Molluscum Contagiosum: An Update

Leung, Alexander K C; Barankin, Benjamin; Hon, KL

doi:10.2174/1872213x11666170518114456

Cited by 68 publications

(77 citation statements)

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“…CTD has been a traditional medicine to cure warts and molluscum contagiosum caused by viral infections. Our study suggests that CTD can be further explored as an antifungal, antiviral, or antiprotozoan drug, utilizing its property of altering the ER-Golgi traffic system (8,15,74).…”

Section: Cantharidin Targets Gpi-anchor Remodelingmentioning

confidence: 96%

The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum

Sahu

Tomar

2019

Journal of Biological Chemistry

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Edited by Ursula Jakob Cantharidin (CTD) is a potent anticancer small molecule produced by several species of blister beetle. It has been a traditional medicine for the management of warts and tumors for many decades. CTD suppresses tumor growth by inducing apoptosis, cell cycle arrest, and DNA damage and inhibits protein phosphatase 2 phosphatase activator (PP2A) and protein phosphatase 1 (PP1). CTD also alters lipid homeostasis, cell wall integrity, endocytosis, adhesion, and invasion in yeast cells. In this study, we identified additional molecular targets of CTD using a Saccharomyces cerevisiae strain that expresses a cantharidin resistance gene (CRG1), encoding a SAM-dependent methyltransferase that methylates and inactivates CTD. We found that CTD specifically affects phosphatidylethanolamine (PE)-associated functions that can be rescued by supplementing the growth media with ethanolamine (ETA). CTD also perturbed endoplasmic reticulum (ER) homeostasis and cell wall integrity by altering the sorting of glycosylphosphatidylinositol (GPI)-anchored proteins. A CTD-dependent genetic interaction profile of CRG1 revealed that the activity of the lipid phosphatase cell division control protein 1 (Cdc1) in GPI-anchor remodeling is the key target of CTD, independently of PP2A and PP1 activities. Moreover, experiments with human cells further suggested that CTD functions through a conserved mechanism in higher eukaryotes. Altogether, we conclude that CTD induces cytotoxicity by targeting Cdc1 activity in GPI-anchor remodeling in the ER. Glycosylphosphatidylinositol (GPI) 3 anchor biosynthesis is an essential and conserved pathway in eukaryotes. GPI-anchor

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Section: Cantharidin Targets Gpi-anchor Remodelingmentioning

confidence: 96%

The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum

Sahu

Tomar

2019

Journal of Biological Chemistry

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“…A variety of treatment options are available, including watchful waiting (Leung & Davies, 2012). However, the literature on the efficacy of treatment of MC is very scarce and is based mainly on anecdotal evidence and open studies (Leung, Barankin, & Hon, 2017).…”

Section: Spontaneous Resolution Of the MC Lesions Is The Norm In Indimentioning

confidence: 99%

Glycolic acid cream for treatment of molluscum contagiosum

Dave¹,

Abdelmaksoud

2018

Dermatologic Therapy

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“…Similar clinical signals are verified in other animals infected by these viruses. Cases of human infections by some poxviruses, such as VACV, CPXV, and MPXV, have been constantly reported [ 3 , 26 , 28 , 35 , 51 ]. Differently, skin lesions related to CMLV have only been observed during the last few years, which opens important questions regarding the expanding host range of this virus [ 52 ].…”

Section: Introductionmentioning

confidence: 99%

Poxvirus Host Range Genes and Virus–Host Spectrum: A Critical Review

Oliveira

Rodrigues

Lima

et al. 2017

Viruses

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The Poxviridae family is comprised of double-stranded DNA viruses belonging to nucleocytoplasmic large DNA viruses (NCLDV). Among the NCLDV, poxviruses exhibit the widest known host range, which is likely observed because this viral family has been more heavily investigated. However, relative to each member of the Poxviridae family, the spectrum of the host is variable, where certain viruses can infect a large range of hosts, while others are restricted to only one host species. It has been suggested that the variability in host spectrum among poxviruses is linked with the presence or absence of some host range genes. Would it be possible to extrapolate the restriction of viral replication in a specific cell lineage to an animal, a far more complex organism? In this study, we compare and discuss the relationship between the host range of poxvirus species and the abundance/diversity of host range genes. We analyzed the sequences of 38 previously identified and putative homologs of poxvirus host range genes, and updated these data with deposited sequences of new poxvirus genomes. Overall, the term host range genes might not be the most appropriate for these genes, since no correlation between them and the viruses’ host spectrum was observed, and a change in nomenclature should be considered. Finally, we analyzed the evolutionary history of these genes, and reaffirmed the occurrence of horizontal gene transfer (HGT) for certain elements, as previously suggested. Considering the data presented in this study, it is not possible to associate the diversity of host range factors with the amount of hosts of known poxviruses, and this traditional nomenclature creates misunderstandings.

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Molluscum Contagiosum: An Update

Cited by 68 publications

References 0 publications

The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum

The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum

Glycolic acid cream for treatment of molluscum contagiosum

Poxvirus Host Range Genes and Virus–Host Spectrum: A Critical Review

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