Influence of delayed gadolinium enhanced MRI of cartilage (dGEMRIC) protocol on T2-mapping: is it possible to comprehensively assess knee cartilage composition in one post-contrast MR examination at 3 Tesla?

Verschueren, Joost; Tiel, Jasper van; Reijman, Max; Bron, Esther E.; Klein, Stefan; Verhaar, Jan A N; Bierma-Zeinstra, Sita M A; Krestin, Gabriël P.; Wielopolski, Piotr A.; Oei, Edwin H.G.

doi:10.1016/j.joca.2017.05.005

Cited by 5 publications

(9 citation statements)

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“…The predominant effect of GCM is on T1 times but it also affects T2 times . Nevertheless, this has minimal influence on concurrent dGEMRIC signal . The combination of T2 mapping and dGEMRIC provides a more comprehensive biochemical assessment of articular cartilage than either method alone .…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Nelson

Kawcak

Barrett

et al. 2018

Equine Veterinary Journal

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Articular cartilage is a critical joint tissue and its evaluation remains a diagnostic challenge in horses. Coupled with a poor capacity for healing, early degenerative changes in articular cartilage are difficult to characterise using routine diagnostic imaging evaluations. Both computed tomography (CT) and magnetic resonance imaging (MRI) provide volumetric joint assessment and highlight morphological and quantitative properties of articular cartilage, improving assessment of this essential tissue. While the use of CT and MRI for joint evaluation is not new, there still remains a shortage of literature and scientific studies on the ability of these methods to evaluate articular cartilage in the horse. This review article summarises current CT and MRI techniques capable of characterising equine articular cartilage, highlights recent advances in these techniques and discusses the numerous methods studied in human subjects that have been minimally investigated in horses. Imaging techniques are presented in terms of their capabilities of offering morphological and quantitative evaluation along with a discussion of their benefits and limitations. Finally, it summarises the current state-of-the-art approaches and identifies unmet clinical imaging needs to propel the advancement of articular cartilage and joint imaging in the horse.

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Nelson

Kawcak

Barrett

et al. 2018

Equine Veterinary Journal

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“…Femur cartilage was further divided into non‐weight bearing and weight bearing areas. Weight bearing area was defined as the cartilage within the outer perimeters of the menisci 22 . The MFC was divided into weight bearing central MFC (cMFC) and non‐weight bearing posterior MFC (pMFC).…”

Section: Methodsmentioning

confidence: 99%

“…Weight bearing area was defined as the cartilage within the outer perimeters of the menisci. 22 The MFC was divided into weight bearing central MFC (cMFC) and non-weight bearing posterior MFC (pMFC). The LFC was divided into nonweight bearing anterior LFC (aLFC), weight bearing central LFC (cLFC) and non-weight bearing posterior LFC (pLFC) (Fig.…”

Section: Mri Analysismentioning

confidence: 99%

Comparing the Effect of Mechanical Loading on Deep and Superficial Cartilage Using Quantitative UTE MRI

Wang,

Li,

et al. 2023

Magnetic Resonance Imaging

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BackgroundThe biomechanical properties of deep and superficial cartilage may be different, yet in vivo MRI validation is required.PurposeTo compare the effect of mechanical loading on deep and superficial cartilage in young healthy adults using ultrashort echo time (UTE)‐T2* mapping.Study TypeProspective, intervention.SubjectsThirty‐one healthy adults (54.8% females, median age = 23 years).Field Strength/Sequence3‐T, PD‐FS, and UTE sequences with four echo times (TEs = 0.1, 0.5, 2.8, and 4.0 msec; 0.6 mm isotropic spatial resolution) of the left knee, acquired before and after loading exercise.AssessmentQuantitative UTE‐T2* maps of the entire knee were generated using UTE images of four TEs. In deep and superficial cartilage of patella, medial and lateral femur, medial and lateral tibia cartilage (PC, MFC, LFC, MTC, and LTC), which were segmented manually, cartilage thickness and T2* values before and after loading were measured, extracted, taken averages of, and compared. Scan–rescan repeatability was evaluated. Body weight and body mass index (BMI) data were collected. Physical activity levels were evaluated using International Physical Activity Questionnaire.Statistical TestsPaired sample t‐tests, paired Wilcoxon Mann–Whitney tests, Pearson and Spearman correlation analyses, Kruskal–Wallis tests with post‐hoc Bonferroni correction. A P‐value <0.05 was considered statistically significant.ResultsThe scan–rescan repeatability was good (RMSA‐CV < 10%). After exercise, deep cartilage exhibited no significant differences in cartilage thickness (PPC = 0.576, PMTC = 0.991, PMFC = 0.899, PLTC = 0.861, PLFC = 0.290) and T2* values (PPC = 0.914, PMTC = 0.780, PMFC = 0.754, PLTC = 0.327, PLFC = 0.811), which both significantly decreased in superficial PC, MFC, LFC, and MTC. The T2* values of superficial MTC and deep MFC were moderately correlated with higher body weight (ρ = 0.431) and lower BMI (ρ = −0.499), respectively.Data ConclusionDeep and superficial cartilage may respond differently to mechanical loading as assessed by UTE‐T2*.Evidence Level2Technical EfficacyStage 3

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“…The equation calculated the percent change from pre- and post-joint loading activity means when data were not presented as percent change from baseline. A Taylor expansion equation [ 30 ] and a correlation coefficient (correlation = 0.9, derived from an included study with raw and percentage change data) [ 31 ], were used to estimate the standard deviation (SD) of the percentage change, as recommended in the Cochrane Handbook [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis

et al. 2023

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Background The impact of activity-related joint loading on cartilage is not clear. Abnormal loading is considered to be a mechanical driver of osteoarthritis (OA), yet moderate amounts of physical activity and rehabilitation exercise can have positive effects on articular cartilage. Our aim was to investigate the immediate effects of joint loading activities on knee and hip cartilage in healthy adults, as assessed using magnetic resonance imaging. We also investigated delayed effects of activities on healthy cartilage and the effects of activities on cartilage in adults with, or at risk of, OA. We explored the association of sex, age and loading duration with cartilage changes. Methods A systematic review of six databases identified studies assessing change in adult hip and knee cartilage using MRI within 48 h before and after application of a joint loading intervention/activity. Studies included adults with healthy cartilage or those with, or at risk of, OA. Joint loading activities included walking, hopping, cycling, weightbearing knee bends and simulated standing within the scanner. Risk of bias was assessed using the Newcastle–Ottawa Scale. Random-effects meta-analysis estimated the percentage change in compartment-specific cartilage thickness or volume and composition (T2 relaxation time) outcomes. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system evaluated certainty of evidence. Results Forty studies of 653 participants were included after screening 5159 retrieved studies. Knee cartilage thickness or volume decreased immediately following all loading activities investigating healthy adults; however, GRADE assessment indicated very low certainty evidence. Patellar cartilage thickness and volume reduced 5.0% (95% CI 3.5, 6.4, I2 = 89.3%) after body weight knee bends, and tibial cartilage composition (T2 relaxation time) decreased 5.1% (95% CI 3.7, 6.5, I2 = 0.0%) after simulated standing within the scanner. Hip cartilage data were insufficient for pooling. Secondary outcomes synthesised narratively suggest knee cartilage recovers within 30 min of walking and 90 min of 100 knee bends. We found contrasting effects of simulated standing and walking in adults with, or at risk of, OA. An increase of 10 knee bend repetitions was associated with 2% greater reduction in patellar thickness or volume. Conclusion There is very low certainty evidence that minimal knee cartilage thickness and volume and composition (T2 relaxation time) reductions (0–5%) occur after weightbearing knee bends, simulated standing, walking, hopping/jumping and cycling, and the impact of knee bends may be dose dependent. Our findings provide a framework of cartilage responses to loading in healthy adults which may have utility for clinicians when designing and prescribing rehabilitation programs and providing exercise advice.

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Influence of delayed gadolinium enhanced MRI of cartilage (dGEMRIC) protocol on T2-mapping: is it possible to comprehensively assess knee cartilage composition in one post-contrast MR examination at 3 Tesla?

Cited by 5 publications

References 14 publications

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Comparing the Effect of Mechanical Loading on Deep and Superficial Cartilage Using Quantitative UTE MRI

Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis

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