Mismatch negativity (MMN) to spatial deviants and behavioral spatial discrimination ability in the etiology of auditory verbal hallucinations and thought disorder in schizophrenia

Perrin, Mary; Kantrowitz, Joshua T.; Silipo, Gail; Dias, Elisa C.; Jabado, Omar; Javitt, Daniel C.

doi:10.1016/j.schres.2017.05.012

Cited by 27 publications

(18 citation statements)

References 72 publications

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“…Our results are in line with other studies reporting attenuated duration- but not frequency deviant MMN peak amplitude in the early stages of schizophrenia (Näätänen and Kähkönen, 2009; Nagai et al, 2013). The finding of attenuated MMN in the auditory cortex is in line with other studies reporting reduced activation of the right (Fulham et al, 2014; Perrin et al, 2017) or left (Solís-Vivanco et al, 2014) auditory cortex in schizophrenia patients during MMN generation.…”

Section: Discussionsupporting

confidence: 92%

Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method

Randau

Oranje

Miyakoshi

et al. 2019

NeuroImage: Clinical

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Background Mismatch negativity (MMN) is a measure of pre-attentive auditory information processing related to change detection. Traditional scalp-level EEG methods consistently find attenuated MMN in patients with chronic but not first-episode schizophrenia. In the current paper, we use a source-resolved method to assess MMN and hypothesize that more subtle changes can be identified with this analysis method. Method Fifty-six first-episode antipsychotic-naïve schizophrenia (FEANS) patients (31 males, 25 females, mean age 24.6) and 64 matched controls (37 males, 27 females, mean age 24.8) were assessed for duration-, frequency- and combined-type MMN and P3a as well as 4 clinical, 3 cognitive and 3 psychopathological measures. To evaluate and correlate MMN at source-level, independent component analysis (ICA) was applied to the continuous EEG data to derive equivalent current dipoles which were clustered into 19 clusters based on cortical location. Results No scalp channel group MMN or P3a amplitude differences were found. Of the localized clusters, several were in or near brain areas previously suggested to be involved in the MMN response, including frontal and anterior cingulate cortices and superior temporal and inferior frontal gyri. For duration deviants, MMN was attenuated at the right superior temporal gyrus in patients compared to healthy controls ( p = 0.01), as was P3a at the superior frontal cortex (p = 0.01). No individual patient correlations with clinical, cognitive, or psychopathological measures survived correction for multiple comparisons. Conclusion Attenuated source-localized MMN and P3a peak contributions can be identified in FEANS patients using a method based on independent component analysis (ICA). This indicates that deficits in pre-attentive auditory information processing are present at this early stage of schizophrenia and are not the result of disease chronicity or medication. This is to our knowledge the first study on FEANS patients using this more detailed method.

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Section: Discussionsupporting

confidence: 92%

Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method

Randau

Oranje

Miyakoshi

et al. 2019

NeuroImage: Clinical

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“…The frontal and temporal lobes may thus be bilaterally involved in SCZ. In contrast to research reports of right- 15 or leftward 39 bias in the sensorium, some findings pointed to a lack of asymmetry in MMN 40 or P3 16,20,41 responses to dichotic stimuli. These inconsistent results may have stemmed from differences in patient samples among different laboratories 42–44 .…”

Section: Discussioncontrasting

confidence: 96%

“…Neuroimaging and post-mortem studies found that SCZ patients exhibit structural changes in auditory regions, particularly the STG 13 , and research on auditory event-related potentials (ERPs) provided strong evidence of cortical processing dysfunctions in SCZ subjects 14,15 . In one ERP investigation, for example, SCZ patients less accurately determined the location of a sound source than did healthy controls 16 .…”

Section: Introductionmentioning

confidence: 98%

Symmetrical electrophysiological brain responses to unilateral and bilateral auditory stimuli suggest disrupted spatial processing in schizophrenia

Sardari

Pourrahimi

Talebi

et al. 2019

Sci Rep

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Research has found auditory spatial processing deficits in patients with schizophrenia (SCZ), but no study has examined SCZ patients’ auditory spatial processing at both pre-attentional and attentional stages. To address this gap, we investigated schizophrenics’ brain responses to sounds originating from different locations (right, left, and bilateral sources). The event-related potentials (ERPs) of 25 chronic schizophrenic patients and 25 healthy subjects were compared. Mismatch negativity (MMN) in response to frequency and duration deviants was assessed. Two P3 components (P3a and P3b) were elicited via a frequency discrimination task, and MMN and P3 were recorded through separate monaural and dichotic stimulation paradigms. Our results corroborated the previously published finding that MMN, P3a, and P3b amplitudes are reduced in SCZ patients, but they showed no significant effect of stimulus location on either MMN or P3. These results indicated similarity between the SCZ patients and healthy individuals as regards patterns of ERP responses to stimuli that come from different directions. No evidence of auditory hemispatial bias in the SCZ patients was found, supporting the existence of non-lateralized spatial processing deficits in such patients and suggesting compensatory changes in the hemispheric laterality of patients’ brains.

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“…Previous studies also found that there was a significant correlation between MMN and some behavioral performance scores (75) and symptoms of schizophrenia (76), which might indicate that IGD did share some cognitive neurological characteristics with certain mental disorders. Accordingly, researchers attempted to use MMN as a diagnostic indicator in clinical practice (77), such as assisting in diagnosis of schizophrenia (78), which implied that MMN might also be one of the clinical diagnostic indicators of IGD.…”

Section: Discussionmentioning

confidence: 99%

Automatic Processing Advantage of Cartoon Face in Internet Gaming Disorder: Evidence From P100, N170, P200, and MMN

Zheng

Fan

et al. 2019

Front. Psychiatry

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Individuals with Internet gaming disorder (IGD) show deficits in face processing due to long-term Internet-game social activities based on cartoon faces in the popular online game "Strike of Kings." However, the abnormal neurocognitive mechanism of face recognition and processing in individuals with IGD has not been systematically explored. This study used event-related potential (ERP) methods and the reversed deviant-standard oddball paradigm to comprehensively compare four ERP components, namely, P100, N170, P200, and mismatch negativity (MMN), induced in the unconscious and automatic processing of realistic and cartoon faces in individuals with IGD. Results showed that, with respect to cartoon faces, individuals with IGD exhibited not only P100, P200 and MMN enhancements but also the absence of the N170 dominance effect in the left hemisphere. Our results also demonstrated that individuals with IGD had the advantages of early automatic perception of cartoon faces and automatic detection of changes in "cartoon" features. This study enhances our understanding of the mechanism of IGD from the neurocognitive perspective and provides candidate electrophysiological indicators for the clinical diagnosis of IGD.

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Mismatch negativity (MMN) to spatial deviants and behavioral spatial discrimination ability in the etiology of auditory verbal hallucinations and thought disorder in schizophrenia

Cited by 27 publications

References 72 publications

Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method

Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method

Symmetrical electrophysiological brain responses to unilateral and bilateral auditory stimuli suggest disrupted spatial processing in schizophrenia

Automatic Processing Advantage of Cartoon Face in Internet Gaming Disorder: Evidence From P100, N170, P200, and MMN

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