Beyond Body Mass Index: Using Anthropometric Measures and Body Composition Indicators to Assess Odds of an Endometriosis Diagnosis

Backonja, Uba; Hediger, Mary L.; Chen, Zhen; Lauver, Diane; Sun, Liping; Peterson, C. Matthew; Louis, Germaine M. Buck

doi:10.1089/jwh.2016.6128

Cited by 32 publications

(35 citation statements)

References 73 publications

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“…Linear regression using Brobust^standard errors were used to estimate the beta coefficients (β) with a 95% confidence interval (CI) and logistic regression models were used to estimate odds ratios (OR) with a 95% CI. The analysis was adjusted a priori for patient age, body mass index (BMI), race (white vs. non-white), and smoking history due to the known effect between these demographic characteristics and markers of ovarian reserve [16][17][18][19]. Each group was further subdivided into SART age groups for analysis of baseline AMH.…”

Section: Methodsmentioning

confidence: 99%

The effect of endometriosis on the antimüllerian hormone level in the infertile population

Romanski

Brady

Farland

et al. 2019

J Assist Reprod Genet

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Purpose To determine whether the presence of endometriosis in infertile women without prior ovarian surgery influences markers of ovarian reserve, AMH and FSH. Methods A retrospective cohort study included three groups of women who presented for IVF treatment at our tertiary care center from 04/27/2015 to 05/31/2017: women with endometriosis and prior ovarian surgery (EnSx), women with endometriosis without prior ovarian surgery (En), and women with a primary diagnosis of male factor infertility (MF; reference group). Results There were 671 patients that met inclusion criteria (78 EnSx, 60 En, and 533 MF). Compared to the MF group (3.6 ± 3.0), a lower mean AMH level (ng/mL) was observed in the EnSx group (2.5 ± 2.5; aβ − 1.21; 95% CI [− 1.79, −0.62]) and in the En group (2.5 ± 2.2; aβ − 1.11; 95% CI [− 1.68, − 0.54]). Both endometriosis groups had a statistically significantly higher proportion of patients with an AMH < 1 (EnSx, 24.4%; OR, 2.39 [95% CI, 1.31, 4.36]; En, 28.3%; OR, 2.67 [95% CI, 1.41, 5.08]) compared to the MF group (13.9%). The mean baseline FSH level (lU/L) was statistically significantly higher in both endometriosis groups (EnSx, 8.6 ± 4.3; β, 1.37 [95% CI, 0.39, 2.34]; En, 8.4 ± 3.7; β, 0.96 [95% CI, 0.04, 1.87]) compared to the MF group (7.3 ± 2.2). Conclusions Among infertility patients with endometriosis, with and without a history of ovarian surgery, ovarian reserve markers were worse (lower AMH and higher FSH) and a higher proportion had decreased ovarian reserve as measured by AMH compared to women with MF.

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Section: Methodsmentioning

confidence: 99%

The effect of endometriosis on the antimüllerian hormone level in the infertile population

Romanski

Brady

Farland

et al. 2019

J Assist Reprod Genet

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“…Endometriosis is a dynamic and complex disorder, involving the interplay of genetic and environmental factors. The current review revealed a number of risk factors for endometriosis, including early menarche,[43] increased BMI,[444546] environmental factors (including cigarette smoking),[47] and genetic factors. [4849] It seems some of our findings were consistent with other studies that early menarche, shorter menstrual length, duration of infertility, and family history of endometriosis are strongly associated with endometriosis,[85051] while higher parity and higher BMI are associated with decreased risk.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have also suggested that women with a low BMI are at greater risk of endometriosis. [8444546] This might explain the difference in the prevalence in Asian women compared to women from the United States,[11] given that average BMIs are much higher in the US population. However, a critical question is whether the low BMI is the cause or the consequence of developing endometriosis even though these studies suggested a correlation.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic factors associated with endometriosis in East Asia

Yen

Kim

Lee

2019

Gynecol Minim Invasive Ther

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Aim:With a perplexing pathogenesis and an incidence rate of approximately 10% among women of reproductive age, endometriosis affects more women in Asia than in any other continent in the world. This paper reviews the available data on the epidemiology and risk factors associated with endometriosis in East Asia.Methods:Included studies were published between January 2000 and December 2016. Articles were required to include East Asian patients with a diagnosis of endometriosis and to study epidemiology, such as the prevalence and/or incidence, associated with inherited, environmental, and/or lifestyle factors. A total of 65 candidate articles were retrieved and 22 were included in the final review.Results:Only one study provided an estimate of prevalence (6.8%). Short menstrual cycle, family history of endometriosis, and some genetic polymorphisms are associated with the risk of developing endometriosis. Smoking, lower body mass index, and lower parity associated with increased risk of endometriosis were suggested as modifiable factors. Limitations of this study include the poor quality of data identified, and the language barriers behind the study retrieval.Conclusions:Data on the epidemiology of endometriosis in the East Asian populations are limited. The available data that examine potential genetic factors do not unveil whether such factors directly contribute to the increased risk of endometriosis. Further extensive studies on endometriosis in Asian women are required to improve the management of this disease.

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“…ENDO is inversely associated with BMI across the life course and with more favorable morphometric indicators and body composition (Backonja et al 2017, Farland et al 2017. Specifically, lower BMI is suggested to constitute a risk factor for the development of ENDO and a predictive factor for severe ENDO.…”

Section: Predisposition and Body Mass Indexmentioning

confidence: 97%

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Simmen

Brown

Quick

et al. 2019

Journal of Endocrinology

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Type 1 diabetes mellitus and endometriosis separately affect millions of women worldwide. Reproductive-age women diagnosed with type 1 diabetes may also suffer from endometriosis, but the asymptomatic pre-clinical period of highly variable duration for each condition can lead to challenges in the timely recognition of co-morbid disease onset and misdiagnosis. While knowledge of the pathogenesis of each condition has grown substantially, co-morbid endometriosis and type 1 diabetes has not been widely considered and much less addressed. This review discusses the molecular rationale for the likelihood of their co-existence, and prospects for improvements in therapeutic strategies and reduced complications, if this paradigm is included as a significant variable in disease management.

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Beyond Body Mass Index: Using Anthropometric Measures and Body Composition Indicators to Assess Odds of an Endometriosis Diagnosis

Abstract: In a surgical cohort, endometriosis was inversely associated with anthropometric measures and body composition indicators.

Cited by 32 publications

References 73 publications

The effect of endometriosis on the antimüllerian hormone level in the infertile population

The effect of endometriosis on the antimüllerian hormone level in the infertile population

Epidemiologic factors associated with endometriosis in East Asia

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

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