Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a GMP-Compliant Tissue-Engineered Medicine

Elliott, Martin J.; Butler, Colin R.; Varanou-Jenkins, Aikaterini; Partington, L.; Carvalho, Carlos Augusto Brandão de; Samuel, Edward; Crowley, Claire; Lange, Peggy; Hamilton, Nicholas; Hynds, Robert E.; Ansari, Tahera; Sibbons, Paul; Fierens, Anja; McLaren, C. A.; Roebuck, Derek; Wallis, Colin; Muthialu, Nagarajan; Hewitt, Richard; Crabbe, David; Janes, Sam M.; Coppi, Paolo De; Lowdell, Mark W.; Birchall, Martin A.

doi:10.1002/sctm.16-0443

Cited by 88 publications

(79 citation statements)

References 41 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Butler et al () also reported that the vacuum‐assisted decellularization of tracheal graft results better graft for clinical application. Clinical study of acellular graft was done for the tracheal tissue reconstruction (Elliott et al, ; Etienne et al, ; Li et al, ; Martinod et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

show abstract

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…Many types of tissue-engineered grafts used clinically to replace the trachea have been reported. 20 To date, 14 patients have clinically received bioengineered tracheas. Information gathered from published reports on these 3 patients and unpublished reports on an additional 11 patients suggests that mortality and morbidity were very high.…”

Section: Discussionmentioning

confidence: 99%

Tracheal Replacement Using an In-Body Tissue-Engineered Collagenous Tube “BIOTUBE” with a Biodegradable Stent in a Beagle Model: A Preliminary Report on a New Technique

Hiwatashi¹,

Nakayama

Umeda

et al. 2018

Eur J Pediatr Surg

View full text Add to dashboard Cite

Introduction Tracheal reconstruction for long-segment stenosis remains challenging. We investigate the usefulness of BIOTUBE, an in-body tissue-engineered collagenous tube with a biodegradable stent, as a novel tracheal scaffold in a beagle model. Materials and Methods We prepared BIOTUBEs by embedding specially designed molds, including biodegradable stents, into subcutaneous pouches in beagles. After 2 months, the molds were filled with ingrown connective tissues and were harvested to obtain the BIOTUBEs. The BIOTUBEs, cut to 10- or 20-mm lengths, were implanted to replace the same-length defects in the cervical trachea of five beagles. Endoscopic and fluoroscopic evaluations were performed every week until the lumen became stable. The trachea, including the BIOTUBE, was harvested and subjected to histological evaluation between 3 and 7 months after implantation. Results One beagle died 28 days after 20-mm BIOTUBE implantation because of insufficient expansion and retention force of the stent. The remaining four beagles were implanted with a BIOTUBE reinforced by a strong stent, and all survived the observation period. Endoscopy revealed narrowing of the BIOTUBEs in all four beagles, due to an inflammatory reaction, but patency was maintained by steroid application at the implantation site and balloon dilatation against the stenosis. After 2 months, the lumen gradually became wider. Histological analyses showed that the internal surface of the BIOTUBEs was completely covered with tracheal epithelial cells. Conclusion This study demonstrated the usefulness of the BIOTUBE with a biodegradable stent as a novel scaffold for tracheal regeneration.

show abstract

“…Second, coagulation of transplantation site edge can be considered to induce angiogenesis at least 7 days before surgery (J. Donnez et al, ). Third, the patient may be administered human recombinant erythropoietin during and after the surgery to increase (Elliott, Butler et al, ). Additionally, potential vessels for anastomosis can be identified and utilised as in the case of an entire ovary transplantation graft (Mhatre & Mhatre, ; Mhatre, Mhatre, Modi, & Doshi, ; Raya‐Rivera, Esquiliano, Yoo et al, ; Raya‐Rivera, Esquiliano, Fierro‐Pastrana et al, ).…”

Section: Transplantation Sites and Surgical Considerationsmentioning

confidence: 99%

A new possibility in fertility preservation: The artificial ovary

Cho

Kim

Noh

et al. 2019

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Conventional fertility preservation methods such as oocyte or embryo cryopreservation are currently insufficient to treat including those patients with prepubertal cancer and premature ovarian failure. Ovarian tissue cryopreservation presents as an alternative but has limitations with a potential risk of reintroducing malignant cells in patients who recover from cancer, those of chemotherapy prior to tissue cryopreservation. The so called “artificial ovary” aims to resolve this issue by transplanting isolated follicles with or without a biological scaffold. The artificial ovary may also offer an effective alternative option for those who cannot benefit from traditional assisted reproductive techniques such as in vitro fertilisation. To date, in animal studies and human trial, the artificial ovary restored endocrine function, achieved in vivo follicular development, and resulted in successful pregnancies. However, development of a technique for higher follicular recovery rate and a more optimised design of delivery scaffold, better transplantation techniques to prevent postsurgical ischemia, and consideration for genetic safety are required for safer and consistent human clinical applications. Ideas from different transplantation surgeries (e.g., entire ovary, ovarian cortex, and transplantation with tissue‐engineered products) can be applied to enhance the efficacy of artificial ovarian transplantation. For the better application of artificial ovary, a deeper understanding of mechanical and biochemical properties of the ovary and folliculogenesis after cryopreservation, transplantation with or without scaffold, and development of sophisticated in vivo imaging techniques of transplanted artificial ovary need to precede its efficient clinical application.

show abstract

Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a GMP-Compliant Tissue-Engineered Medicine

Cited by 88 publications

References 41 publications

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Tracheal Replacement Using an In-Body Tissue-Engineered Collagenous Tube “BIOTUBE” with a Biodegradable Stent in a Beagle Model: A Preliminary Report on a New Technique

A new possibility in fertility preservation: The artificial ovary

Contact Info

Product

Resources

About