MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor

Islam, Farhadul; Gopalan, Vinod; Vider, Jelena; Wahab, Riajul; Ebrahimi, Faeza; Lu, Cu-Tai; Kasem, Kais; Lam, Alfred King-Yin

doi:10.1016/j.yexcr.2017.05.021

Cited by 60 publications

(58 citation statements)

References 43 publications

(65 reference statements)

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“…Islam et al found miR-186-5p overexpressed in CRC tissues compared to non-cancer samples and moreover, this expression was correlated with distant metastasis, lymphovascular permeation, and poor prognosis. In addition, the overexpression of miR-186-5p promotes cell proliferation, migration and colony formation by inhibiting the tumor suppressor family with sequence similarity 134, member B (FAM134B) [36]. Recently, Qu et al found significant overexpression of miR-186-5p in serum samples from CRC patients with lymph node metastasis, which could suggest its involvement in the metastatic process [37].…”

Section: Discussionmentioning

confidence: 99%

A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis

Rapado‐González

Majem

Álvarez-Castro

et al. 2019

JCM

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Salivary microRNAs (miRNAs) are of high interest as diagnostic biomarkers for non-oral cancer. However, little is known about their value for colorectal cancer (CRC) detection. Our study aims to characterize salivary miRNAs in order to identify non-invasive markers for CRC diagnosis. The screening of 754 miRNAs was performed in saliva samples from 14 CRC and 10 healthy controls. The differential expressed miRNAs were validated by RT-qPCR in 51 CRC, 19 adenomas and 37 healthy controls. Receiver operating characteristic (ROC) curves and logistic regression models were performed to analyze the clinical value of these miRNAs. Twenty-two salivary miRNAs were significantly deregulated in CRC patients vs. healthy individuals (P < 0.05) in the discovery phase. From those, five upregulated miRNAs (miR-186-5p, miR-29a-3p, miR-29c-3p, miR-766-3p, and miR-491-5p) were confirmed to be significantly higher in the CRC vs. healthy group (P < 0.05). This five-miRNA signature showed diagnostic value (72% sensitivity, 66.67% specificity, AUC = 0.754) to detect CRC, which was even higher in combination with carcinoembryonic antigen (CEA) levels. Overall, after the first global characterization of salivary miRNAs in CRC, a five-miRNA panel was identified as a promising tool to diagnose this malignancy, representing a novel approach to detect cancer-associated epigenetic alterations using a non-invasive strategy.

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Section: Discussionmentioning

confidence: 99%

A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis

Rapado‐González

Majem

Álvarez-Castro

et al. 2019

JCM

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“…Similar observations were also reported in colorectal cancer. Islam et al (30) demonstrated that miR-186 overexpression significantly decreased the expression of RETREG1 in colorectal cancer cells, and the expression levels of RETREG1 and miR-186 were inversely correlated in colorectal cancer tissues and cells. The current study expanded the understanding of the association between miR-186 and RETREG1 in human cancer.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1

Liu

et al. 2019

Exp Ther Med

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MicroRNAs (miRs), a class of small non-coding RNAs, have been demonstrated to be involved in the development and progression of human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR-186 serves a suppressive role in certain common types of human cancer; however, its exact function in CSCC has not been reported previously. In the present study, the expression of miR-186 was significantly increased in CSCC tissues compared with adjacent non-tumour tissues. Overexpression of miR-186 significantly promoted CSCC cell proliferation while inhibiting cell apoptosis. Reticulophagy regulator 1 (RETREG1), a gene that is significantly downregulated in CSCC tissues and cell lines, was identified as a novel target of miR-186. In addition, the expression of RETREG1 was inversely correlated with miR-186 expression in CSCC tissues. Furthermore, the expression of RETREG1 was negatively regulated by miR-186 in CSCC cells, and restoration of RETREG1 attenuated the effects of miR-186 on CSCC cells. Taken together, the results of the current study suggest that miR-186 serves an oncogenic role in CSCC and may be used as a potential therapeutic target for the treatment of this disease.

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“…miR-186 role in colorectal cancer pathogenesis is not so clear. Some reports have identified miR-186 [5p] as a tumor suppressor due to its ability to inhibit proliferation, metastasis and EMT of colorectal cancer cells by targeting ZEB1, while others point out in the opposite direction (127)(128)(129).…”

Section: Mir-186mentioning

confidence: 99%

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

2020

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Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. PVT1 expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of PVT1 as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.

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MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor

Cited by 60 publications

References 43 publications

A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis

A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis

MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

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