Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort

Torchin, Héloïse; Lorthe, Elsa; Goffinet, François; Kayem, Gilles; Subtil, D.; Truffert, Patrick; Devisme, Louise; Benhammou, Valérie; Jarreau, Pierre‐Henri; Ancel, Pierre‐Yves

doi:10.1016/j.jpeds.2017.05.019

Cited by 32 publications

(22 citation statements)

References 39 publications

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“…However, in our study, RDS and BPD were found to be similar among the groups. A recent study has supported our results (40). Another study reported that funisitis increases the risk of BPD (41).…”

Section: Discussionsupporting

confidence: 91%

“…That means that RDS and BPD not only result from CA but they might also arise from the adverse effects of preterm delivery. Many factors (multiple hits hypothesis) involving SGA, low gestational age, genetic predisposition, and postnatal insults (hsPDA, sepsis and mechanical ventilation therapy) have been suggested to be associated with BPD (40,45). Duration of respiratory support and NICU stay were longer in infants subjected to CA in our study.…”

Section: Discussionmentioning

confidence: 46%

“…Another study reported that funisitis increases the risk of BPD (41). However, in many studies, no association found between the presence of placental funisitis and BPD (28,40,(42)(43)(44). The relationship between histopathological CA or subgroups and BPD is still unclear.…”

Section: Discussionmentioning

confidence: 99%

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Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Çakır

Yildiz²,

Kahvecioglu³

et al. 2018

TJPATH

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Objective: The microscopic and macroscopic features of the placenta can contribute to the clinical understanding of premature delivery. The aim of our study was to figure out the relationship between the histopathological findings of the placentas of premature deliveries and its effects on neonatal morbidity and mortality. Material and Method:The placentas of 284 singleton preterm infants with <35 weeks of gestation were examined. Three groups were created as the normal, chorioamnionitis and vasculopathy groups according to the histopathological findings in the placentas of the subjects. Results:The mean gestational age of the infants in the study group was 30.5 ± 3.2 weeks, and the mean birth weight was 1588 ± 581 g. The pathology was normal in ninety-six (33.8%), vasculopathy in 153 (53.9%) and chorioamnionitis in 35 (12.3%). The gestation age of the infants was lower in the chorioamnionitis group. Moreover, retinopathy of prematurity, early onset neonatal sepsis, and duration of respiratory support were found to be higher in the chorioamnionitis group. In the vasculopathy group, preeclampsia and small for gestational age were found to be significantly higher. Conclusion:Histopathological findings of the placentas from preterm deliveries provided important data in determining the etiology of preterm delivery and outcomes of infants. Infants delivered by mothers with chorioamnionitis were particularly found to be more preterm, and these preterm infants would have a longer hospital stay, higher respiratory support requirement, and more serious morbidities.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 46%

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Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Çakır

Yildiz²,

Kahvecioglu³

et al. 2018

TJPATH

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“…Moreover, the presence of FUN in association with HCA has previously showed a contrasting effect on the development of respiratory distress syndrome (RDS) or BPD. [26][27][28][29][30] This debating finding is probably due to different insults occurring in NICU, that is, long-time mechanical ventilation, high oxygen administration, and infections, those can in turn damage the lung. Furthermore, neonatal preterm lung, exposed to a prolonged inflammation during fetal life, could reacts in a more pathological way.…”

Section: Discussionmentioning

confidence: 99%

Early- and Late-Respiratory Outcome in Very Low Birth Weight with or without Intrauterine Inflammation

et al. 2020

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“…23 In particular, researchers of a recent population-based study strongly suggested that in homogeneous groups of extremely preterm infants, histologic chorioamnionitis is not associated with BPD. 24 Moreover, preceding exposure to intraamniotic inflammatory insult has been found to protect the lungs against BPD triggered by postnatal systemic inflammation in rats. 25 Nevertheless, the association between chorioamnionitis and BPD will probably continue to be debated as a complex amalgam of inflammatory preconditioning, placental inflammatory and postnatal injury to the developing lung, and many factors that are changing over time.…”

Section: Discussionmentioning

confidence: 99%

Placental Findings and Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants

Héneau¹,

Guimiot²,

Mohamed

et al. 2018

Pediatrics

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Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort

Cited by 32 publications

References 39 publications

Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Early- and Late-Respiratory Outcome in Very Low Birth Weight with or without Intrauterine Inflammation

Placental Findings and Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants

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