Mechanistic Role of Thioredoxin 2 in Heart Failure

Chen, Chaofei; Chen, Haixuan; Zhou, Huanjiao Jenny; Ji, Weidong; Wang, Min

doi:10.1007/978-3-319-55330-6_14

Cited by 8 publications

(5 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following stimulation, ASK1 dissociates from Trx and is activated by subsequent modifications. 32 In our study, excessive oxidative stress occurred 4 weeks after MI, whereas ZBTB20 overexpression decreased ROS production and preserved the level of anti-oxidants, leading to inactivation of ASK1. In addition, ZBTB20 also decreased inflammatory response post-MI and reduced production and release of TNFα, leading to inactivation of ASK1/JNK pathway.…”

Section: Discussionsupporting

confidence: 48%

Zinc Finger Protein ZBTB20 protects against cardiac remodelling post‐myocardial infarction via ROS‐TNFα/ASK1/JNK pathway regulation

Yang

Xue

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

This study aims to determine the efficacy of Zinc finger protein ZBTB20 in treatment of post‐infarction cardiac remodelling. For this purpose, left anterior descending (LAD) ligation was operated on mice to induce myocardial infarction (MI) with sham control group as contrast and adeno‐associated virus (AAV9) system was used to deliver ZBTB20 to mouse heart by myocardial injection with vehicle‐injected control group as contrast two weeks before MI surgery. Then four weeks after MI, vehicle‐treated mice with left ventricular (LV) remodelling underwent deterioration of cardiac function, with symptoms of hypertrophy, interstitial fibrosis, inflammation and apoptosis. The vehicle‐injected mice also showed increase of infarct size and decrease of survival rate. Meanwhile, the ZBTB20‐overexpressed mice displayed improvement after MI. Moreover, the anti‐apoptosis effect of ZBTB20 was further confirmed in H9c2 cells subjected to hypoxia in vitro. Further study suggested that ZBTB20 exerts cardioprotection by inhibiting tumour necrosis factor α/apoptosis signal‐regulating kinase 1 (ASK1)/c‐Jun N‐terminal kinase 1/2 (JNK1/2) signalling, which was confirmed by shRNA‐JNK adenoviruses transfection or a JNK activator in vitro as well as ASK1 overexpression in vivo. In summary, our data suggest that ZBTB20 could alleviate cardiac remodelling post‐MI. Thus, administration of ZBTB20 can be considered as a promising treatment strategy for heart failure post‐MI. Significance Statement: ZBTB20 could alleviate cardiac remodelling post‐MI via inhibition of ASK1/JNK1/2 signalling.

show abstract

Section: Discussionsupporting

confidence: 48%

Zinc Finger Protein ZBTB20 protects against cardiac remodelling post‐myocardial infarction via ROS‐TNFα/ASK1/JNK pathway regulation

Yang

Xue

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Myocardial cell apoptosis is central to the pathogenesis of HF. 39 Therefore, the effect of tolvaptan/valsartan combination on the apoptosis of heart and kidney tissues in Dox-treated mice was evaluated by TUNEL assay. As indicated in Figure 5 A,B, increased number of TUNEL-positive cells were detected in heart and kidney tissues of mice in the model group.…”

Section: Combination Of Tolvaptan and Valsartan Reduced Cell Apoptosi...mentioning

confidence: 99%

Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice

Yan

Zhu

et al. 2022

Eur J Histochem

View full text Add to dashboard Cite

Heart failure (HF) is often complicated by renal dysfunction. Tolvaptan and valsartan are two well-known agents for the treatment of HF. However, the role of tolvaptan/valsartan combination on HF with renal dysfunction remains unclear. To establish a mice model with HF with renal dysfunction, mice were intraperitoneally injected with doxorubicin (Dox). Echocardiogram was applied to assess the left ventricular function. Additionally, serum aldosterone (ALD) and angiotensin II (Ang II) level in mice were determined by ELISA. Meanwhile, western blot assay was used to evaluate the expressions of B cell lymphoma-2 (Bcl-2), Bcl-2 associated X (Bax) and cleaved caspase 3 in the heart and kidney tissues of mice. In this study, we found that compared to tolvaptan or valsartan alone treatment group, tolvaptan/valsartan combination obviously improved the left ventricular ejection fraction (LVEF) and the left ventricular fractional shortening (LVFS), and reduced serum ALD and Ang II level in Dox-treated mice. Additionally, tolvaptan/valsartan combination significantly prevented the inflammation and fibrosis of heart and kidney tissues in Dox-treated mice. Meanwhile, tolvaptan/valsartan combination notably inhibited the myocardial and renal cell apoptosis in Dox-treated mice via upregulation of Bcl-2 and downregulation of Bax and cleaved caspase 3, compared to the single drug treatment. Collectively, tolvaptan/valsartan combination could improve cardiac and renal functions, as well as prevent the fibrosis, inflammation and apoptosis of heart and kidney tissues in Dox-treated mice. Taken together, combining tolvaptan with valsartan might be a promising approach to achieve enhanced therapeutic effect for treatment of HF with renal dysfunction.

show abstract

“…GSSG is then recycled by GSH reductase (GR) 9 . Recent studies have established an important role of the Trx antioxidant system in HF 10,11 . GSH has also been implicated in cardiovascular diseases, however, only recently have the enzymes of the GSH synthesis and salvage pathways been implicated in HF [12][13][14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction

Pol

Gil

Tromp

et al. 2018

Cardiovascular Research

View full text Add to dashboard Cite

show abstract

Mechanistic Role of Thioredoxin 2 in Heart Failure

Cited by 8 publications

References 70 publications

Zinc Finger Protein ZBTB20 protects against cardiac remodelling post‐myocardial infarction via ROS‐TNFα/ASK1/JNK pathway regulation

Zinc Finger Protein ZBTB20 protects against cardiac remodelling post‐myocardial infarction via ROS‐TNFα/ASK1/JNK pathway regulation

Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice

OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction

Contact Info

Product

Resources

About