Synthesis, structure elucidation and biological evaluation of triple bridged dinuclear copper(II) complexes as anticancer and antioxidant/anti-inflammatory agents

Boulsourani, Z.; Katsamakas, Sotirios; Geromichalos, George D.; Psycharis, Vassilis; Raptopoulou, Catherine P.; Hadjipavlou‐Litina, Dimitra; Yiannaki, E.; Dendrinou‐Samara, Catherine

doi:10.1016/j.msec.2017.03.157

Cited by 18 publications

(7 citation statements)

References 55 publications

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“…In the same way, the docking protocol was applied to [Cu(phen) 2 2+ , respectively) due to hindering shape effects related to the bulky nature of the ligands. These results, in analogy with previous docking studies performed on similar Cu(II) mixed complexes 39,43 , prompted us to explore the possibility that their inhibitory activity was a result of allostery. A cavity previously identified and located between the Cterminus and N-terminus domains of LOX-3 was chosen as potential binding site for the tested compounds.…”

Section: Molecular Dockingsupporting

confidence: 67%

The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties

et al. 2020

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Section: Molecular Dockingsupporting

confidence: 67%

The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties

et al. 2020

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“…The peak at δ 2.45 ppm as singlet due to methyl hydrogens of substituted benzothiazole ring. The proton signals obtained for Schiff base ligand were in expected region[17].The13 C NMR of the ligand L3 showing signals at 157 ppm of azomethine carbon and 146-120 ppm…”

mentioning

confidence: 85%

“…Copper(II) schiff base complexes have diverse biological activities such as antioxidant, anticancer, antiproliferative and many chemotherapeutic properties [13,14]. They shows different electrochemical properties depen ding upon moiety of the Schiff base ligand [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic characterization and DNA binding studies of Cu(II) complex of Schiff base containing benzothiazole moiety

Chaurasia

Tomar

Chandra

2019

Journal of Taibah University for Science

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A Schiff base ligand L has been synthesized by the condensation of thiophene-2-carbaldehyde and 2-amino-6-methylbenzothiazole. It has been characterized by elemental analysis, Infrared (IR), 1 H NMR and mass spectrometry. Copper (II) complex, ML 2 has been synthesized by the reacting ligand L and Copper (II) acetate in 2:1 molar ratio. The Cu(II) complex was characterized by elemental analysis, molar conductance, electronic spectrum, IR and electronic paramagnetic resonance spectrum. TGA has been done to check the thermal stablity of Cu(II) complex. Spectroscopic studies revealed that ligand L binds with the Cu(II) ion as bidentate fashion. On the basis of spectral studies, a distored octahedral geometry has been assigned for Cu(II) complexof ligand L. The DNA binding studies of Cu(II) complex ML 2 have been investigated by UV-vis absorption and fluorescence spectroscopy. The binding mode of ML 2 with CT-DNA could be assigned as intercalation of the metal complex between DNA base pairs.

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“…There is one bipyridine unit attached to each copper ion of the dimer or two bipyridine ligands attached to each copper ion . The former category contains diverse bridging groups between copper ions such as hydroxyl and water, carboxylate, chloro‐, or mixed bridging groups . Carboxylate moiety exhibits diverse coordination and bridging modes in copper carboxylate complexes.…”

Section: Introductionmentioning

confidence: 99%

Mononuclear vs. binuclear carboxylates of copper(II) with 2,2′‐bipyridine: Synthesis, characterization, structural description, and properties

Iqbal

Ali

Sohail³

et al. 2019

J Chinese Chemical Soc

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Two new copper(II) carboxylate complexes with 2,2′‐bipyridine and para‐nitrophenyl acetate (complex 1) and phenyl acetate (complex 2) have been synthesized; isolated in quantitative yield; and characterized using fourier‐transform infrared spectroscopy (FT‐IR), electron paramagnetic resonance, absorption spectroscopy, electrochemistry, and powder and single crystal X‐ray diffraction (XRD) techniques. Being mononuclear, the geometry around copper in complex 1 is a Jahn–Teller distorted octahedral, while complex 2 is binuclear with slightly distorted square pyramidal geometry around both copper ions. Powder XRD indicated several peaks in spectra of both complexes, which coincided with their theoretical spectra. FT‐IR results of the carboxylate stretching frequency were in accordance with the single crystal structure data. Electron paramagnetic resonance spectra of complexes 1 and 2 yielded g┴ values of 2.06161 and 2.24623 and 1.94959, respectively, indicating a localized electron in b1 (d x2–y2‐orbital). Ultra‐violet (UV)–visible spectroscopy and electrochemistry helped in characterization, as well as in deoxyribonucleic acid (DNA)‐binding ability of the complexes, yielding DNA‐binding constant values = 1.351 × 104 and 1.361 × 104 and 1.820 × 104 and 2.426 × 104 M−1, respectively, for complexes 1 and 2. The complexes demonstrate good biological potential.

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Synthesis, structure elucidation and biological evaluation of triple bridged dinuclear copper(II) complexes as anticancer and antioxidant/anti-inflammatory agents

Cited by 18 publications

References 55 publications

The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties

The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties

Synthesis, spectroscopic characterization and DNA binding studies of Cu(II) complex of Schiff base containing benzothiazole moiety

Mononuclear vs. binuclear carboxylates of copper(II) with 2,2′‐bipyridine: Synthesis, characterization, structural description, and properties

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