Sesquiterpene glucosides from Shenzhou honey peach fruit showed the anti-aging activity in the evaluation system using yeasts

Abstract

One new (1, SZMT01) and one known (2) anti-aging substances were isolated from Shenzhou honey peach fruit. Their structures were elucidated by spectroscopic methods and chemical derivatization, and the result reveals that these two compounds are sesquiterpene glucosides. SZMT01 possesses a new glycosylation with an ester linkage at one terminal in an acyclic sesquiterpenoid which is the end of a double bond at another terminal. Both compounds extend the replicative lifespan of K6001 yeast strain at doses of 7.5 and 25 μM. Then, to understand the action mechanism involved, we performed an anti-oxidative experiment on SZMT01. The result revealed that treatment with SZMT01 increased the survival rate of yeast under oxidative stress. Moreover, the lifespans of sod1 and sod2 mutant yeast strains with a K6001 background were not affected by SZMT01. These results demonstrate that anti-oxidative stress performs important roles in anti-aging effects of SZMT01.

Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress

“…Natural products are important sources of drugs to reduce or prevent oxidative stresses in humans. In our previous studies, 19 molecules were isolated from natural products which were able to extend the replicative lifespan of yeast via antioxidative stress [20][21][22][23][24][25]. Therefore, searching for effective molecules with antioxidative stress potential should be considered an important strategy to treat aging and neurodegenerative disorders.…”

“…A unique characteristic of K6001 is that only mother cells can produce daughter cells in a glucose medium but not in a galactose medium [26]. In our previous study, K6001, which is a yeast mutant strain, was used as a bioassay system to evaluate the antiaging activity of natural products [20][21][22][23][24][25]. Furthermore, the PC12 cell line, which was derived from rat pheochromocytoma cells, is one of the useful models for studying the nervous system at the cellular level [27].…”

Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential

“…[35] Sesquiterpenes and their derivatives were reported to possess broad antioxidant, anti-inflammatory, and antiaging activities. [36,37] Caryophyllene, α-cubebene, germacrene, and copaene found in C.…”

“…Sesquiterpenes and their derivatives were reported to possess broad antioxidant, anti‐inflammatory, and antiaging activities. [ 36,37 ] Caryophyllene, α ‐cubebene, germacrene, and copaene found in C. paradisi and C. deliciosa were reported to exhibit moderate antiaging activity toward enzymes, such as tyrosinase. [ 38,39 ] Furthermore, phellandrene inhibited intracellular H 2 O 2 , hydroxyl radical generations, and elastase activity.…”

Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review

“…Besides, treatment with sesquiterpene glucosides could not affect the RLSs of SOD mutant yeast strains with a K6001 background, indicating that the anti-oxidative stress response performs important roles in anti-aging effects of sesquiterpene glucosides. 86…”