Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure

Guiloski, Izonete Cristina; Ribas, João Luiz Coelho; Piancini, Laércio Dante Stein; Dagostim, Ana Carolina; Círio, Silvana Maris; Fávaro, Luís Fernando; Boschen, Suelen Lúcio; Cestari, Marta Margarete; Cunha, Cláudio Da; Assis, Helena C. Silva de

doi:10.1016/j.etap.2017.05.005

Cited by 69 publications

(27 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Guiloski et al ( 2017 ) demonstrated the disruption of hypothalamic-pituitary-gonadal axis and severe changes of hematological parameters, i.e., mild blood congestion, leukocyte infiltration, and reduction of hemoglobin and hematocrit in male fish of Rhamdia quelen after exposure to environmental concentrations of paracetamol in a semi-static bioassay during 21 days. Freitas et al ( 2015 ) investigated the effects of ecologically relevant concentrations (25 μg/L) of paracetamol on Polychaete Diopatra neapolitana regenerative tissue capacity.…”

Section: Monocyclic Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria

Żur

Piński

Marchlewicz

et al. 2018

Environ Sci Pollut Res

196

View full text Add to dashboard Cite

Currently, analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are classified as one of the most emerging group of xenobiotics and have been detected in various natural matrices. Among them, monocyclic paracetamol and ibuprofen, widely used to treat mild and moderate pain are the most popular. Since long-term adverse effects of these xenobiotics and their biological and pharmacokinetic activity especially at environmentally relevant concentrations are better understood, degradation of such contaminants has become a major concern. Moreover, to date, conventional wastewater treatment plants (WWTPs) are not fully adapted to remove that kind of micropollutants. Bioremediation processes, which utilize bacterial strains with increased degradation abilities, seem to be a promising alternative to the chemical methods used so far. Nevertheless, despite the wide prevalence of paracetamol and ibuprofen in the environment, toxicity and mechanism of their microbial degradation as well as genetic background of these processes remain not fully characterized. In this review, we described the current state of knowledge about toxicity and biodegradation mechanisms of paracetamol and ibuprofen and provided bioinformatics analysis concerning the genetic bases of these xenobiotics decomposition.

show abstract

Section: Monocyclic Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria

Żur

Piński

Marchlewicz

et al. 2018

Environ Sci Pollut Res

196

View full text Add to dashboard Cite

show abstract

“…They are not subjected to regular monitoring but they could enter the environment and pose or cause adverse ecological and human health effects. 1 Though these drugs typically pass rigorous tests for their safety at normal dose thresholds, their compiling residues in the environment have been linked to behavioral changes [2][3][4] and endocrine disruption [5][6][7] of some aquatic organisms. In addition, pharmaceutical residues, antibiotics in particular, have been associated with the emergence of antibiotic-resistant microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Systematic investigation of the adsorption potential of lignin- and cellulose-based nanomaterials towards pharmaceuticals

Agustin

Mikkonen

Kemell

et al. 2022

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

“…The influence of paracetamol on dopaminergic neurotransmission has been confirmed by many researchers. In a study with male fish Rhamdia quelen subchronically exposed to paracetamol (0.25 μg/L) an anti‐androgenic effect and increase in level of DA and 5‐HT in whole brain was found (Guiloski et al, 2017). Researchers suggest that the anti‐androgenic effect of paracetamol (decrease of testosterone concentration and an increase of plasma estradiol level) is a consequence of hypothalamic‐pituitary‐gonadal axis disruption and can compromise the reproduction.…”

Section: Discussionmentioning

confidence: 99%

Hypothalamus – Response to early paracetamol exposure in male rats offspring

Blecharz-Klin

Wawer

Pyrzanowska

et al. 2019

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

One of the reasons for using paracetamol during pregnancy is fever. The brain structure responsible for maintaining proper body temperature, but also for controlling some endocrine aspects is hypothalamus. In this study we examined the effect of early pretreatment of paracetamol on hypothalamic neurotransmission in rats' offspring. We used two‐month old rats previously exposed to paracetamol at doses of 5 (P5) and 15 mg/kg (P15) during gestational development and next postnatally. The concentration of monoamines, their metabolites and amino acids in hypothalamus was chromatographically determined. The results of biochemical analysis were compared with the Control animals (Con). We found differences between groups in the concentration of main noradrenaline metabolite in hypothalamus. The control group had significantly higher level of 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) compared with rats exposed to paracetamol (F(2,27) = 7.96, p < 0.005). Simultaneously the level of dopamine (DA) (F(2,27) = 4.33, p < 0.05) and its metabolite ‐ homovanillic acid (HVA) (F(2,27) = 17.03, p < 0.005) was increased in the hypothalamus of animals treated with lower dose of the drug. Biochemical analyses show an increase in 3,4‐dihydroxyphenyl acetic acid (DOPAC) concentration in P5 group compared to the control rats and group treated with higher dose of paracetamol (F(2,27) = 7.37, p < 0.005). In the hypothalamus significant decrease of glutamic acid concentration was also observed in the group treated with paracetamol at dose of 5 mg. These results demonstrated that paracetamol had a significant effect on dopaminergic and noradrenergic neurotransmission and changed the concentration of glutamic acid in hypothalamus ‐ heat‐regulating center and important element of hypothalamic‐pituitary‐ gonadal axis.

show abstract

Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure

Cited by 69 publications

References 50 publications

Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria

Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria

Systematic investigation of the adsorption potential of lignin- and cellulose-based nanomaterials towards pharmaceuticals

Hypothalamus – Response to early paracetamol exposure in male rats offspring

Contact Info

Product

Resources

About