Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants

Bocca, Beatrice; Ciccarelli, Simona; Agostino, Rocco; Alimonti, Andrea

doi:10.1016/j.envres.2017.04.027

Cited by 22 publications

(15 citation statements)

References 66 publications

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“…Athletes presented inadequate dietary intake of antioxidant nutrients, such as vitamins A and E, in addition to the minerals zinc, copper and manganese [36]. This condition leads the athlete to a state of oxidative imbalance and may decrease the protective activity of antioxidant enzymes (superoxide dismutase, glutathione and catalase), which is caused mainly by the low intake of minerals (copper, zinc and manganese), which are considered enzyme binding cofactors responsible for the first-line defense in the antioxidant system, superoxide dismutase [51][52][53]. In this sense, due to the rich composition of vitamins [54], minerals [55] and polyphenolic compounds [56,57], the grape juice may have momentarily adjusted the athletes' nutritional deficiency.…”

Section: Discussionmentioning

confidence: 99%

A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study

et al. 2019

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Purpose To investigate the effects of a single dose of juice on physical performance, oxidative stress, inflammation and muscle damage in runners. Methods Fourteen recreational male runners (39 ± 9 years, VO2peak = 55.9 ± 6.5 ml/kg/min) performed two running tests to exhaustion at 80% of VO2max after ingesting grape juice or a placebo drink (10 ml/kg/day) randomly. Blood samples were taken before and 2 h after supplementation and immediately after running to analyze total antioxidant capacity (TAC), malondialdehyde (MDA), alpha-1 acid glycoprotein (A1GPA), high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK) and lactate dehydrogenase (LDH). Results The participants ran for an average of 59.2 ± 27.8 min until exhaustion in the placebo group and for 68.4 ± 29.7 min until exhaustion in the grape juice intake group, which was a significantly longer time (p = 0.008). This improvement in physical performance was accompanied by a 43.6% increase in TAC (p = 0.000) at the post-exercise timepoint compared to the level at baseline. MDA, A1GPA, hs-CRP, CK, and LDH did not exhibit changes. In contrast, no significant change in any variable was observed after consuming the placebo drink. Conclusion The single-dose intake of purple grape juice demonstrated an ergogenic effect in recreational runners by increasing run time to exhaustion and increasing antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study

et al. 2019

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“…Mn is an essential nutrient and as such, is necessary for proper growth and development. 61,62 Further, it has been suggested that Mn may minimize free radical formation and protect against oxidative damage during pregnancy and thus fetal growth. 62 A positive association has been found between deciduous tooth Mn and birth weight.…”

Section: Discussionmentioning

confidence: 99%

“…61,62 Further, it has been suggested that Mn may minimize free radical formation and protect against oxidative damage during pregnancy and thus fetal growth. 62 A positive association has been found between deciduous tooth Mn and birth weight. 63 However, evidence suggests that Mn follows a U-shaped dose-response curve, and lower and higher maternal urine and blood Mn levels during pregnancy have been related to lower birth weight.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study

Signes-Pastor

Doherty

Romano

et al. 2019

Environmental Epidemiology

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Background: In utero exposure to individual metals may impact fetal growth, though little is known about the effects of exposure to metal mixtures. Therefore, we investigated joint effects of in utero exposure to a mixture of As (arsenic), Mn (manganese), and Pb (lead) on newborn outcomes in a United States population. Methods: Concentrations of As, Mn, and Pb were determined in maternal postpartum toenail samples, a biomarker of in utero exposure, from 989 maternal-infant pairs (492 females and 497 males). Newborns’ anthropometric characteristics, including head circumference, length, and weight, were obtained from medical records. The joint effects of the three metals were modeled using Bayesian kernel machine regression and linear regression. Both sex-combined and sex-stratified statistical analyses were performed. Results: We observed an inverted-U-shape association between maternal toenail Mn concentrations and newborn head circumference, particularly among female infants. Concentrations of Pb were related to reduced head circumference, weight, and length, especially among females at lower concentrations of the other metals. Overall, toenail As concentrations were related to reduced head circumference, especially among males, and an increase in birth length and weight among females. We found little evidence of As interactions with other metals within the mixture. Conclusions: Our findings suggest that in utero metal mixture exposures may influence birth outcomes, and that such relations may differ by infant sex.

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“…This is likely due to a combination of factors including ischemia-reperfusion injury, systemic inflammatory response, fluid shifts in body compartments, and a host of other physiologic responses to injury or disease. Many neonatal diseases and complications, such as respiratory distress syndrome, necrotizing enterocolitis (NEC), chronic lung disease, ROP, and intraventricular hemorrhage are related to increased oxidative stress as well [ 93 ]. However, there are mixed reports of vitamin E status in critical illness.…”

Section: Fat Soluble Vitaminsmentioning

confidence: 99%

Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

et al. 2017

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Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve many functions in metabolism. Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake. Determination of micronutrient status, especially in children, usually relies on a combination of biomarkers, with only a few having been established as a gold standard. Almost all micronutrients display a decrease in their serum levels in critically ill children, resulting in an increased risk of deficiency in this setting. While vitamin D deficiency is a well-known phenomenon in critical illness and can predict a higher need for intensive care, serum concentrations of many trace elements such as iron, zinc, and selenium decrease as a result of tissue redistribution in response to systemic inflammation. Despite a decrease in their levels, supplementation of micronutrients during times of severe illness has not demonstrated clear benefits in either survival advantage or reduction of adverse outcomes. For many micronutrients, the lack of large and randomized studies remains a major hindrance to critically evaluating their status and clinical significance.

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Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants

Cited by 22 publications

References 66 publications

A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study

A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study

Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study

Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

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