Cognitive performance of community-dwelling oldest-old individuals with major depression: the Pietà study

Dias, Filipi Leles da Costa; Teixeira, Antônio Lúcio; Guimarães, Henrique Cerqueira; Barbosa, Maira Tonidandel; Resende, Elisa de Paula França; Beato, Rogério; Carmona, Karoline Carvalho; Caramelli, Paulo

doi:10.1017/s1041610217000850

Cited by 18 publications

(18 citation statements)

References 25 publications

(23 reference statements)

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“…51 Depression was found to be associated with neurocognitive deficits in other patient populations. 52,53 However, assessment of neurocognitive functions showed no difference between those with depression and those without depression in this study, perhaps because this population in general has altered neurocognitive functioning due to SCD-associated neurological complications. Of 70 patients for whom data were available, 23% had a history of central nervous system events.…”

Section: Discussioncontrasting

confidence: 57%

Depression, quality of life, and medical resource utilization in sickle cell disease

et al. 2017

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Key Points• Depression was found in 35.2% of adult SCD patients and was strongly associated with worse physical and mental quality-of-life outcomes.• Total health care costs for adult SCD patients with depression were more than double those of SCD patients without depression.Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool.Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (P , .0001 and P , .0001, respectively). Mean total inpatient costs ($25 000 vs $7487, P 5 .02) and total health care costs ($30 665 vs $13 016, P 5 .01) were significantly higher in patients with depression during the 12 months preceding diagnosis. Similarly, during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients ($13 766 vs $8670, P 5 .04). Depression is prevalent in adult patients with SCD and is associated with worse HRQoL and higher total health care costs. Efforts should focus on prevention, early diagnosis, and therapy for depression in SCD.

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Section: Discussioncontrasting

confidence: 57%

Depression, quality of life, and medical resource utilization in sickle cell disease

et al. 2017

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“…The main differences revealed in the analysis were that general cognition was nonsignificant in the Suffering factor, but significant in the Motivation factor, and gender was more relevant in the Suffering factor. Our results corroborate the findings of previous studies, ie, that poorer cognition was associated with higher depression levels . The most relevant of our findings was that the association between a poor cognition and a higher depression only occurred in the Motivation factor.…”

Section: Discussionsupporting

confidence: 92%

“…Our results corroborate the association between depression and cognitive decline . The presence of depression favours lower cognitive performance, in the same way that cognitive performance influences and conditions the possible presence of depressive symptomatology.…”

Section: Discussionsupporting

confidence: 88%

Cognition and its association with the factors of the EURO‐D: Suffering and Motivation. Findings from SHARE Wave 6

Portellano-Ortiz

Conde-Sala

2018

Int J Geriat Psychiatry

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“…Impairment in cognitive function (CF) and DS often co‐occur among elderly people . Significant negative associations between CF and DS have been observed in several cross‐sectional and longitudinal analyses .…”

Section: Introductionmentioning

confidence: 99%

“…Impairment in cognitive function (CF) and DS often co-occur among elderly people. 10,11 Significant negative associations between CF and DS have been observed in several cross-sectional and longitudinal analyses. [12][13][14][15] Previous studies have hypothesized that people with cognitive deficits show early insight into their failing capacities and react to this loss with DS 16,17 or that both changes in CF and DS may be driven by underlying risk factors such as cerebrovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Interaction between worsening cognitive function and deteriorating functional status on depressive symptoms among Chinese community‐dwelling elders

Wang

Zhu

et al. 2020

Geriatrics Gerontology Int

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Aim Cognitive impairment and functional deterioration are common in later life and often co‐occur with depressive symptoms (DS). This study aims to examine the individual effects and possible interaction between worsening cognitive function (CF) and deteriorating functional status (FS) on DS using large sample, longitudinal data. Methods Elderly people who completed the baseline survey of China Health and Retirement Longitudinal Study (CHARLS 2011) and the third wave survey (2015) were included. A multivariable logistic regression model was used to assess the individual effects. The relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP) and synergy index (SI) were calculated to evaluate the additive interaction. Results Worsening CF and deteriorating FS were associated with the increase in DS, while unchanged or improved CF and FS were associated with the decrease in DS. In addition, decreased (increased) FS led to more severe (improved) DS than decreased (increased) CF. The additive interaction between worsening CF and deteriorating FS on the increase in DS was significant. The estimates and 95% CI of the RERI, AP and SI were 0.626 (0.061, 1.190), 0.222 (0.042, 0.402) and 1.526 (1.016, 2.291) respectively. Conclusions Both worsening CF and deteriorating FS have positive interactions with the increase in DS. It is vital to focus on DS of elderly people with worsening CF and/or FS and to adopt interventions. Geriatr Gerontol Int 2020; 20: 343–347.

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Cognitive performance of community-dwelling oldest-old individuals with major depression: the Pietà study

Cited by 18 publications

References 25 publications

Depression, quality of life, and medical resource utilization in sickle cell disease

Depression, quality of life, and medical resource utilization in sickle cell disease

Cognition and its association with the factors of the EURO‐D: Suffering and Motivation. Findings from SHARE Wave 6

Interaction between worsening cognitive function and deteriorating functional status on depressive symptoms among Chinese community‐dwelling elders

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