Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

Andino-Pavlovsky, Victoria; Souza, Annie C.; Scheffer-Teixeira, Robson; Tort, Adriano Bretanha Lopes; Etchenique, Roberto; Ribeiro, Sidarta

doi:10.3389/fncir.2017.00029

Cited by 38 publications

(35 citation statements)

References 64 publications

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“…More generally, these physiological oscillations are considered to be fundamental to the relation of brain structure and function 20 . Phase-amplitude coupling of delta/beta and theta/gamma oscillations has also been reported in motor and somatosensory cortices of rodents 94,59,144,4 and primates 118,32,90 . Cross-frequency coupling may help integrate information across temporal scales and across networks 21 .…”

Section: Emergence Of Physiological Oscillations and Phase-amplitude mentioning

confidence: 76%

Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit

Durá-Bernal

Neymotin

Suter

et al. 2017

Preprint

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We developed a biologically detailed multiscale model of mouse primary motor cortex (M1) microcircuits, incorporating data from several recent experimental studies. The model simulates at scale a cylindrical volume with a diameter of 300 m and cortical depth 1350 m of M1. It includes over 10,000 cells distributed across cortical layers based on measured cell densities, with close to 30 million synaptic connections. Neuron models were optimized to reproduce electrophysiological properties of major classes of M1 neurons. Layer 5 corticospinal and corticostriatal neuron morphologies with 700+ compartments reproduced cell 3D reconstructions, and their ionic channel distributions were optimized within experimental constraints to reproduce in vitro recordings. The network was driven by the main long-range inputs to M1: posterior nucleus (PO) and ventrolateral (VL) thalamus PO, primary and secondary somatosensory cortices (S1, S2), contralateral M1, secondary motor cortex (M2), and orbital cortex (OC). The network local and long-range connections depended on pre-and post-synaptic cell class and cortical depth. Data was based on optogenetic circuit mapping studies which determined that connection strengths vary within layer as a function of the neuron's cortical depth. The synaptic input distribution across cell dendritic trees -likely to subserve important neural coding functions -was also mapped using optogenetic methods and incorporated into the model. We employed the model to study the effect on M1 of increased activity from each of the long-range inputs, and of different levels of H-current in pyramidal tract-projecting (PT) corticospinal neurons. Microcircuit dynamics and information flow were quantified using firing rates, oscillations, and information transfer measures (Spectral Granger causality). We evaluated the response to short pulses and long time-varying activity arising from the different long-range inputs. We also studied the interaction between two simultaneous long-range inputs. Simulation results support the hypothesis that M1 operates along a continuum of modes characterized by the degree of activation of intratelencephalic (IT), corticothalamic (CT) and PT neurons. The particular subset of M1 neurons targeted by different long-range inputs and the level of H-current in PT neurons regulated the different modes. Downregulation of H-current facilitated synaptic integration of inputs and increased PT output activity. Therefore, VL, cM1 and M2 inputs with downregulated H-current promoted an PT-predominant mode; whereas PO, S11 . CC-BY-NC-ND 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/201707 doi: bioRxiv preprint first posted online Oct. 11, 2017; and S2 inputs with upregulated H-current favored an IT-predominant mode, but a mixed mode where upper layer IT cells in turn activated PT cells if H-c...

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Section: Emergence Of Physiological Oscillations and Phase-amplitude mentioning

confidence: 76%

Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit

Durá-Bernal

Neymotin

Suter

et al. 2017

Preprint

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“…The mPFC has direct projections from the hippocampus and works with the neural information coming from the hippocampus to perform its functions [14]. Previous studies show a dominant delta oscillation in mPFC which is modulated by task demand [15] and also by the activity in the hippocampus [16]. However, the exact mechanisms in which they communicate are not yet fully understood.…”

Section: Delta and Gamma Oscillations In Medial Pre-frontal Cortexmentioning

confidence: 99%

Gamma band oscillations drives information flow in theta and delta band between hippocampus and medial pre-frontal cortex

Samuel

2019

Preprint

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Information flow in the brain is mediated by neuronal oscillations. Prior research has shown that gamma activity considered to be most reflective of neuronal firing is nested within theta cycles. This finding has given rise to the notion that theta phase mediates the gamma oscillations and thereby paces information flow. Such findings have been observed predominantly in cases where the gamma and theta oscillations were measured from the same underlying neuronal substrate. In this article, we analyze the across region, inter-brain coupling of gamma and theta oscillations using non-directional and directional connectivity measures. We show that in this context the information flow appears to be mediated by gamma oscillations which in turn drives the theta and delta oscillations. Additionally, different bands of gamma are coupled with theta and delta bands. During task, this information flow is enhanced compared to baseline in the frequencies which are coupled. Furthermore, the connectivity measures namely cross-frequency coupling and generalized partial directed coupling are not correlated with each other suggesting that they maybe representative of different underlying neuronal mechanisms.

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“…Indeed, it was previously shown that ketamine could affect CFC between theta and gamma oscillations in the hippocampus of freely moving rats 51 . In contrast, delta-gamma CFC has been described in corticostriatal network and could reflect cortico-mesolimbic connectivity 55 , induced in frontal regions by anesthetic doses of ketamine 56 and modulated by dopaminergic activation 57,58 . One possible mechanism by which KET produces an enhancement in CFC is by increasing extracellular levels of dopamine.…”

Section: Discussionmentioning

confidence: 98%

Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

Lopes-Aguiar

Ruggiero

Rossignoli

et al. 2019

Preprint

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ABSTRACTN-methyl-D-aspartate receptor (NMDAr) antagonists such as ketamine (KET) produce psychotic-like behavior in both humans and animal models. NMDAr hypofunction affects normal oscillatory dynamics and synaptic plasticity in key brain regions related with schizophrenia, particularly in the hippocampus and the prefrontal cortex. In contrast, long-term potentiation (LTP) induction is known to increase glutamatergic transmission. Thus, we hypothesized that LTP could mitigate the electrophysiological changes promoted by KET. We recorded HPC-PFC local field potentials and evoked responses in urethane anesthetized rats, before and after KET administration, preceded or not by LTP induction. Our results show that KET promotes an aberrant delta-high-gamma crossfrequency coupling in the PFC and an enhancement in HPC-PFC evoked responses. LTP induction prior to KET attenuates changes in synaptic efficiency and prevents the increase in cortical gamma amplitude comodulation. These findings are consistent with evidence that increased efficiency of glutamatergic receptors attenuates cognitive impairment in animal models of psychosis. Therefore, high-frequency stimulation in HPC may be a useful tool to better understand how to prevent NMDAr hypofunction effects on synaptic plasticity and oscillatory coordination in cortico-limbic circuits.

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Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

Cited by 38 publications

References 64 publications

Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit

Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit

Gamma band oscillations drives information flow in theta and delta band between hippocampus and medial pre-frontal cortex

Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

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