Spontaneous alternation: A potential gateway to spatial working memory in Drosophila

Lewis, Sara A.; Negelspach, David C.; Kaladchibachi, Sevag; Cowen, Stephen L.; Fernandez, Fabian-Xosé

doi:10.1016/j.nlm.2017.05.013

Cited by 22 publications

(20 citation statements)

References 31 publications

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“…However, further work would have to be carried out to determine to what extent, if any, alternations and repetitions are implicated in short term memory in the Y-maze. Here, we confirmed that both alternations and repetitions remain as a highly reliable behavioral pattern that is conserved across species (Ghafouri et al 2016; Lewis et al 2017; Pickering et al 2015).…”

Section: Discussionsupporting

confidence: 79%

“…Interestingly, decreases in pure alternations and increases in pure repetition behavior in lateralized animals was first described by Rodriguez et al (1992), who demonstrated that both stress and over-training decrease the alternation/repetition ratio through the promotion of an increase of biased responses. Overall, we confirmed that both alternations and repetitions remain as a highly reliable behavioral pattern that is conserved across species (Ghafouri et al 2016; Lewis et al 2017; Pickering et al 2015).…”

Section: Discussionsupporting

confidence: 78%

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Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Fontana

Clay

Parker

2019

Preprint

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6Once considered a uniquely human attribute, behavioral laterality has proven to be 3 7 ubiquitous among non human animals, being frequently associated with different 3 8 neurophenotypes in rodents and fish species. Zebrafish (Danio rerio) are a versatile vertebrate 3 9 model system that has been widely used in translational neuropsychiatric research due their 4 0 highly conserved genetic homology, well characterized physiological and extensive behavioral 4 1 repertoire. Although the spontaneous left-and right-bias responses and associated behavioral 4 2 domains (e.g. stress reactivity, aggression and learning) have previously been observed in other 4 3 teleost species, no information regarding how spontaneous motor left-right bias responses of 4 4 zebrafish predicts other behavioral domains has been described. Thus, we aimed to investigate 4 5 the existence and incidence of natural left-right bias of adult zebrafish in the Y-maze test and 4 6 explore any relationship of biasedness on the performance of different behavioral domains. This 4 7 included learning about threat-cues in the fear conditioning test and locomotion and anxiety-4 8related behavior in the novel tank diving test. In conclusion, we showed for the first time that 4 9 handling in a single day (see Fig. 1). During the pair-housing period, animals had shared

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 78%

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Fontana

Clay

Parker

2019

Preprint

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“…This is likely related to how spontaneous alternation has evolved into a standard test for memory in transgenic rodent models of human conditions (e.g., O'Leary, Hussin, Gunn, & Brown, ; Snider & Obrietan, ) or evaluating effects of pharmacological agents (Hughes, ). However, spontaneous alternation has been observed in several other nonhuman organisms, including larval zebrafish (Bögli & Huang, ) and black molly fish (Creson, Woodruff, Ferslew, Rasch, & Monaco, ), ants (Czaczkes, Koch, Fröber, & Dreisbach, ), fruit flies ( Drosophila melanogaster ; Lewis, Negelspach, Kaladchibachi, Cowen, & Fernandez, ), paramecium (Harvey & Bovell, ), marmosets (Izumi, Tsuchida, & Yamaguchi, ), and in some species of crab (but not others—Balcı, Ramey‐Balcı, & Ruamps, ; Ramey, Teichman, Oleksiak, & Balci, ). In other species, evidence for spontaneous alternation behavior is debatable (lemurs, Dal‐Pan et al, ; chicks, Hayes & Warren, ; hens, Haskell, Forkman & Waddington, ) or contrary (e.g., pigeons, Hughes, ).…”

Section: Exploring Similarities and Differencesmentioning

confidence: 99%

The puzzle of spontaneous alternation and inhibition of return: How they might fit together

Phillmore

Klein

2019

Hippocampus

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Two isolated spatial phenomena share a similar “been there; done that” effect on spatial behavior. Originally discovered in rodent learning experiments, spontaneous alternation is a tendency for the organism to visit a different arm in a T‐maze on subsequent trials. Originally discovered in human studies of attention, inhibition of return is a tendency for the organism to orient away from a previously attended location. Whereas spontaneous alternation was identified by O'Keefe & Nadel as dependent on an intact hippocampus, inhibition of return is dependent on neural structures that participate in oculomotor control (the superior colliculus, parietal and frontal cortex). Despite the isolated literatures, each phenomenon has been assumed to reflect a basic novelty‐seeking process, avoiding places previously visited or locations attended. In this commentary, we explore and compare the behavioral manifestations and neural underpinnings of these two phenomena, and suggest what is still needed to determine whether they operate in parallel or serial.

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“…Because of the simple structure and convenient operation of automated Y-maze applications, more and more animal experiments have adopted the Y-maze to explore the learning and memory of animals (Ru and Liu, 2018). The numbers of arm entries and time spent in the new arm have been identified as well indices of short-term spatial memory (Lewis et al, 2017). The spontaneous alternation behavior, the time spent in the new arm, total distance and the total new arm distance were measured to assess the learning ability of the rats (Conrad et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Wang

Chen

Shen

et al. 2019

Front. Aging Neurosci.

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Amyloid-β (Aβ) deposits and some proteins play essential roles in the pathogenesis of Alzheimer's disease (AD). Amide proton transfer (APT) imaging, as an imaging modality to detect tissue protein, has shown promising features for the diagnosis of AD disease. In this study, we chose 10 AD model rats as the experimental group and 10 sham-operated rats as the control group. All the rats underwent a Y-maze test before APT image acquisition, using saturation with frequency alternating RF irradiation (APT SAFARI) method on a 7.0 T animal MRI scanner. Compared with the control group, APT (3.5 ppm) values of brain were significantly reduced in AD models (p < 0.002). The APT SAFARI imaging is more significant than APT imaging (p < 0.0001). AD model mice showed spatial learning and memory loss in the Y-maze experiment. In addition, there was significant neuronal loss in the hippocampal CA1 region and cortex compared with sham-operated rats. In conclusion, we demonstrated that APT imaging could potentially provide molecular biomarkers for the non-invasive diagnosis of AD. APT SAFARI MRI could be used as an effective tool to improve the accuracy of diagnosis of AD compared with conventional APT imaging.

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Spontaneous alternation: A potential gateway to spatial working memory in Drosophila

Cited by 22 publications

References 31 publications

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

The puzzle of spontaneous alternation and inhibition of return: How they might fit together

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

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