Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Abstract

Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials Article (Accepted Version) http://sro.sussex.ac.uk Mazidi, Mohsen, Karimi, Ehsan, Rezaie, Peyman and Ferns, Gordon A (2016) Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes and its Complications. ISSN 1056-8727 This version is available from Sussex Research Online: http://sro.sussex.ac.uk/61270/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. methods were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I 2 index. Random effects meta-regression was performed using unrestricted maximum likelihood method to evaluate the impact of potential moderator. ÔØ Å ÒÙ×Ö ÔØ A C C E P T E DInternational Prospective Register for Systematic Reviews (PROSPERO) number CRD42016036868.Results: Meta-analysis of the data from 7 treatment arms revealed a significant reduction in serum CRP concentrations following treatment with GLP-1 RAs (WMD -2.14 (mg/dL), 95% CI -3.51, -0.78, P=0.002; I 2 96.1%). Removal of one study in the meta-analysis did not change the result in the sensitivity analysis (WMD -2.14(mg/dL), 95% CI -3.51, -0.78, P=0.002; I 2 96.1%), indicating that our results could not be solel...

The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis

“…In brief, net changes in measurements (change scores) were calculated as follows: measure at end of follow-up - measure at baseline (20). Where standard error of the mean (SEM) was only reported, SD was estimated using the following formula: SD=SEM×square root ( n ), where n is the number of subjects (20).…”

“…In brief, net changes in measurements (change scores) were calculated as follows: measure at end of follow-up - measure at baseline (20). Where standard error of the mean (SEM) was only reported, SD was estimated using the following formula: SD=SEM×square root ( n ), where n is the number of subjects (20). If the outcome measures were reported as median and range (or 95% confidence interval (CI)], mean and standard SD values were estimated using the method described by Hozo et al (21).…”

“…If the outcome measures were reported as median and range (or 95% confidence interval (CI)], mean and standard SD values were estimated using the method described by Hozo et al (21). When the outcome variable was available only in the graphic form, the software GetData Graph Digitizer 2.24 (20) was used to digitize and extract the data. Blood lipid and glucose levels were collated in mmol/L; a multiplication factor of 0.0259, 0.0113, or 0.0555 was used to convert cholesterol (total cholesterol, HDL-C, or LDL-C), TGs, and glucose levels, respectively, from mg/dl to mmol/L as appropriate (20).…”

“…Heterogeneity was quantitatively assessed using I 2 index. I 2 values <50% and ≥50% corresponded with the use of fixed-effects and random-effects model, respectively (20). Effect sizes were expressed as weighed mean difference (WMD) and 95% CI.…”

“…Potential publication bias was explored using a visual inspection of Begg’s funnel plot asymmetry, Begg’s rank correlation, and Egger’s weighted regression tests (20). Duval and Tweedie’s ‘trim and fill’ and ‘fail-safe N’ methods were used to adjust the analysis for the effects of publication bias (26).…”