Molecular mapping of Zika spread

Worobey, Michael

doi:10.1038/nature22495

Cited by 16 publications

(12 citation statements)

References 11 publications

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“…Our findings highlight the potential value of establishing intensive, community-level respiratory virus surveillance architectures, such as the Seattle Flu Study, during a pre-pandemic period. The value of detecting cases early, before they have bloomed into an outbreak, cannot be overstated in a pandemic situation (27). Given that every delay in case detection reduces the feasibility of containment, it is also worth assessing the impact of lengthy delays in FDA approval of testing the Seattle Flu Study's stored samples for SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

The emergence of SARS-CoV-2 in Europe and the US

Worobey

Pekar

Larsen

et al. 2020

Preprint

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One sentence summary:Sustained SARS-CoV-2 transmission networks became established in Europe and the US several weeks later than previously estimated. Abstract:Accurate understanding of the global spread of emerging viruses is critically important for public health response and for anticipating and preventing future outbreaks. Here, we elucidate when, where and how the earliest sustained SARS-CoV-2 transmission networks became established in Europe and the United States (US). Our results refute prior findings erroneously linking cases in January 2020 with outbreaks that occurred weeks later. Instead, rapid interventions successfully prevented onward transmission of those early cases in Germany and Washington State. Other, later introductions of the virus from China to both Italy and Washington State founded the earliest sustained European and US transmission networks. Our analyses reveal an extended period of missed opportunity when intensive testing and contact tracing could have prevented SARS-CoV-2 from becoming established in the US and Europe.

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Section: Discussionmentioning

confidence: 99%

The emergence of SARS-CoV-2 in Europe and the US

Worobey

Pekar

Larsen

et al. 2020

Preprint

Self Cite

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“…More recently, evolutionary biologist Michael Worobey wrote: "Systematic pathogen surveillance is within our grasp, but is still undervalued and underfunded relative to the magnitude of the threat" (REF. 118). If we are to achieve the sequencing singularity -the moment at which pathogen, environmental and digital data streams are integrated into a global surveillance system -we require a community united behind a vision in which public health and the attendant data belong to the public and behind the idea that we are a better, healthier society when the public is able to access and benefit from the data being collected about us and the pathogens we share the planet with.…”

Section: Box 1 | the Global Alliance For Genomics And Health (Ga4gh) mentioning

confidence: 99%

Towards a genomics-informed, real-time, global pathogen surveillance system

2017

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The recent Ebola and Zika epidemics demonstrate the need for the continuous surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast, affordable sequencing of pathogen genomes - now a staple of the public health microbiology laboratory in well-resourced settings - can affect each of these areas. Coupling genomic diagnostics and epidemiology to innovative digital disease detection platforms raises the possibility of an open, global, digital pathogen surveillance system. When informed by a One Health approach, in which human, animal and environmental health are considered together, such a genomics-based system has profound potential to improve public health in settings lacking robust laboratory capacity.

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“…The first important study that examined the ZIKV-associated American outbreak was published in Science where Faria and colleagues dated the transmission to have occurred via a single introduction event from Pacific Islands between May and December of 2013 (Faria et al 2016). Three seminal studies were then subsequently published in the same issue of Nature in June of 2017 which delineated the transmission and evolution of ZIKV across the Americas (Faria et al 2017; Grubaugh et al 2017; Metsky et al 2017; Worobey 2017). Faria et al revealed that Bahia province in northeastern Brazil was the epicenter of the outbreak in the Americas, where ZIKV first became established and then subsequently disseminated nationally and internationally (Faria et al 2017).…”

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confidence: 99%

The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas

Carr

et al. 2019

Virol. Sin.

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Since first isolation in 1947 from the Zika forest in Uganda, Zika virus (ZIKV) has been principally known as a benign agent associated with sporadic human infections in a restricted number of African countries. However, during 2015–2016, an Asian lineage of ZIKV caused an unprecedentedly large outbreak in the Americas and sizeable numbers of exported cases across the globe. In this review, we critically appraise the recent advances in molecular epidemiological studies of ZIKV performed to date, and we highlight the pivotal role played by genomic surveillance in elucidating the origins, dissemination and evolution of the Asian lineage of ZIKV in Asia and in the Americas.

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Molecular mapping of Zika spread

Cited by 16 publications

References 11 publications

The emergence of SARS-CoV-2 in Europe and the US

The emergence of SARS-CoV-2 in Europe and the US

Towards a genomics-informed, real-time, global pathogen surveillance system

The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas

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