Associations between serum 25(OH)D concentrations and prevalent asthma among children living in communities with differing levels of urbanization: a cross-sectional study

Pollard, Suzanne L.; Lima, John J.; Romero, Karina; Tarazona-Meza, Carla; Mougey, Edward H.; Tomaino, Katherine; Malpartida-Guzmán, Gary; Hansel, Nadia N.; Checkley, William

doi:10.1186/s40733-017-0033-2

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Based on the correlation test shows that ACT Score and Vitamin D have a positive but not statistically significant (p = 0.195, r = 0.209). In line with research which was conducted by Pollard et al 24 who found no significance between 25 (OH) D levels with ACT scores and improvement in lung function. The results of a recent metaanalysis from Cochrane showed that vitamin D supplementation significantly reduced the risk of asthma exacerbations requiring oral corticosteroids (ratio of 0.63, 95% CI: 0.45-0.88).…”

Section: Discussionsupporting

confidence: 88%

The correlation of 25-Hydroxyvitamin D (25-(OH)D) to IgE level, eosinophil, and Asthma Control Test (ACT) score in asthma patients

Olivianto

Habibi

Udin

et al. 2022

PEDSCIJ

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Background: Asthma is a heterogenouse disease with chronic inflammation which is characterized by hyperreactivity and obstruction of respiratory tract. Many hypothesis of asthma were related with nutrition, such as vitamin D status. Vitamin D is a precursor of steroid hormone that has immunomodulator effect but the relationship of asthma and vitamin D still controversial. This study aims to find the relationship of vitamin D (25-(OH)D) with level of IgE, Eosinophils, and asthma control test (ACT) in mild to moderate pediatric asthmatic patient. Method: An observational analytic study with cross-sectional approach has been conducted among 40 pediatric asthmatic patients by consecutive sampling technique. Data regarding gender, age, vitamin D status, the levels of 25-(OH)D, IgE, Eosinophil, and ACT score were assessed in this study. Correlation analysis test was used as statistical analysis using SPSS version 20 for Windows.Result: Most of respondents were male (70.0%), 5-7 years of age range (52.5%), and insufficient of vitamin D (20-30 ng/ml) (45.0%). The recent study suggests a significant negative relationship between serum 25 (OH) D levels with total immunolobulin E levels (p=0.002; r=-0.476) and eosinophils (p = 0.002; r=-0.479). However, the 25-(OH)D level did not show a significant relationship with the ACT score (p = 0.195; r=0.209).Conclusion: Negative relationship was found between total serum 25(OH)D, total immunoglobulin E, and eosinophils in children with asthma. Moreover, 25(OH)D was not related to ACT score in children with asthma.

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Section: Discussionsupporting

confidence: 88%

The correlation of 25-Hydroxyvitamin D (25-(OH)D) to IgE level, eosinophil, and Asthma Control Test (ACT) score in asthma patients

Olivianto

Habibi

Udin

et al. 2022

PEDSCIJ

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“…The publication of the parent study, GASP, is currently under review. However, two separate ancillary studies from the parent study have already been published 18,19 .…”

Section: Methodsmentioning

confidence: 99%

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Nicholson

Pollard

Lima

et al. 2017

Respiratory Medicine

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Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR=1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

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“…Based on the inclusion and exclusion criteria, a total of 35 studies were finally included in our meta-analysis. Among them, 24 studies were analyzing the association between 2, 5-OHD level and the occurrence of asthma (Alyasin et al, 2011;Awasthi & Vikram, 2014;Bai & Dai, 2018;Bener et al, 2014;Chinellato et al, 2011;Esfandiar et al, 2016;Han et al, 2017;Han et al, 2018;Hatami et al, 2014;Havan et al, 2017;Hennessy et al, 2018;Kang et al, 2018;Khan et al, 2014;Kim et al, 2017;Menon et al, 2012;Mirzakhani et al, 2018;Munkhbayarlakh et al, 2019;Omole et al, 2018;Ozkars et al, 2019;Ozturk Thomas et al, 2019;Pollard et al, 2017;Reinehr et al, 2018;Thorsteinsdottir et al, 2020;Wawrzyniak et al, 2017), and 12 studies were evaluating the effect of vitamin D supplement in treating asthma (Bar Yoseph et al, 2015;Baris et al, 2014;Jensen et al, 2016;Kang et al, 2018;C. P. Kerley et al, 2016;Litonjua et al, 2020;Paweł Majak et al, 2011;P.…”

Section: Literature Selectionmentioning

confidence: 99%

Vitamin D and asthma occurrence in children: A systematic review and meta-analysis

Wang

Ying

Zhang

et al. 2022

Journal of Pediatric Nursing

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Associations between serum 25(OH)D concentrations and prevalent asthma among children living in communities with differing levels of urbanization: a cross-sectional study

Cited by 8 publications

References 32 publications

The correlation of 25-Hydroxyvitamin D (25-(OH)D) to IgE level, eosinophil, and Asthma Control Test (ACT) score in asthma patients

The correlation of 25-Hydroxyvitamin D (25-(OH)D) to IgE level, eosinophil, and Asthma Control Test (ACT) score in asthma patients

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Vitamin D and asthma occurrence in children: A systematic review and meta-analysis

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