Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

Huang, Yong; Liu, Lidi; Liao, Qinyu; Zhang, Shaokun

doi:10.3340/jkns.2015.0708.010

Cited by 12 publications

(14 citation statements)

References 8 publications

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“…Patients with these tumors are often asymptomatic and are incidentally detected on imaging for other purposes in late childhood [2] . Although benign and often asymptomatic, intrathoracic GN may grow aggressively compressing vital structures such as the spinal cord and tracheobronchial tree leading to neurologic and respiratory symptoms [3] , [4] 5] . The CT appearance of a GN is usually nonspecific, however the differential diagnosis tends to be limited to other neuroblastic tumors given their characteristic location.…”

Section: Introductionmentioning

confidence: 99%

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Brock

Sharma

Villada

et al. 2021

Radiology Case Reports

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Ganglioneuromas (GN) are rare, mature tumors that arise in the posterior mediastinum or retroperitoneum from neural crest cells and present as slow growing masses in the pediatric population. While they are often found incidentally in unrelated diagnostic workup, they can become symptomatic due to their size and location. They typically demonstrate the nonspecific appearance of a solid mass without invasive or destructive features across different modalities. Such features are normally indicative of more aggressive neoplasms from similar cellular ancestry or an entirely different lineage. Here we present a case of mediastinal GN that on imaging was initially suggestive of an osteochondroma with malignant degeneration based on the presence of an exostosis associated with a large solid mass. Final pathology, however, revealed GN with involvement of the adjacent bone. While the final diagnosis was benign, it is important to recognize this pattern of exostosis with solid mass, especially since the overall survival rate of sarcomata is much worse than that of a classic GN.

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Section: Introductionmentioning

confidence: 99%

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Brock

Sharma

Villada

et al. 2021

Radiology Case Reports

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“…Moreover, the required incision for the final in toto tumor removal from the abdominal cavity would render prior minimally invasive efforts futile. Preoperative diagnostic imaging and functional tests are mandatory to evaluate, for example, tumor vessel invasion like in our case [1], spinal cord invasion [18][19][20][21]32], or potential hormoneproducing tumors especially in retroperitoneal/adrenal Exact max. size unknown, but < 10 cm according to the provided imaging cases [2,[13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…Total resection, on the other hand, was performed in 10 out of 13 cases. In the remaining three cases, one was removed piecemeal in one procedure, whereas a second surgical approach was necessary in the remaining two cases [5,32]. Twelve out of 13 papers reported the absence of surgical complications or postoperative unexpected events.…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

et al. 2020

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Background Ganglioneuromas (GNs) are extremely rare, slowly growing, benign tumors that can arise from Schwann cells, ganglion cells, and neuronal or fibrous tissues. Due to their origin from the sympathetic neural crest, they show neuroendocrine potential; however, most are reported to be hormonally inactive. Nevertheless, complete surgical removal is recommended for symptom control or for the prevention of potential malignant degeneration. Case Report A 30-year-old female was referred to our oncologic center due to a giant retroperitoneal and mediastinal mass detected in computed tomography (CT) scans. The initial symptoms were transient nausea, diarrhea, and crampy abdominal pain. There was a positive family history including 5 first- and second-degree relatives. Presurgical biopsy revealed a benign ganglioneuroma. Total resection (TR) of a 35 × 25 × 25 cm, 2550-g tumor was obtained successfully via laparotomy combined with thoracotomy and partial incision of the diaphragm. Histopathological analysis confirmed the diagnosis. Surgically challenging aspects were the bilateral tumor invasion from the retroperitoneum into the mediastinum through the aortic hiatus with the need of a bilateral 2-cavity procedure, as well as the tumor-related displacement of the abdominal aorta, the mesenteric vessels, and the inferior vena cava. Due to their anatomic course through the tumor mass, the lumbar aortic vessels needed to be partially resected. Postoperative functioning was excellent without any sign of neurologic deficit. Conclusion Here, we present the largest case of a TR of a GN with retroperitoneal and mediastinal expansion. On review of the literature, this is the largest reported GN resected and was performed safely. Additionally, we present the first systematic literature review for large GN (> 10 cm) as well as for resected tumors growing from the abdominal cavity into the thoracic cavity.

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“…Paravertebral ganglioneuroma and scoliosis is rarer and has only been sporadically reported. There are 13 different articles dealing with ganglioneuroma and scoliosis [7][8][9][10][11][12][13][14][15][16][17]. There are three types of paravertebral ganglioneuroma and scoliosis: 1) The tumor grows e neuro-ectodermal origin [1].…”

Section: Discussionmentioning

confidence: 99%

Giant Thoracic Ganglioneuroma with Mass Effect: A Case Report

Zegmout¹,

Hanane²,

Abdelhalim³

et al. 2020

Int J Pediatr Res

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Thoracic ganglioneuromas are exceedingly rare. They arise from neural crest cells. These tumors are mostly asymptomatic, but massive tumors can present symptoms related to locoregional compression like dyspnea or scoliosis. We report a case of thoracic paravertebral giant ganglioneuroma in a 12-year-old child presenting as a large intrathoracic mass in the posterior mediastinum with intimate contact with the dorsal spine. That masse causes skeletal deformity and scoliosis. Scoliosis secondary to ganglioneuroma is rare and there is no report on its incidence. The diagnosis was made on a CT-guided tarnsparietal biopsy. Our intent is to highlighting the difficulties that may occur during the diagnosis of such patients, especially in view of the unusual clinical signs and the large size of the tumor. As well as the management of paravertebral ganglioneuroma associated with scoliosis, especially in the preoperative phase. CASE REpORTCheck for updates and analysis of the case improved the knowledge of this tumor. ObservationA 12-year-old child without a medical history significant, had been presented witha progressive shortness of breath without other respiratory or extra respiratory associated signs. The child had no loss of weight, and his appetite was good. The clinical examination objectified the presence of a scoliosis attitude and a condensation syndrome of the right hemithorax, there were no abnormalities on nervous system examination.A chest X -ray revealed a large round opacity occu-

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Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

Cited by 12 publications

References 8 publications

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

Giant Thoracic Ganglioneuroma with Mass Effect: A Case Report

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