Association between three VEGF polymorphisms and renal cell carcinoma susceptibility: a meta-analysis

Abstract

Several studies have reported an association between vascular endothelial growth factor (VEGF) gene polymorphisms rs2010963, rs3025039 and rs699947 and renal cell carcinoma (RCC). However, the results remain inconclusive and controversial. We therefore conducted a meta-analysis to evaluate this association. Electronic databases were searched for relevant case-control studies up to November 2016. RevMan 5.2 software and STATA version 12.0 were used for statistical analysis in our meta-analysis. Heterogeneity was assessed using the I2 value. Nine eligible studies were retrieved for detailed evaluation. The pooled estimates indicated that the GG genotype of VEGF rs2010963 polymorphism significantly decreased RCC risk [GG vs. GC+CC; GG vs. GC]. There was also a significant association between VEGF rs3025039 polymorphism and RCC susceptibility [CC+CT vs. TT; CC vs. TT]. Furthermore, a significant association between VEGF rs699947 polymorphism and RCC susceptibility was detected [A vs. C; AA+AC vs. CC; AA vs. AC+CC; AA vs. CC; AA vs. AC; AC vs. CC]. Subgroup analysis revealed that these associations held true especially for Asians. Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.

Association of single nucleotide polymorphisms with renal cell carcinoma in Algerian population

“…Similarly to our results Sáenz-López and al [13] reported that -2578C/A, -460T/C, -405C/G, -936C/T VEGF polymorphisms do not appear to exert a significant effect on RCC risk in Spanish population. Regarding VHL gene polymorphisms (rs1642742 and rs779805), numerous studies have examined the association with development and/or prognosis of RCC but with inconclusive results [14,15] (Table 5). It has reported that the existence of G allele at both rs1642742 and rs779805 may play an important role in tumorigenesis of RCC through methylation of CpG island to suppress gene expression [15].…”

“…Regarding VHL gene polymorphisms (rs1642742 and rs779805), numerous studies have examined the association with development and/or prognosis of RCC but with inconclusive results [14,15] (Table 5). It has reported that the existence of G allele at both rs1642742 and rs779805 may play an important role in tumorigenesis of RCC through methylation of CpG island to suppress gene expression [15]. These discrepancies might depend on ethnicity or the different carcinoma types.…”

Survival prediction of kidney renal papillary cell carcinoma by comprehensive LncRNA characterization

“…Currently, several biomarkers for KIRC that have been detected include von Hippel-Lindau (VHL) [ 8 – 11 ], vascular endothelial growth factor (VEGF) [ 12 – 15 ], carbonic anhydrase IX (CAIX) [ 16 – 18 ], and hypoxia-inducible factor 1 alpha/2 alpha (HIF1a/2a) mutations [ 19 – 21 ], some of which were able to forecast the medical effectiveness and outcomes. Despite that, there have been scarce studies into the molecular biomarkers of KIRP for the prediction of therapeutic efficacy and prognostication.…”

Genetic and Epigenetic Mechanisms of Endometral Reciptivity Disorder in Patients Born with Low Weight

“…VEGF specifically binds to two transmembrane tyrosine kinase receptors (VEGFR) on endothelial cells for transduction of the intracellular signal required for angiogenesis [25]. According to several authors, carriage of the genotype CC / CA of the gene VEGF 2578 C> A is associated with an increase in the synthesis of VEGF-A in plasma and the risk of metastasizing a number of epithelial cancers; In contrast, the variant -2578A allele is associated with a decrease in the transcription of the AP-protease and the synthesis of VEGF-A in tissues [26][27]. A decrease in VEGF-A production may account for the low activity of angiogenesis in tissues, including endometrium, in carriers of the genotype AA / AC of the VEGF 2578 C> A gene [28].…”