Profiles of Executive Function Across Children with Distinct Brain Disorders: Traumatic Brain Injury, Stroke, and Brain Tumor

Araujo, Gabriel C.; Antonini, Tanya N.; Anderson, Vicki; Vannatta, Kathryn; Salley, Christina G.; Bigler, Erin D.; Taylor, H. Gerry; Gerhardt, Cynthia A.; Rubin, Kenneth H.; Dennis, Maureen; Lo, Warren; Mackay, Mark T; Gordon, Anne; Koterba, Christine; Gomes, Alison; Greenham, Mardee; Yeates, Keith Owen

doi:10.1017/s1355617717000364

Cited by 26 publications

(15 citation statements)

References 61 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Headaches, seizures, neurocognitive impairments, and psychosocial disturbances are also reported in TBI survivors and may persist for years [ 13 ]. Neuropsychological sequelae are also noted in stroke survivors [ 14 ]. Many of these morbidities lead to impaired quality of life [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

If You Build It, They Will Come: Initial Experience with a Multi-Disciplinary Pediatric Neurocritical Care Follow-Up Clinic

2017

View full text Add to dashboard Cite

Pediatric Neurocritical Care diagnoses account for a large proportion of intensive care admissions. Critical care survivors suffer high rates of long-term morbidity, including physical disability, cognitive impairment, and psychosocial dysfunction. To address these morbidities in Pediatric Neurocritical Care survivors, collaboration between Pediatric Neurology and Pediatric Critical Care created a multidisciplinary follow-up clinic providing specialized evaluations after discharge. Clinic referrals apply to all Pediatric Neurocritical Care patients regardless of admission severity of illness. Here, we report an initial case series, which revealed a population that is heterogenous in age, ranging from 1 month to 18 years, and in diagnoses. Traumatic brain injuries of varying severity as well as neuroinfectious and inflammatory diseases accounted for the majority of referrals. Most patients (87%) seen in the clinic had morbidities identified, requiring ongoing evaluation and expansion of the clinic. Cognitive and psychological disturbance were seen in over half of patients at the initial clinic follow-up. Sleep disturbances, daytime fatigue, headache or chronic pain, and vision or hearing concerns were also common at initial follow-up. Data from this initial population of clinic patients reiterates the need for specialized follow-up care, but also highlights the difficulties related to providing this comprehensive care and evaluating interventions to improve outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

If You Build It, They Will Come: Initial Experience with a Multi-Disciplinary Pediatric Neurocritical Care Follow-Up Clinic

2017

View full text Add to dashboard Cite

show abstract

“…7,8,44 Studies have evaluated cognitive function in other PICU patients and select PNCC conditions like stroke and TBI. 10,19,33,45,46 PTSD in broad populations of PICU survivors has also been reported. 34,38 This project identified a need to expand outcomes research in PNCC to systematic measures of Social distress -Some of the relationships suffered because we couldn't maintain normal contact with people or go to birthday parties or just maintain some of those friendships -It was difficult to find people who were comfortable taking care of her.…”

Section: Discussionmentioning

confidence: 93%

Long-term Sequelae of Pediatric Neurocritical Care: The Parent Perspective

Williams

Eriksson

Piantino

et al. 2018

J Pediatr Intensive Care

View full text Add to dashboard Cite

Critical neurologic disease and injury affect thousands of children annually with survivors suffering high rates of chronic morbidities related directly to the illness and to critical care hospitalization. Postintensive care syndrome (PICS) in patients and families encompasses a variety of morbidities including physical, cognitive, emotional, and psychological impairments following critical care. We conducted a focus group study with parents of children surviving pediatric neurocritical care (PNCC) for traumatic brain injury, stroke, meningitis, or encephalitis to determine outcomes important to patients and families, identify barriers to care, and identify potential interventions to improve outcomes. Sixteen parents participated in four groups across Oregon. Three global themes were identified: (1) PNCC is an intense emotional experience for the whole family; (2) PNCC survivorship is a chronic illness; and (3) PNCC has a significant psychological and social impact. Survivors and their families suffer physical, emotional, psychological, cognitive, and social impairments for many years after discharge. Parents in this study highlighted the emotional and psychological distress in survivors and families after PNCC, in contrast to most PNCC research focusing on physical outcomes. Several barriers to care were identified with potential implications on survivor outcomes, including limited pediatric resources in rural settings, perceived lack of awareness of PICS among medical providers, and the substantial financial burden on families. Parents desire improved education surrounding PICS morbidities for families and medical providers, improved communication with primary care providers after discharge, access to educational materials for patients and families, direction to mental health providers, and family support groups to assist them in dealing with morbidities and accessing appropriate resources. Clinicians and researchers should consider the parent perspectives reported here when caring for and evaluating outcomes for children requiring PNCC.

show abstract

“…Those who were treated using radiotherapy performed less well than those who were not submitted to this therapy. Those who experienced only surgical resection performed better than those who went through any form of auxiliary treatment (ARAUJO et al, 2017), making evident the relationship between cognitive decline and the aggressiveness of cancer treatment.…”

Section: Results Obtained In the Analyzed Studiesmentioning

confidence: 98%

“…3.1 METHODS APPLIED IN THE ANALYZED STUDIESIn 2016, Krivtzky and colleagues conducted a retrospective cross-sectional study of 734 children aged 5-18 years and applied the Behavior Rating Inventory of Executive Functioning (BRIEF) to compare the EF of different clinical conditions in pediatrics and explore the influence the age of diagnosis and its evolution. The sample was divided into 5 clinical diagnosis groups: brain tumor, acute lymphoid leukemia (ALL), epilepsy (EPI), neurofibromatosis type 1 (NF1), and ornithine transcarbamylase deficiency (OTC-D); in addition to attention deficit hyperactivity disorder (ADHD) control group and the healthy control group.Likewise, other researchers have awakened interest in this same matter, however, on this occasion, opting to examine EF among brain dysfunctions children and the control group characterized by children without brain dysfunctions(ARAUJO et al, 2017).For Brazilian Journal of Health Review, Curitiba, v.4, n.3, p. 13759-13769 mar./apr. 2021 this purpose, 336 children were selected, diagnosed with the following pathologies: children with arterial ischemic cerebrovascular accident (n = 36; 6-16 years of age); traumatic brain injury (n = 82; 8-13 years of age); and brain tumor (n = 74; 9-18 years of age).…”

mentioning

confidence: 99%

Cognitive changes related to infratentorial brain neoplasms in pediatric patients / Mudanças cognitivas relacionadas a neoplasias cerebrais infratentoriais em pacientes pediátricos

Duarte¹,

Cavalcanti²,

Lopes³

2021

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

Cancer is a set of numerous diseases characterized by the abundant and disordered growth of cells. In the pediatric population, central nervous system tumors account for 20% of neoplasms. In this scenario, it is necessary to highlight that patients with tumors in the posterior fossa and aggressive treatments, such as exposure to cranial radiotherapy, have been associated with a decline in cognitive functioning. Thus, the main objective of this research was to evaluate, through theoretical and empirical studies of national and international literature, the cognitive impact on individuals with brain neoplasms in the posterior fossa region. To achieve this goal, the descriptors "brain neoplasms", "cognitive dysfunction" and "child development" were used in the LILACS-BVS, SciELO, and MEDLINE/PubMed databases, being considered as inclusion criteria articles published in the last five years (2016 -2020) and excluding articles whose methodology was inconsistent and bibliographic reviews; 4 articles were selected as a research sample. Based on the selected articles, it can be identified, in general, that the association between cognitive decline and infratentorial brain neoplasms is due to the form of treatment normally suggested to deal with this disease. Furthermore, a direct relationship was perceived between aggressive treatmentssuch as chemotherapy and radiotherapyand

show abstract

Profiles of Executive Function Across Children with Distinct Brain Disorders: Traumatic Brain Injury, Stroke, and Brain Tumor

Abstract: Results suggest that different childhood brain disorders result in distinct patterns of executive function deficits that differ from children without brain disorder. Implications for clinical practice and future research are discussed. (JINS, 2017, 23, 529-538).

Cited by 26 publications

References 61 publications

If You Build It, They Will Come: Initial Experience with a Multi-Disciplinary Pediatric Neurocritical Care Follow-Up Clinic

If You Build It, They Will Come: Initial Experience with a Multi-Disciplinary Pediatric Neurocritical Care Follow-Up Clinic

Long-term Sequelae of Pediatric Neurocritical Care: The Parent Perspective

Cognitive changes related to infratentorial brain neoplasms in pediatric patients / Mudanças cognitivas relacionadas a neoplasias cerebrais infratentoriais em pacientes pediátricos

Contact Info

Product

Resources

About