A poly(2-hydroxyethyl methacrylate)-based resin improves the dentin remineralizing ability of calcium silicates

Taddei, Paola; Prati, Carlo; Gandolfi, Maria Giovanna

doi:10.1016/j.msec.2017.04.002

Cited by 13 publications

(22 citation statements)

References 58 publications

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“…The Ca/P ratio ranged between 1.27 ± 0.01 and 1.38 ± 0.03, see Figure 1c, Figure 2c, Figure 3c, Figure 4c, Figure 5d, and Table 4. The IR spectra of the SL samples showed bands typical of collagen and B-type carbonated apatite, see Figure 6, Figure 7, Figure 8, Figure 9 and Figure 10, at wavenumber values similar to those found for sound dentine [22,24].…”

Section: Resultssupporting

confidence: 67%

“…The IR spectra of all the treated dentine samples at T0 showed the weakening of the apatite bands, see Figure 6, Figure 7, Figure 8 and Figure 9; however, it must be observed that the apatite bands did not disappear. This behavior suggests that demineralization was only partial and took place at a lower depth than that corresponding to the ATR sampling (i.e., 2 µm), differing from our previous studies in which dentine samples were treated with 17% EDTA for 2 h [24]. This trend confirms that the application time of the solution is crucial in determining the decalcifying effect [15].…”

Section: Discussioncontrasting

confidence: 60%

“…All the treatments, with the exception of 1% EDTA, determined shifts in the collagen bands (i.e., Amide III, COO − modes and, in the case of 10% and 17% EDTA, also Amide II, see Figure 7, Figure 8 and Figure 9). The Amide bands, due to the repeating peptide unit of proteins, have been extensively used to study the secondary structure and conformational transitions of proteins; the observed changes suggest that the collagen network underwent a certain conformational rearrangement upon demineralization, although to a lower extent than that previously observed by treatment with 17% EDTA for a longer period (i.e., 2 h [24]). From this point of view, it is not surprising that the treatment with 1% EDTA (i.e., the lowest investigated concentration) did not induce any effect on collagen conformation, see Figure 6.…”

Section: Discussionmentioning

confidence: 99%

“…The intensities of IR absorption bands provide quantitative information about the sample contents, depending on the nature of the molecular bonds, their structure, and their environment [22]. Previous investigations have used IR spectroscopy to study dentine collagen mineralization [22,24,25,26] and useful spectroscopic markers have been identified to determine the changes in the apatite/collagen ratio [22,24].…”

Section: Introductionmentioning

confidence: 99%

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Demineralization, Collagen Modification and Remineralization Degree of Human Dentin after EDTA and Citric Acid Treatments

et al. 2018

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The aim of the study was to investigate the effects of several decalcifying agents used as irrigant solutions in endodontic treatment on collagen and mineral components of dentin. Coronal dentin discs from five caries-free human third molars with a smear layer were treated for one minute with a chelating solution (1% Ethylenediaminetetraacetic acid (EDTA), 10% EDTA, 17% EDTA, 10% citric acid). Mineralization degree (Ca/N and P/N atomic ratios, IR Iapatite/Iamide II and I1410(carbonate)/I554(phosphate) spectroscopic ratios) and possible collagen rearrangements (collagen infrared (IR) amide II e III shifts) were evaluated by environmental scanning electron microscopy (ESEM)/energy dispersive X-ray spectroscopy (EDX) and IR spectroscopy before and after treatment (T0) and after ageing (T24h and T2m) in simulated body fluid (SBF). At T0, analysis showed that the highest demineralizing effect was achieved using a 10% citric acid solution and 10% EDTA, while the smallest effect was observed when using 17% EDTA. No significant collagen modifications were detected upon treatment with 1% EDTA, while subtle changes were observed after the other treatments. At T24h or T2m, analyses showed the highest remineralization values for 1% EDTA and the lowest for 10% citric acid, mainly at T2m. The samples treated with 17% EDTA showed slight collagen rearrangements upon remineralization. In conclusion, the highest demineralizing effect was observed for 10% EDTA and 10% citric acid. Collagen rearrangement was found for all the treatments except for 1% EDTA. The highest remineralization capability in SBF values was recorded for 1% EDTA and the lowest for 10% citric acid. A slight collagen rearrangement upon remineralization was still present in 17% EDTA-treated samples. Clinical use as a chelating agent in the endodontic therapy of citric acid and concentrated EDTA solutions should be reconsidered.

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Section: Resultssupporting

confidence: 67%

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Demineralization, Collagen Modification and Remineralization Degree of Human Dentin after EDTA and Citric Acid Treatments

et al. 2018

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“…The EDX analysis of the dentin surface differentiated the debris traces elements from AH Plus and gutta-percha (from Thermafil). EDX also offered the possibility to detect the composition of root dentin after irrigation procedures and their modification with respect to sound dentin [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Secondary Root Canal Treatment with Reciproc Blue and K-File: Radiographic and ESEM-EDX Analysis of Dentin and Root Canal Filling Remnants

Prati

Zamparini

Spinelli

et al. 2020

JCM

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Secondary root canal treatment requires the complete removal of filling materials with different chemical-physical properties. A newly developed single-use NiTi instrument (Reciproc Blue, RB) may be more effective in root canal retreatment. The aim of the present study was to evaluate morphology and composition of remnants after retreatment with RB compared to traditional K-File technique, in canals obturated with Thermafil/AH Plus. Twenty-four single-rooted human teeth were shaped with NiTi obturated with AH-Plus/Thermafil and retreated using RB NiTi instruments or manual K-Files. Radiographs were taken to evaluate endodontic space and radiopacity of residual filling-material before/after procedures. After retreatment, samples were longitudinally split and observed by environmental scanning electron microscopy connected to energy dispersive X-Ray spectroscopy (ESEM-EDX) to analyze the debris/remnant position, microchemistry, and dentinal surface morphology. Time for retreatments was recorded and compared using one-way ANOVA (p-value = 0.05). Radiopaque filling residuals were found in both groups. RB system resulted statistically faster than manual K-File in retreatment procedure (p < 0.001). Root canal space radiographic appearance obtained after retreatment with RB was wider than K-File (p < 0.05). ESEM-EDX revealed 4 different morphological dentin area. Area-1: debris-free with typical Ca, P, and N composition of dentin and detected in 70% of the surface. Area-2: presence of deproteinized smear layer free from N and debris in 15% of the surface. Area-3: a thick packed smear layer N-free and with fine debris consisting of trace elements from sealer in 10% of the surface. Area-4: packed with debris and trace elements. No difference was observed between both instruments regarding root canal space appearance and ESEM-EDX analysis. Both systems were able to remove filling material but created a dentine morphology composed of packed debris and filling materials embedded into the smear layer. Dentin surface composition resulted in collagen depleted by irrigation procedures. The reciprocating system required less time to complete retreatment.

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High water‐absorbent and fast‐expanding PMMA bone cement with double‐bridged structure

Chen

Tang

Zhao

et al. 2021

J of Applied Polymer Sci

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The volume shrinkage of polymethyl methacrylate (PMMA) bone cement has been solved by the expandable additives. However, the water absorption and swelling capacity of composite were not maximized as the rapid solidification of the cement and the poor connectivity of the additives in the matrix. In this study, the double-bridged structure was constructed in PMMA-based bone cement. Poly(methyl methacrylate-acrylic acid)-graphene oxide [P(MMA-AA)-GO] was synthesized by the dispersion polymerization, graphene oxide (GO) with sheet layer formed a bridging effect between the poly(methyl methacrylate-acrylic acid) [P(MMA-AA)], accelerating water absorption; hydroxyethyl methacrylate in the liquid formed capillary networks, which bridged all the expansion units, increasing the pathways of water transfer in the matrix. The double-bridged structure in the composite synergistically accelerated water absorption and swelling, causing complete water absorption and swelling performance before solidification, with maximum water absorption and swelling ratios of 125.2 ± 3.2% and 115.2 ± 4.7%, respectively. Surprisingly, the compressive strength of the composite had also been improved, and the maximum value was 78.3 ± 3.2 MPa, which satisfied the minimum compressive strength of acrylic implants in ISO 5833-2002 and ASTM F451-2016. This biomaterial exhibited a promising application prospect as its excellent expansion capacity and mechanical properties. K E Y W O R D S double-bridged structure, PMMA bone cement, solidification time, water absorption and expansion, water absorption rate 1 | INTRODUCTION Polymethyl methacrylate (PMMA) bone cement, as a rapid molding bone repair material, has been widely used in the clinical range of prosthetic joint fixation and repair of bone defects. 1-5 The molecular rearrangement occurring during polymerization produced a volumetric shrinkage of PMMA bone cement. 6-8 To address this problem, previous studies have focused on controlling the number of hydroxyl groups and the threedimensional network structure in the additives of the bone cement to eliminate shrinkage and impart swelling properties to the matrix. 9-13 However, the following problems have been found in the study of expandable bone cement: (a) The swelling capacity of expandable PMMA bone cement is considered to be not fully utilized as the

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A poly(2-hydroxyethyl methacrylate)-based resin improves the dentin remineralizing ability of calcium silicates

Cited by 13 publications

References 58 publications

Demineralization, Collagen Modification and Remineralization Degree of Human Dentin after EDTA and Citric Acid Treatments

Demineralization, Collagen Modification and Remineralization Degree of Human Dentin after EDTA and Citric Acid Treatments

Secondary Root Canal Treatment with Reciproc Blue and K-File: Radiographic and ESEM-EDX Analysis of Dentin and Root Canal Filling Remnants

High water‐absorbent and fast‐expanding PMMA bone cement with double‐bridged structure

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