Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)

Kim, Ji Won; Ha, Thi Kim Quy; Cho, Hyo-Moon; Kim, Eun‐Hee; Shim, Sang Hee; Yang, Jianmei; Oh, Won Keun

doi:10.1016/j.bmcl.2017.05.022

Cited by 26 publications

(24 citation statements)

References 31 publications

(13 reference statements)

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“…Usually, a more efficient or safer drug can be designed based on the original natural compound that exhibits the wanted activity. Kim et al (2017) designed and synthesized a series of escin derivatives without the angeloyl or tigloyl groups that are important for cytotoxicity of escins and modified glycosidic linkages by hydrolysis. Those Escin derivative showed lower cytotoxicity.…”

Section: Natural Products Inhibiting Sars-covmentioning

confidence: 99%

Current Prevention of COVID-19: Natural Products and Herbal Medicine

et al. 2020

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Starting from December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and unprecedented health crisis across the globe. While the development of cure is at full speed, less attention and fewer effort have been spent on the prevention of this rapidly spreading respiratory infectious disease. Although so far, several vaccine candidates have advanced into clinical trials, limited data have been released regarding the vaccine efficacy and safety in human, not mention the long-term effectiveness of those vaccines remain as open question yet. Natural products and herbal medicines have been historically used for acute respiratory infection and generally show acceptable toxicity. The favorable stability for oral formulation and ease of scaling up manufacture make it ideal candidate for prophylactic. Hereby, we summarized the most recent advance in SARS-CoV-2 prevention including vaccine development as well as experimental prophylactics. Mainly, we reviewed the natural products showing inhibitory effect on human coronavirus, and discussed the herbal medicines lately used for COVID-19, especially focused on the herbal products already approved by regulatory agency with identifiable patent number. We demonstrated that to fill in the response gap between appropriate treatment and commercially available vaccine, repurposing natural products and herbal medicines as prophylactic will be a vigorous approach to stop or at least slow down SARS-CoV-2 transmission. In the interest of public health, this will lend health officials better control on the current pandemic.

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Section: Natural Products Inhibiting Sars-covmentioning

confidence: 99%

Current Prevention of COVID-19: Natural Products and Herbal Medicine

et al. 2020

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“…154 It also has anticancer activity through intrinsic-mitochondrial apoptosis pathway by arresting G2/M and ROS generation. 155 The antiviral activity of escin has been reported against porcine epidemic diarrhea virus (PEDV), 156 HIV-1 157 and SARS-CoV. 158 Strong cytotoxicity of escins create a challenge for their drug development.…”

Section: Escinmentioning

confidence: 99%

“…159 However, SAR studies have shown that acylations at C-21 and C-22 with angeloyl or tigloyl groups were important for their cytotoxic effects. 156 Thus, escin derivatives with strong antiviral activities have been reported. 156 Moreover, it is an approved, well tolerated anti-edematous, anti-inflammatory drug.…”

Section: Escinmentioning

confidence: 99%

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Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Elufioye

Habtemariam

2020

TJNPR

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Coronaviruses (CoVs) are enveloped viruses that cause multiple respiratory and intestinal infections in humans and animals. 1 The term 'coronavirus' refers to the crown-like appearance of CoVs under electron microscope due to spike projections from the membrane. 2 These viruses were first described in the 1960s from patients with respiratory infections like the common cold. 3 Since then, several human coronaviruses (HCoVs) have been identified including the HCoV-Hong Kong University 1 (HKU1), HCoV-NL63; severe acute respiratory syndrome (SARS)-CoV; and Middle East respiratory syndrome (MERS)-CoV. 3 CoVs belong to the subfamilies Coronavirinae and Torovirinae of the family Coronaviridae in the order Nidovirales. 4 Based on phylogeny, they are divided into four genera as α-CoV, β-CoV, γ-CoV and δ-CoV. 5 The beta-CoV genus is further subdivided into four lineages (A, B, C, and D) 1 (Figure 1). Mammalian coronavirus include HCoV-229E and HCoV-NL63 which belong to the α-coronavirus class as well as HCoV-HKU1, SARS-CoV, MERS-CoV and HCoV-OC43 which are β-coronaviruses; while avian coronavirus is the γ-coronavirus and δ-coronavirus. 3 The novel coronavirus, 2019-nCoV, that caused the current global COVID-19 pandemic was first identified in December 2019 in the Wuhan region (Hubei Province) of China. Since then, the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses has formally designated the virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 6

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“…chekiangensis (Hu et Fang) Fang obtained various types of isolates, for example, triterpenoids (Yuan et al, 2013), flavonoids (Kapusta et al, 2007), coumarins (Niu et al, 2015) together with steroids (Zhang et al, 2009). Polyhydroxylated triterpenoid saponins, isolated from Aesculus genus (Wei et al, 2004;Kim et al, 2017) with great structural diversity, have been proved to be the major bioactive principles including anticancer (Patlolla et al, 2006), neuroprotective (Cheng et al, 2016), anti-inflammatory (Matsuda et al, 1997), antioxidative (Küçükkurt et al, 2010), and antiedematous activities (Piller, 1976). As part of our continuous research to screen cytotoxic and neuroprotective compounds of this type, a series of new triterpenoids (1-14) along with 19 reported analogs (15-33) from the seeds of Aesculus chinensis Bge.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Triterpenoid Saponins From the Seeds of Aesculus chinensis Bge. var. chekiangensis

et al. 2020

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Phytochemical investigation of Aesculus chinensis Bge. var. chekiangensis (Hu et Fang) Fang obtained 33 triterpenoid saponins, including 14 new ones, aesculiside C-P (1-14). The structure elucidations were performed through comprehensive MS, 1D and 2D-NMR analysis, and their absolute configuration was unambiguously determined by X-ray diffraction analysis as well as Mo 2 (OAc) 4-induced ECD method for the first time. All the substances were examined for their cytotoxic activities against three tumor cell lines, Hep G2, HCT-116, and MGC-803. Of these, compounds 8, 9, 14-16, 18, and 22 exhibited potent cytotoxicities against all cell lines with IC 50 of 2-21 µM, while compounds 3, 6, 7, 17-19, 20, 24, and 28 depicted moderate activity (IC 50 13 to >40 µM). On these bases, the preliminary structure-activity correlations were also discussed. Meanwhile the neuroprotective properties of triterpenoid saponins from Aesculus genus were evaluated for the first time. Among them, compounds 1, 4, 12, 20, 22, 25, 29, and 31 exhibited moderate activities against C O Cl 2-induced PC12 cell injury.

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Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)

Cited by 26 publications

References 31 publications

Current Prevention of COVID-19: Natural Products and Herbal Medicine

Current Prevention of COVID-19: Natural Products and Herbal Medicine

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Bioactive Triterpenoid Saponins From the Seeds of Aesculus chinensis Bge. var. chekiangensis

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