Coagulation Testing in Intracerebral Hemorrhage Related to Non-vitamin K Antagonist Oral Anticoagulants

Purrucker, Jan; Rizos, Timolaos; Haas, Kirsten; Wolf, Marcel; Khan, Shujah; Heuschmann, Peter U.; Veltkamp, Roland; investigators, Rasunoa

doi:10.1007/s12028-017-0403-x

Cited by 13 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has the function of nutritive neurons in the neuron and can release several neurotoxins when damaged; therefore, the 2 can evaluate the degree of neurological damage to a certain extent. [24][25][26] According to Wang et al, serum S100 protein and NSE levels were positively correlated with the severity of neurological damage in patients with acute ischemic cerebral infarction. [27] Additionally, our research demonstrated that, in this group, the NIHSS score, cerebral infarction volume, NSE, and S100 levels after Tongqiao Huoxue Decoction combined with Jin three-needle treatment were lower than those before treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of Jin three needles combined with Tong Qiao and blood activation Tang on neurological function, coagulation function and serum level in stroke patients

2023

View full text Add to dashboard Cite

To investigate the efficacy and safety of Jin three needles combined with Tong Qiao Wu Blood-streaming Tang in patients with acute ischemic stroke (AIS), this retrospective study analyzed the data of patients with AIS between January 2017 and December 2022. The National Institutes of Health Stroke Scale (NIHSS) scores, blood neuron-specific enolase, S100β protein (S100β), fibrinogen (FIB), cerebral infarct volume, D-dimer (D-D), prothrombin time (PT), activated partial thromboplastin time, hypersensitive c-reactive protein (hs-CRP), serum tumor necrosis factor-α (TNF-α), and homocysteine (Hcy) were compared between the 2 groups. The treatment effect was significantly better in the observation group than in the comparison group (P < .05). The NIHSS score, neuron-specific enolase, S100β, and cerebral infarct volume were significantly lower in both groups after treatment than before treatment (P < .05). FIB and D-D levels were significantly lower and APTT and PT levels were significantly higher in both groups after treatment than before treatment (P < .05). TNF-α, hs-CRP, and Hcy were significantly lower in both groups after treatment than before treatment, and TNF-α, hs-CRP and Hcy were significantly lower in the observation group than in the comparison group (P < .05). No statistically significant difference in the incidence of adverse reactions occurred between the 2 groups (P > .05). Combining Jin three needles can improve the therapeutic effect in patients with AIS, promote the recovery of neurological function, improve coagulation function, and reduce the inflammatory response with good safety.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Jin three needles combined with Tong Qiao and blood activation Tang on neurological function, coagulation function and serum level in stroke patients

2023

View full text Add to dashboard Cite

show abstract

“…Anders als bei den Vitamin-K-Antagonisten ist bei direkten oralen Antikoagulanzien (DOAK) die antikoagulatorische Wirkung allerdings nicht anhand routinemäßig bestimmbarer Gerinnungsparameter wie der International Normalized Ratio (INR) oder der aktivierten partiellen Thromboplastinzeit (aPTT) beurteilbar [33]. Zur Bestimmung der antikoagulatorischen Wirkung der FXa-Hemmer kann die substanzspezifisch kalibrierte Anti-Xa-Aktivität gemessen werden.…”

Section: Intrazerebrale Blutungen Unter Den Faktor-xa-inhibitoren Api...unclassified

Spezifische Pharmakotherapie bei intrazerebralen Blutungen unter oraler Antikoagulation

Rangus¹,

Rennenberg²,

Nolte³

2023

Notfallmedizin up2date

View full text Add to dashboard Cite

Intrazerebrale Blutungen (ICB) gehen mit einer hohen Mortalität und Morbidität einher. Insbesondere die ICB unter oraler Antikoagulation (OAK) stellt eine therapeutische Herausforderung dar. Bei einer OAK-assoziierten ICB ist ein wesentliches Therapieziel die Wiederherstellung der Hämostase. Dieser Übersichtsartikel beschreibt die Indikationen, Anwendung und Wirksamkeit der spezifischen Gegenmittel bei ICB unter OAK anhand der aktuellen Literatur.

show abstract

“…Intrazerebrale Blutungen unter den Faktor-Xa-Inhibitoren Apixaban oder Rivaroxaban Anders als bei den Vitamin-K-Antagonisten ist bei direkten oralen Antikoagulanzien (DOAK) die antikoagulatorische Wirkung allerdings nicht anhand routinemäßig bestimmbarer Gerinnungsparameter wie der International Normalized Ratio (INR) oder der aktivierten partiellen Thromboplastinzeit (aPTT) beurteilbar [33]. Zur Bestimmung der antikoagulatorischen Wirkung der FXa-Hemmer kann die substanzspezifisch kalibrierte Anti-Xa-Aktivität gemessen werden.…”

Section: Merkeunclassified

Spezifische Pharmakotherapie bei intrazerebralen Blutungen unter oraler Antikoagulation

Rangus

Rennenberg

Nolte

2023

Gefäßmedizin Scan - Zeitschrift für Angiologie, Gefäßchirurgie,

View full text Add to dashboard Cite

Coagulation Testing in Intracerebral Hemorrhage Related to Non-vitamin K Antagonist Oral Anticoagulants

Abstract: Drug-specific tests are only infrequently used in NOAC-ICH. Normal results in non-specific coagulation do not reliably rule out peak range concentrations. Anticoagulation intensity at admission does not predict baseline hematoma volume or subsequent hematoma expansion.

Cited by 13 publications

References 16 publications

Effect of Jin three needles combined with Tong Qiao and blood activation Tang on neurological function, coagulation function and serum level in stroke patients

Effect of Jin three needles combined with Tong Qiao and blood activation Tang on neurological function, coagulation function and serum level in stroke patients

Spezifische Pharmakotherapie bei intrazerebralen Blutungen unter oraler Antikoagulation

Spezifische Pharmakotherapie bei intrazerebralen Blutungen unter oraler Antikoagulation

Contact Info

Product

Resources

About