection than MRSA was found in patients with previous heart disease (3.3% vs. 0.5%), neurologic disease (5.9% vs. 2.5%), recent major surgeries (11% vs. 5%) or who has an implanted device (11% vs. 4%). In contrast, in severe MRSA infections (bacteremia, osteoarticular infections and pneumonia), a higher rate of complications was seen (admission to the pediatric intensive care unit, mechanical ventilation and vasoactive support), and in osteoarticular MRSA, more than 1 surgery per case was seen (89% vs. 61%). Laboratory results and mortality were similar. Conclusions: MRSA was associated with a more severe course in bacteremia, osteoarticular infections and pneumonia. Some classical risk factors associated with MRSA infections were found to be related to MSSA. In general, with the exception of skin and soft tissue infection, there was an increased risk of pediatric intensive care unit admission and mechanical and inotropic support with MRSA in a pediatric population.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Differences Between Methicillin-susceptible Versus Methicillin-resistant Staphylococcus aureus Infections in Pediatrics

Camacho-Cruz

Gutiérrez

Brand-López

et al. 2021

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

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Intermittent point prevalence surveys on healthcare-associated infections, 2011 and 2016, in England: what are the surveillance and intervention priorities?

Henderson,

Saei,

Freeman

et al. 2023

Journal of Hospital Infection

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Staphylococcus aureusbacteraemia and endocarditis – epidemiology and outcome: a review

Ásgeirsson

Thalme

Weiland

2017

Infectious Diseases

100

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The reported incidence of SAB in Western countries is 16-41/100,000 person-years. Increasing incidence has been observed in many regions, in Iceland by 27% during 1995-2008. The increase is believed to depend on changes in population risk factors and possibly better and more frequent utilization of diagnostic procedures. S. aureus is now the leading causes of infective endocarditis (IE) in many regions of the world. It accounts for 15-40% of all IE cases, and the majority of cases in people who inject drugs (PWID). Recently, the incidence of SAE in PWID in Stockholm, Sweden, was found to be 2.5/1000 person-years, with an in-hospital mortality of 2.5% in PWID as compared to 15% in non-drug users. The 30-day mortality associated with SAB amounts to 15-25% among adults in Western countries, but is lower in children (0-9%). Mortality associated with SAE is high (generally 20-30% in-hospital mortality), and symptomatic cerebral embolizations are common (12-35%). The 1-year mortality reported after SAB and SAE is 19-62% and reflects deaths from underlying diseases and complications caused by the infection. In a subset of SAE cases, valvular heart surgery is needed (15-45%), but active intravenous drug use seems to be a reason to refrain from surgery. Despite its importance, there are insufficient data on the optimal management of SAB and SAE, especially on the required duration of antibiotic therapy. Conclusions: The epidemiology of SAB and SAE has been changing in the past decades. They still carry a substantial morbidity and mortality. Intensified studies on treatment are warranted for improving patient outcome.

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How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ?

Cited by 3 publications

References 12 publications

Differences Between Methicillin-susceptible Versus Methicillin-resistant Staphylococcus aureus Infections in Pediatrics

Differences Between Methicillin-susceptible Versus Methicillin-resistant Staphylococcus aureus Infections in Pediatrics

Intermittent point prevalence surveys on healthcare-associated infections, 2011 and 2016, in England: what are the surveillance and intervention priorities?

Staphylococcus aureusbacteraemia and endocarditis – epidemiology and outcome: a review

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