Synthesis of Magnetic‐Nanoparticle/Ansamitocin Conjugates—Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo

Seidel, Katja; Balakrishnan, Asha; Janko, Christina; Komoll, Ronja-Melinda; Wang, Liangliang; Kirschning, Andreas; Ott, Michael

doi:10.1002/chem.201701491

Cited by 14 publications

(12 citation statements)

References 28 publications

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“… Heat-induced release of ansamitocin (chemo + MHT), sacrifice day ~10,A follow-up treatment would be necessary to sustain inhibitory effect on tumor growth. [ 85 ] Human hepatocellular carcinoma SMMC-7721 (1 × 10 6 ) NS (nude mice) ~450 mm 3 PLGA NA NR (50 μL of 20% Fe) IT 0 626 NR (28.6 A) ~2 1 52 Tumor ablation and elimination 5 days after MHT observed in synergy with DOX release upon heating. MHT alone produces tumor ablation with residual growth 8 days after treatment.…”

Section: Table A1mentioning

confidence: 99%

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

2020

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Magnetic hyperthermia (MHT) is being investigated as a cancer treatment since the 1950s. Recent advancements in the field of nanotechnology have resulted in a notable increase in the number of MHT studies. Most of these studies explore MHT as a stand-alone treatment or as an adjuvant therapy in a preclinical context. However, despite all the scientific effort, only a minority of the MHT-devoted nanomaterials and approaches made it to clinical context. The outcome of an MHT experiment is largely influenced by a number of variables that should be considered when setting up new MHT studies. This review highlights and discusses the main parameters affecting the outcome of preclinical MHT, aiming to provide adequate assistance in the design of new, more efficient MHT studies.

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Section: Table A1mentioning

confidence: 99%

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

2020

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“…In vivo experiments reflected that, despite the fact that tumor temperatures increased up to 43 °C, the treatment efficiency in the group of mice with the nanomaterial and the drug was enough to provoke the inhibition of tumor growth in comparison with the control groups. Anatomopatologic studies revealed that tumor cells expressed Ki67, a typical marker for cell proliferation, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining revealed an increase in apoptosis …”

Section: Joining Together Hot Spots and Drug Release: Synergic Effectmentioning

confidence: 99%

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

et al. 2018

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that cancer cells are more sensitive to heat than normal ones [2,3] and the huge advances in the field of nanotechnology have given researchers new tools to design new, more sophisticated, and more specific heat treatments. Here, we focus on several electromagnetic responsive nanomaterials capable of acting as thermoseeds, which can induce changes in their environment through heating processes. We will pay special attention to the heat generation and its applications, as well as the biological response to the temperature rise at the nanoscale. Two sorts of nanomaterials that allow these new thermaltreatment approaches are especially attractive, depending on the radiation used to provoke the nanomaterial's response. Answering to the type of radiation used to carry out hyperthermia treatments, the nanomaterial characteristics required are completely different. The first application is typically called magnetic hyperthermia (MH), which uses alternating magnetic fields (AMFs); which are electromagnetic (EM) waves in the range of the EM spectrum that corresponds to radiofrequency (RF). The second, typically called optical hyperthermia, uses radiation in the part of the EM spectrum that corresponds to the near-infrared (NIR).The first approaches in hyperthermia treatments in both optical and magnetic stimuli mediated by nanoparticles were focused on the idea of using high doses of nanomaterials to produce enough heat to kill cancer cells by a global temperature increase. Researchers working in this field have to face several drawbacks, as the difficulty of localizing a high concentration of material in the target tissue, inadequate animal models, inaccurate temperature measurement, or limitations of the source conditions that can be used for in vivo experiments make the temperature rise often insufficient. [4] First, it is important to consider that the half-life and tissue penetration of the nanocarrier does not depend on the nanoparticle nature but on the coatings developed to enhance their stability in the physiological environment. Therefore, besides the heating efficiency, the predominant factor in the choice of hyperthermia generation is restricted by the location of the cancer tissue. Both RF and NIR irradiation can be considered useful external and noninvasive stimuli, but the main difference between the two is the tissue penetration. While magnetic fields Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the use of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic-and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscal...

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“…The furan and maleimide Diels–Alder pair has also featured heavily in our own work, developed over a number of years in combination with new technology in the area of mutational biosynthesis (“mutasynthesis”) . Silica‐coated SPIONs were first functionalized with maleimide, then loaded with antiproliferative furan‐ligated ansamitocin derivatives by heating to 62 °C in acetonitrile for three days ( Scheme ).…”

Section: Thermal Cleavage Of Temperature‐sensitive Covalent Linkersmentioning

confidence: 99%

Externally Induced Drug Release Systems with Magnetic Nanoparticle Carriers: An Emerging Field in Nanomedicine

Norris

Seidel

Kirschning

2018

Advanced Therapeutics

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Core-shell nanoparticles that exhibit superparamagnetic properties and stability as colloidal suspensions have been widely employed for medical imaging, diagnosis, and targeted drug delivery. These materials are engineered for spatial guidance using an external magnetic field and are capable of transporting therapeutic payloads such as clinical drugs and protein structures. They can be tagged with fluorescent dyes and quantum dots as spectroscopic markers; and can generate an acute influx of heat when exposed to an alternating magnetic field. When these functions are used in combination, core-shell nanoparticles can operate in a multimodal fashion, on demand, using external and non-invasive stimuli. In this short review, selected examples of externally induced drug release systems with magnetic nanoparticle carriers are highlighted. This new and emerging field of nanomedicine has enormous potential to advance our therapeutic capabilities with a central concept of targeting, locating, and detonating diseased and cancerous tissues in vivo with precise ex vivo control.

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Synthesis of Magnetic‐Nanoparticle/Ansamitocin Conjugates—Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo

Cited by 14 publications

References 28 publications

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

Externally Induced Drug Release Systems with Magnetic Nanoparticle Carriers: An Emerging Field in Nanomedicine

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