2850 Fecal Immunochemical Test in Asymptomatic People

Abstract

INTRODUCTION: Occult blood is strategy for colorectal cancer screening. The aim of this study is to analyze the value of quantitative monoclonal antibodies against human Hemoglobin for colonoscopy screening. METHODS: One hundred asymptomatic adult patients, aged over 40 up to 77, with no risky group, have had one sample of stool specimens collected for qualitative immunochromatography with monoclonal antibodies against human hemoglobin, following several days later by complete colonoscopy. Chi-square was used to compare proportional data whereas Student t test to compare means. P < 0.05 was considered significant. This was a prospective stufy, All patients signed the informed consent The author has no finantial disclosures. RESULTS: A total of 100 patients being 36 men aged 67 ± 7 and women 64 aged 65,5 ± 8 P > 0.05, distributed by age in patients with colon neoplasia and positve occult blood in stools, 67 ± 6 N1 = 20, with negative occult blood in stools with neoplasia aged 68 ± 6 N2 = 11, with positive occult blood in stools without neoplasia 65,5 ± 9 N3 = 21 and negative occult blood in stools withou neoplasia 64,5 ± 8 N4 = 48 P > 0.05.Thirty-one (31%) of the patients had diagnosisof colon neoplasia, being 20 (64%) with positive occult blood in stools and 11 (35%) negative, P < 0.01. In the Group with positive occult blood in stools, two patients had diagnosis of adenocarcinoma, the others were adenomas. In the Group of negative occult blood in stools all were adenomas. We had 69 patients without neoplasia, of whom 21 (30.5%) had positive occult blood in stools and 48 (69%) negative, P < 0.01. In this Group without neoplasia, 12 (17%) had an abnormal colonoscopy, 5 (41.5%) with positive occult blood in stools and 7 (58%) negative P > 0.05. Abnormalities without neoplasia in patients with or withou occult blood in stools were angiodysplasia in ascending colon, shallow ulcer in ileocecal valve or ascending colon in NSAID user and uncomplicated diverticular disease. CONCLUSION: The age of the Group studied was similar, Adenocarcinoma only occurred in patients with positive blood in stools. Adenoma was present in positive and negative, although significantly more frequent in the positive ones. For bether conclusion, we need a greater number of asymptomatic people to be studied. The ideal test would be one that diagnoses cancer for treatment and adenoma for endoscopic prevention.