Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

Ribeiro, Daniel Araki; Yujra, Veronica Quispe; Silva, Victor Hugo Pereira da; Cláudio, Samuel Rangel; Estadella, Débora; Viana, Milena de Barros; Oshima, Celina Tizuko Fujiyama

doi:10.1007/s11356-017-9105-3

Cited by 31 publications

(22 citation statements)

References 44 publications

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“…Recent evidence in fish models indicated that high concentrations of fluoride can modify growth and development, induced pathologic bone deformity, and disrupt cell respiration and metabolism [15][16][17]. These events lead to an excessive production of reactive oxygen species (ROS) with resultant impairment of antioxidant system, DNA damage, mitochondrial dysfunction, and increased mortality rate [18,19].…”

Section: Introductionmentioning

confidence: 99%

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Ahmed

Sadek

Soliman

et al. 2020

Animals

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The potential antioxidant property of Moringa oleifera (MO) has been the recent focus of an increased number of studies. However few studies investigated its antioxidative ability against sodium fluoride-induced redox balance breakdown in Oreochromis niloticus. Thus, this study evaluates the effects of MO against the oxidative stress induced by sub-chronic exposure to sodium fluoride (NaF). A total of 264 fish (40 ± 3 g BW) were used to calculate the 96 hr-LC50 of NaF and perform the sub-chronic exposure study. 96 hr-LC50 of NaF was calculated as (61 mg/L). The 1/10 dose of the calculated 96 hr-LC50 (6.1 mg/L) was used to complete the sub chronic exposure for eight weeks. Fish were divided into four groups (n = 51; three replicates each); control, non-treated group; NaF group (exposed to NaF 6.1 mg/L); MO group (treated with 1% MO of diet); and NaF+MO (exposed to NaF 6.1 mg/L and treated with 1% MO of diet). The results revealed that the sub-chronic exposure to NaF (6.1 mg/L) was substantially increased malondialdehyde (MDA) and decrease the activities of superoxide dismutase (SOD), catalase (CAT), glutathione reduced (GSH), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) in the gills, liver, kidney, and muscle tissue in a time-dependent manner. In addition, a significant reduction in mRNA expression of GST in the liver was reported following NaF exposure. On the contrary, dietary supplementation of MO to NaF-exposed fish resulted in a significant reduction in MDA levels, and a significant elevation of SOD, CAT, GSH, GPx, and TAC activities in a time-dependent manner, in addition to significant elevation of GST mRNA expression in liver tissue. It could be concluded that a 1% MO (w/w) ration is a promising antioxidant plant that may successfully use to interfere with the oxidation processes induced by NaF in various tissues of Oreochromis niloticus.

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Section: Introductionmentioning

confidence: 99%

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Ahmed

Sadek

Soliman

et al. 2020

Animals

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“…Although fluoride is absorbed largely by the mineralized extracellular matrix in calcified tissues, absorbed fluoride can lead to mitochondrial dysfunction, DNA damage, and lipid peroxidation in cells through the production of reactive oxygen species (ROS) [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation

Miranda

Gomes

Bittencourt

et al. 2018

Oxidative Medicine and Cellular Longevity

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The excessive fluoride (F) exposure is associated with damage to cellular processes of different tissue types, due to changes in enzymatic metabolism and breakdown of redox balance. However, few studies evaluate doses of F compatible with human consumption. Thus, this study evaluated the effects of chronic exposure to sodium fluoride (NaF) on peripheral blood of mice from the evaluation of biochemical parameters. The animals were divided into three groups (n = 10) and received three concentrations of NaF in the drinking water for 60 days: 0 mg/L F, 10 mg/L F, and 50 mg/L F. The blood was then collected for trolox equivalent antioxidant capacity (TEAC), thiobarbituric acid reactive substances (TBARS), concentrations of nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH). The results showed that doses of 10 mg/L F and 50 mg/L F were able to increase TBARS concentration and decrease NO levels and CAT activity in the blood, but there was no statistical difference for SOD levels. The 50 mg/L F group showed an increase in TEAC levels and a decrease in the GSH content when compared to the control group. In this way, oxidative changes in blood from chronic exposure to F, especially at the highest dose, indicate that F may be a toxic agent and, therefore, the long-term exposure to excessive doses should be avoided.

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“…Природа генотоксического потенциала фторид-иона, вероятно, ассоциирована с его способностью вызывать митохондриальные повреждения и оксидативный стресс [27,[63][64][65][66]68], а также ингибировать активность ферментов антиоксидантной системы [5,67]. Существуют версии о возможном влиянии фторид-иона на активность систем репарации ДНК [56], ферментов системы биотрансформации ксенобиотиков [4] или его способности запускать эпигенетические механизмы, приводящие к генотоксическим последствиям [70]. Данные гипотезы в будущем заслуживают пристального внимания.…”

Section: Discussionunclassified

Genotoxic properties of fluorines (review)

Калюжная¹,

Prosekov²,

Volobaev³

2020

Hygiene and Sanitation

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Introduction. Consistency of fluoride excess in the human environment and professional contact with fluoride is an actual and underestimated problem. Fluoride ion is able to displace the hydroxyl group in calcium hydroxyapatites, forming stable crystals of mixed form of apatites, inducing bone pathology, fluorosis. Despite the high prevalence of fluorosis, there are only a few studies discussing the ability of fluoride ion to increase the level of genotoxic effects. At the same time, such studies are in high demand in connection with a direct correlation between genetic instability and the risk of carcinogenesis. Material and methods. A literature search was conducted according the following queries: “fluoride, fluoride ion, fluorides, DNA damage, genetic damage, genotoxicity.” The search was conducted on the databases PubMed, MEDLINE, Embase and Google Scholar for various articles (all publications until June 2018). All publications were analyzed and included in this review. Results.The present review examines the results of studies aimed at investigation of the ability of fluoride to induce DNA damage, published since the 50-s of 20th century to the present. The analyse of data about genotoxic and mutagenic properties of fluorine observed in In vitro and In vivo studies is provided. It is summarized that at concentrations of sodium fluoride in drinking water of more than 1 mM, fluoride ion has the ability to induce DNA damage and increase the frequency of clastogenic effects in humans and large monkeys. At the same time, for a significant increase in genotoxic effects in rodents, large concentrations of fluorides are required. The main hypotheses about the mechanisms of the fluoride genotoxic properties are described. Conclusion. Considering results published nowadays, it can be noted that fluoride ion obviously showes a number of genotoxic features and can have mutagenic properties in case of chronic and direct contact with cellular objects. It remains questionable issue about genotoxic risk accompanied human contact with fluoride compounds.

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Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

Cited by 31 publications

References 44 publications

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Moringa Oleifera Leaf Extract Repairs the Oxidative Misbalance following Sub-Chronic Exposure to Sodium Fluoride in Nile Tilapia Oreochromis niloticus

Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation

Genotoxic properties of fluorines (review)

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