Potencial uso terapéutico de cannabis

L, Marcia Avello; N, Edgar Pastene; R, Pola Fernández; M, Pia Córdova

doi:10.4067/s0034-98872017000300010

Cited by 13 publications

(10 citation statements)

References 40 publications

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“…Here, types CB 1 and CB 2 predominate, and can be found in a high number of brain areas of the basal ganglia, hippocampus, cerebellum, frontal neocortical, cortex frontal, and the anterior cingulate. In this sense, research studied should focus on the development of medicines that act on receptors CB 1 and CB 2 , as they seem to cause certain speci c therapeutic effects, as the antiepileptic, analgesic, anti-in ammatory, among others (Avello et al, 2017;Burns et al, 2007;Castro et al, 2016;Cavuoto et al, 2007;Crean et al, 2011;Eldreth et al, 2004;Herkenham et al, 1991;Matsuda, 1990;Mackie, 2008;Sevy et al, 2008;Iversen, 2003) For the reasons above exposed, the purpose of this exploratory re ective study emerges as a basis to foster higher awareness on the effects of THC consumption. The following research question is then posed:…”

Section: Social Responsibility and Integral Educationmentioning

confidence: 99%

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design. Why the Exponential Increase in Psychotropics?

Marulanda

Giraldo

Arroyave

2021

Preprint

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Background: For public health fields, it is fundamental to understand the exponential the reasons behind the consumption increase in 9-Delta-Tetrahydrocannabinol (THC) and other psychotropics. Estimate relationships between THC consumption and psychosocial variables (PSVs) among students and professors at a Colombian university.Methods: This observational descriptive cross-sectional study was developed between 2016 and 2018 with a total of 160 university students and 60 professors from a Colombian public university of one pharmaceutical chemistry program. Using an instrument based on the Children's Depression Inventory (CDI) survey designed by Kovacs (1977), participants were surveyed directly, voluntarily, and anonymously about marijuana use and different psychosocial variables of everyday life. Correlation of variables was analysed using the Statistical Package for the Social Sciences (SPSS), version 24, 2016. In each variable, risk factors were analysed using "Chi-square" and "Odds Ratio". Results: The findings show a significant relationship between THC consumption and PSVs in the students or the professors (S/P) group (59.8%): first time THC consumption (83%), low self-esteem (66.7%), decrease/loss of executive function (55.6%), no family support (55.6%), and no family communication (72.2%). These groups presented a relationship between risk and consumption of THC, which induces to neuro-psychosocial disorders.Conclusion: THC consumption and PSVs are prevalent in the S/P group, thus inducing a neuro-cognitive disorder. Although consumption increases exponentially at an alarmingly early age and national regulations are poor, there exists an unpredictable multidimensional impact., more scientific research is needed with a serious focus, political will, and integrative intersectorial educational interventions. Also, there is little knowledge on the potential effects of Δ9-THC in university student and professor populations. The Δ9-THC cannabinoids may have therapeutic and adverse effects, which bears interest for public health.

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Section: Social Responsibility and Integral Educationmentioning

confidence: 99%

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design. Why the Exponential Increase in Psychotropics?

Marulanda

Giraldo

Arroyave

2021

Preprint

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“…CB 2 R was thought to be primarily expressed in microglial cells, especially activated microglial cells [41]. However, this theory has been challenged by recent studies that have found CB 2 R expressed in numerous brain areas [42,43], including ventral tegmental area dopaminergic neurons [44], which also express CB 1 R [45]. Dopaminergic CB 2 R plays an important role in modulating dopaminergic neuronal activity and dopaminerelated functions [44], inhibiting psychomotor behaviors, and altering anxiety, depression, alcohol dependence [46], and cacaine-induced locomotor-stimulating effects [47].…”

Section: The Endocannabinoid Systemmentioning

confidence: 99%

Integrating endocannabinoid signaling in the regulation of anxiety and depression

2018

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Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism's long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of the underlying neural cell populations and neural circuit regulation will enable the development of therapeutic strategies to mitigate behavioral maladaptation and provide insight into the influence of eCB on the neural circuits involved in anxiety and depression. This review focuses on recent evidence that has added a new layer of complexity to the idea of targeting the eCB system for therapeutic benefits in neuropsychiatric disease and on the future research direction of neural circuit modulation.

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“…Among the most important endogenous cannabinoid (ECs) neurotransmitter is arachidonoyl ethanolamide (or anandamide -AEA), [1,7] being agonists of such receptor [8].…”

Section: Introductionmentioning

confidence: 99%

“…If it is presynaptic and with adenylate Cyclase inhibition, it may be generated hyperpolarization with a consequent decrease in neurotransmitter release. If it is postsynaptic, the action of rCB1 is on K + channel regulation and adenylate cyclase inhibition [7,9]. The neuromodulatory action of AEA is due to the following characteristics: they have distinct synthetic pathways; their cell release occurs after membrane depolarization and calcium intake; and its action is terminated with its reuptake and degradation by an intracellular enzyme (fatty acid amide hydrolase) [10].…”

Section: Introductionmentioning

confidence: 99%

Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity

Correia

Ferreira

Lima

et al. 2021

Preprint

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Search for new pharmacological alternatives for obesity is based on the design and development of compounds that can aid in weight loss so that they can be used safely and effectively over a long period while maintaining their function. The endocannabinoid system is related to obesity by increasing orexigenic signals and reducing satiety signals. Cannabis sativa is a medicinal plant of polypharmaceutical potential that has been widely studied for various medicinal purposes. The in silico evaluation of their natural cannabinoids (also called phytocannabinoids) for anti-obesity purpose stems from the existence of synthetic cannabinoid compounds that have already presented this result, but which did not guarantee patient safety. In order to find new molecules from C. sativa phytocannabinoids, with the potential to interact with the pharmacological target cannabinoid receptor 1, a pharmacophore-based virtual screening was performed, including the evaluation of physicochemical, pharmacokinetic, toxicological predictions and molecular docking. The results obtained from the ZINC12 database pointed to Zinc 69 (ZINC33053402) and Zinc 70 (ZINC19084698) molecules as promising anti-obesity agents. Molecular Dynamics (MD) studies discloses that both complexes were stable by analyzing the RMSD (Root Mean Square Deviation) values, and the binding free energy values demonstrate that the selected structures can interact and inhibit their catalytic activity.

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Potencial uso terapéutico de cannabis

Abstract: (Rev Med Chile 2017; 145: 360-367)

Cited by 13 publications

References 40 publications

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design. Why the Exponential Increase in Psychotropics?

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design. Why the Exponential Increase in Psychotropics?

Integrating endocannabinoid signaling in the regulation of anxiety and depression

Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity

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Potencial uso terapéutico de cannabis

Abstract: (Rev Med Chile 2017; 145: 360-367)

Cited by 13 publications

References 40 publications

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design.&nbsp;Why the Exponential Increase in Psychotropics?

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design.&nbsp;Why the Exponential Increase in Psychotropics?

Integrating endocannabinoid signaling in the regulation of anxiety and depression

Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity

Contact Info

Product

Resources

About

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design. Why the Exponential Increase in Psychotropics?

Studying Relationships Tetrahydrocannabinol Consumption and Psychosocial Variables in a Campus: Potential Contributions to Policy Design. Why the Exponential Increase in Psychotropics?