A rare presentation of metastatic prostate cancer, initially a suspect for urothelial cell carcinoma of the ureter: a case report

Abstract

BackgroundThe most common metastatic sites of prostate cancer are the lymph nodes and bone. Ureteral metastasis from prostate cancer is very unusual and only a few cases have been reported.Case presentationWe describe a 76-year-old male with ureteral metastasis of prostate cancer along with a review of the literature. Initially, based on the diagnostic evaluation, urothelial cell carcinoma of the left distal ureter was suspected. Nephroureterectomy with bladder cuff excision was performed. The final pathologic diagnosis was prostate cancer metastatic to the ureter.ConclusionAlthough rare and the mechanistic link between prostate cancer and distant ureteral metastasis has not been clarified on a clinical basis, this would be included in the differential diagnosis of ureteral lesions in patients with a history of prostate cancer. It is important to recognize this unusual manifestation so that timely appropriate treatment can be initiated.

An Unusual Case of Acute Appendicitis due to Metastatic Prostatic Adenocarcinoma

“…The appendix is an unusual site of metastatic spread of prostatic adenocarcinoma. Other uncommon sites of spread of prostatic adenocarcinoma include the breast, brain, stomach, ureter, and rectum [ 6 – 8 ].…”

https://researchopenworld.com/metastatic-prostate-cancer-to-the-renal-pelvis-and-proximal-ureter-a-case-report-and-review-of-the-literature/#

“…The low incidence of mPCa to the ureters and renal pelvis is hypothesized to be a result of the lymphatic circulation of the ureter, which is segmental and drains diagonally or transversely, with no continuous longitudinal lymphatic network draining directly from the prostatic region. 7 One proposed mechanism for metastasis involves dissemination of malignant cells to the retroperitoneal lymph nodes near the ureter via the periureteral lymphatic pathway [13]. Yonneau et al further added that the secondary tumor develops from the adventitia prior to invading the ureteric wall [14].…”