Hyperbaric oxygen therapy for wound healing in diabetic rats: Varying efficacy after a clinically-based protocol

Neck, Johan W. van; Tuk, Bastiaan; Fijneman, Esther M.G.; Redeker, Jonathan J; Talahatu, Edwin M; Tong, Miao

doi:10.1371/journal.pone.0177766

Cited by 19 publications

(6 citation statements)

References 28 publications

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“…Professional sports teams have also favored the use of HBOT to speed injury ( Strauss et al, 1983 ; Strauss and Hart, 1984 ; Skyhar et al, 1986 ; Cianci and Sato, 1994 ; Goldfarb et al, 2016 ). Moreover, several studies have proposed that HBOT mobilizes stem cells by improving homing and subsequent engraftment in injured tissues, which would explain, in part, the therapeutic effects of HBOT ( Zádori et al, 2011 ; van Neck et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

et al. 2018

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Hyperbaric oxygen therapy (HBOT) is effective for the medical treatment of diverse diseases, infections, and tissue injury. In fact, in recent years there is growing evidence on the beneficial effect of HBOT on non-healing ischemic wounds. However, there is still yet discussion on how this treatment could benefit from combination with regenerative medicine strategies. Here we analyzed the effects of HBOT on three specific aspects of tissue growth, maintenance, and regeneration: (i) modulation of adult rodent (Mus musculus) intestinal stem cell turnover rates; (ii) angiogenesis dynamics during the development of the chorio-allantoic membrane (CAM) in Gallus gallus embryos; (iii) and wound-healing in a spontaneous type II diabetic mouse model with a low capacity to regenerate skin. To analyze these aspects of tissue growth, maintenance, and regeneration, we used HBOT alone or in combination with cellular therapy. Specifically, Wharton Jelly Mesenchymal Stem cells (WJ-MSC) were embedded in a commercial collagen-scaffold. HBOT did not affect the metabolic rate of adult mice nor of chicken embryos. Notwithstanding, HBOT modified the proliferation rate of stem cells in the mice small intestinal crypts, increased angiogenesis in the CAM, and improved wound-healing and tissue repair in diabetic mice. Moreover, our study demonstrates that combining stem cell therapy and HBOT has a collaborative effect on wound-healing. In summary, our data underscore the importance of oxygen tension as a regulator of stem cell biology and support the potential use of oxygenation in clinical treatments.

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Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

et al. 2018

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“…Also blood flow in the micro circulation showed a significant increase on days 17, 21 and 31 but a significant decrease on days 24 and 28. Inflammation scoring showed significantly decreased CD68 counts in the HBOT group on day 42, but not in the early stages of wound healing (28).…”

Section: Discussionmentioning

confidence: 86%

Effectiveness of Hyperbaric Oxygen Therapy for Wound Healing in Patient with Diabetic Foot Ulcer: A Mini Re- view

Jamaludin¹

2019

Int J Care Scholars

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Diabetes mellitus (DM) is a metabolic disease in which the body has difficulty producing insulin which leads to high blood glucose levels. Consequently, people suffering from DM can have damage organs, blood vessels, and nerves which resulting in getting diabetic foot ulcer (DFU). Other therapeutic interventions are offered if the DFU does not heal with normal standard wound care. One of which is hyperbaric oxygen therapy (HBOT) that will increase the oxygen supply to wounds. However, the effectiveness of this therapy is not clearly known until the present. Thus, the review of this paper aimed to report on the results of the analysis of research that focuses on the effect HBOT on diabetic foot ulcer healing. Relevant literature was searched in Google Scholar and PubMed used keywords â€œhyperbaric oxygen therapy" "diabetic foot ulcer" "wound healing", and â€œchronic ulcerâ€. Five articles that met the inclusion criteria based on the results of the analysis. Although there was some indication of a beneficial effect of the wound healing process, it is currently unknown which patients are likely to benefit from HBOT and which patients are not.

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“…Previous studies revealed that vibration and hyperbaric oxygen therapies remarkably improve muscle ischemia and attenuate ulceration after severe pressure loading. 15,43 Therefore, the application of both therapies should be preferentially considered to prevent the occurrence or deterioration of deep PIs in patients with the CT + TT genotype of HIF1A rs11549465.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross‐sectional study at a long‐term care hospital

Tsukatani

Minematsu

Dai

et al. 2021

Wound Repair Regeneration

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Advances in patient care for pressure injuries (PIs) have reduced the prevalence of PIs in Japan, although not in recent years. Several single-nucleotide polymorphisms (SNPs) have been identified in genes potentially associated with PIs. However, individual variance among PI risks require targeted investigations that may lead to the identification of PI susceptibilities or preventive care options that directly influence PI development pathways. This cross-sectional study examined the association between PIs and SNPs in genes related to tissue tolerance in patients in a long-term care hospital in Japan. A total of 178 participants (130 control, 20 with superficial PI history, and 28 with deep PI history) were enrolled in this study of eight SNPs in hypoxia inducible factor 1 subunit alpha (HIF1A), vascular endothelial growth factor C (VEGFC), heat shock protein 90 alpha family class A member 1 (HSP90AA1), myostatin (MSTN), and vitamin D receptor (VDR). The primary outcome was a history of superficial and deep PIs in the last 6 months. SNPs were examined by real-time polymerase chain reaction, followed by multivariate logistic regression analyses of the associations between the SNPs and PI history. The results showed a significant association between VEGFC rs1485766 and the history of superficial PIs (odds ratio = 2.95; 95% confidence interval = 1.07-8.11; p = 0.04). Stratified analysis using the Braden Scale (≤14) indicated a significant association between HIF1A rs11549465 and deep PIs (p = 0.04). Our study demonstrated that VEGFC rs1485766 and HIF1A rs11549465 were associated with superficial and deep PI susceptibilities, respectively.disease susceptibility, hypoxia-inducible factor 1, single-nucleotide polymorphism, vascular endothelial growth factor C | INTRODUCTIONA pressure injury (PI) is defined as a localized injury to the skin and/or underlying tissue caused by external forces. 1 Compared with the prevalence of PIs, which range from 2.8% to 28.8% in the United States 2 and 3.4% to 14.5% in Germany and Sweden, 3 Japan has a relatively low PI prevalence, which ranges from 0.77% to 2.81% (Survey of the Japanese Society of Pressure Ulcers, 2018). PIs reduce the quality of life of patients owing to the pain and discomfort they cause. 4 Furthermore, failure to heal in patients leads to higher mortality rates and an

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Hyperbaric oxygen therapy for wound healing in diabetic rats: Varying efficacy after a clinically-based protocol

Cited by 19 publications

References 28 publications

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

Effectiveness of Hyperbaric Oxygen Therapy for Wound Healing in Patient with Diabetic Foot Ulcer: A Mini Re- view

Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross‐sectional study at a long‐term care hospital

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